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Dysregulated Wnt/β-catenin signaling confers resistance to cuproptosis in cancer cells
Cuproptosis is characterized by the aggregation of lipoylated enzymes of the tricarboxylic acid cycle and subsequent loss of iron-sulfur cluster...
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Elucidating CTLA-4’s role in tumor immunity: a comprehensive overview of targeted antibody therapies and clinical developments
Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) emerges as a key single-chain transmembrane glycoprotein predominantly expressed in effector T...
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Synthesis, Characterization, Phytochemistry, and Therapeutic Potential of Azadirachta indica Conjugated Silver Nanoparticles: A Comprehensive Study on Antidiabetic and Antioxidant Properties
Nanotechnology has become a major topic of study, particularly in the medical and health domains. Because nanomedicine has a higher recovery rate...
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Accuracy of prediction from multi-environment trials for new locations using pedigree information and environmental covariates: the case of sorghum (Sorghum bicolor (L.) Moench) breeding
Key messagesWe investigate a method of extracting and fitting synthetic environmental covariates and pedigree information in multilocation trial data...
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Proteome profiling, biochemical and histological analysis of diclofenac-induced liver toxicity in Yersinia enterocolitica and Lactobacillus fermentum fed rat model: a comparative analysis
Diclofenac is a hepatotoxic non-steroidal anti-inflammatory drug (NSAID) that affects liver histology and its protein expression levels. Here, we...
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LINC01133 promotes pancreatic ductal adenocarcinoma epithelial–mesenchymal transition mediated by SPP1 through binding to Arp3
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with limited treatment methods. Long non-coding RNAs (lncRNAs) have been found involved...
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Unveiling the mechanism of essential oil action against skin pathogens: from ancient wisdom to modern science
Essential oils are among the most well-known phyto-compounds, and since ancient times, they have been utilized in medicine. Over 100 essential oils...
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Influence of Suppressor of Cytokine Signaling 1 (SOCS1) Gene Variations on Polycystic Ovary Syndrome
Polycystic ovarian syndrome (PCOS) is associated with low-grade systemic inflammation and an increase in inflammation markers, which are crucial in...
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Pathogenesis of cardiovascular diseases: effects of mitochondrial CF6 on endothelial cell function
Cardiovascular disease (CVD) stands as a predominant global cause of morbidity and mortality, necessitating effective and cost-efficient therapies...
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The E2F family: a ray of dawn in cardiomyopathy
Cardiomyopathies are a group of heterogeneous diseases, characterized by abnormal structure and function of the myocardium. For many years, it has...
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Resolving chaperone-assisted protein folding on the ribosome at the peptide level
Protein folding in vivo begins during synthesis on the ribosome and is modulated by molecular chaperones that engage the nascent polypeptide. How...
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Niclosamide modulates phenotypic switch and inflammatory responses in human pulmonary arterial smooth muscle cells
Excessive proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs) represent key steps of pulmonary vascular remodeling,...
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Evaluating the Impact of an Organic Trace Mineral mix on the Redox Homeostasis, Immunity, and Performance of Sows and their Offspring
The objective of the study was to evaluate the effects of trace mineral supplementation in sows during gestation and lactation on the performance and...
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Delineation of the phenotypes and genotypes of PIK3CA-related overgrowth spectrum in East asians
PIK3CA -related overgrowth spectrum (PROS) is an umbrella term to describe a diverse range of developmental disorders. Research to date has...
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An updated and comprehensive review of traditional uses, phytochemistry, and pharmacological progress on the Hypecoum genus
The Hypecoum genus belongs to the family Papaveraceae, consists of roughly 16 accepted species, and is extensively distributed from the Mediterranean...
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Genome-wide atlas of rust resistance loci in wheat
Rust diseases, including leaf rust, stripe/yellow rust, and stem rust, significantly impact wheat ( Triticum aestivum L.) yields, causing substantial...
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Dispel some mist on circulating biopterins: measurement, physiological interval and pathophysiological implication
Background and aimsBiopterins, including tetrahydrobiopterin (BH4), dihydrobiopterin (BH2), and biopterin (B), were crucial enzyme cofactors in vivo....
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