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Pharmacogenetics in Italy: current landscape and future prospects
Pharmacogenetics investigates sequence of genes that affect drug response, enabling personalized medication. This approach reduces drug-induced...
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An investigation of the molecular characterization of the tripartite motif (TRIM) family and primary validation of TRIM31 in gastric cancer
Most TRIM family members characterized by the E3-ubiquitin ligases, participate in ubiquitination and tumorigenesis. While there is a dearth of a...
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Investigation of the Circular Transcriptome in Alzheimer’s Disease Brain
Circular RNAs (circRNAs) are a subclass of non-coding RNAs which have demonstrated potential as biomarkers for Alzheimer’s disease (AD). In this...
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Targeting protein interaction networks in mitochondrial dynamics for neurodegenerative diseases
Mitochondria, the powerhouse of eukaryotic cells, are the central organelle controlling energy metabolism and apoptosis. Based on metabolic needs,...
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Unraveling metabolic pathways and key genes in Alzheimer’s, type 2 diabetes, and estrogen dysregulation among aging women: a systems biology approach
BackgroundAlzheimer’s disease (AD) and Type 2 Diabetes Mellitus (T2DM) present significant global health challenges, particularly affecting aging...
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Characterizing the Linkage of Systemic Hypoxia and Angiogenesis in High-Grade Glioma to Define the Changes in Tumor Microenvironment for Predicting Prognosis
High-grade gliomas (HGG) comprising WHO grades 3 and 4 have a poor overall survival (OS) that has not improved in the past decade. Herein, markers...
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Association of lipid-lowering drugs with risk of sarcopenia: a drug target mendelian randomization study and meta-analysis
BackgroundLipid-lowering drugs are widely used among the elderly, with some studies suggesting links to muscle-related symptoms. However, the...
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Multiple Roles of Apolipoprotein E4 in Oxidative Lipid Metabolism and Ferroptosis During the Pathogenesis of Alzheimer’s Disease
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease worldwide and has a great socio-economic impact. Modified oxidative lipid...
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The cuproptosis-related signature predicts the prognosis and immune microenvironments of primary diffuse gliomas: a comprehensive analysis
BackgroundEvidence has revealed a connection between cuproptosis and the inhibition of tumor angiogenesis. While the efficacy of a model based on...
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Unveiling the molecular landscape of cognitive aging: insights from polygenic risk scores, DNA methylation, and gene expression
BackgroundAging represents a significant risk factor for the occurrence of cerebral small vessel disease, associated with white matter (WM) lesions,...
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The Possible Neuroprotective Effect of Caffeic Acid on Cognitive Changes and Anxiety-Like Behavior Occurring in Young Rats Fed on High-Fat Diet and Exposed to Chronic Stress: Role of β-Catenin/GSK-3B Pathway
Lifestyle influences physical and cognitive development during the period of adolescence greatly. The most important of these lifestyle factors are...
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Dispersal of Pseudomonas aeruginosa biofilm using TDS97 bacteriophage and recombinant alginate lyase enzyme
Pseudomonas aeruginosa is an opportunistic human pathogen capable of forming biofilms and contaminate medical devices and food. Bacteremia caused by...
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A novel variant in GAS2 is associated with autosomal dominant nonsyndromic hearing impairment in a Chinese family
Knockout of GAS2 (growth arrest-specific protein 2), causes disorganization and destabilization of microtubule bundles in supporting cells of the...
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SARS-CoV-2-related peptides induce endothelial-to-mesenchymal transition in endothelial capillary cells derived from different body districts: focus on membrane (M) protein
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV‐2), responsible for the COVID-19, may lead to multiple organ dysfunctions and long-term...
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The heterogeneity of erythroid cells: insight at the single-cell transcriptome level
Erythroid cells, the most prevalent cell type in blood, are one of the earliest products and permeate through the entire process of hematopoietic...
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Combined effect of naringin and adipose tissue-derived mesenchymal stem cell on cisplatin nephrotoxicity through Sirtuin1/Nrf-2/HO-1 signaling pathway: a promising nephroprotective candidate
Cisplatin nephrotoxicity is a well-known emergency clinical condition caused by oxidative stress and inflammation. Naringin (NAR) is considered an...
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Exploration of subtype-specific perturbations in breast cancer
Breast cancer remains a leading cause of mortality among women, characterized by its complex and diverse nature, comprising various molecular...
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Deciphering putative protein profile of a photomorphogenic high pigment mutant of Solanum lycopersicum (hp-1) by high-throughput LC–MS/MS analysis
The mutant hp-1 is a photomorphogenic high pigment tomato mutant. It has high commercial significance as a source of non-transgenic lycopene-rich...
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Progress in mass spectrometry approaches to profiling protein–protein interactions in the studies of the innate immune system
Understanding protein–protein interactions (PPIs) is pivotal for deciphering the intricacies of biological processes. Dysregulation of PPIs underlies...
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A molecular docking study between heavy metals and hydrophilic Hsp70 protein to explore binding pockets
Microorganisms are abundant in whole biosphere and exert influential activities on numerous biological phenomena. The source of heavy metal...
