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Potential therapeutic effects of ester derivatives of Ribavirin against SARS-CoV-2
Ribavirin ( 1 ) esters 4–36 have been synthesized and tested for their anti-inflammatory and anti-viral properties against SARS-CoV-2. The impaired...
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Effects of Commonly used Surfactants, Poloxamer 188 and Tween 80, on the Drug Transport Capacity of Intestinal Glucose Transporters
Some glycoside drugs can be transported through intestinal glucose transporters (IGTs). The surfactants used in oral drug preparations can affect the...
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Analysis of Oncology and Radiation Therapy Representation on the National Board of Medical Examiners Official Practice Material for the United States National Standardized Medical Board Examinations
Radiation therapy (RT) is a critical component of multidisciplinary cancer care, but has inconsistent curricular exposure. We characterize the...
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The effects of empagliflozin on ventricular arrhythmias in heart failure patients with an implantable cardioverter-defibrillator: a double-blind randomized controlled trial
Sodium-glucose transporter 2 (SGLT2) inhibitors such as empagliflozin are one of the main treatments for type 2 diabetes mellitus (DM2) and heart...
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Effects of active vitamin D analogs and calcimimetic agents on PTH and bone mineral biomarkers in hemodialysis patients with SHPT: a network meta-analysis
ObjectiveActive vitamin D analogs and calcimimetic agents are primary drugs for patients with secondary hyperparathyroidism. Due to the different...
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Identification of acrolein as a novel diagnostic odor biomarker for 1,2,3-trichloropropane-induced hepatotoxicity in Sprague Dawley rats
Body odor is considered a diagnostic indicator of various infectious and chronic diseases. But, few studies have examined the odor markers for...
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Design of Experiments-Driven Optimization of Spray Drying for Amorphous Clotrimazole Nanosuspension
This study employed a Quality by Design (QbD) approach to spray dry amorphousclotrimazole nanosuspension (CLT-NS) consisting of Soluplus ® and...
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Reassortment incompetent live attenuated and replicon influenza vaccines provide improved protection against influenza in piglets
Swine influenza A viruses (swIAV) cause an economically important respiratory disease in modern pig production. Continuous virus transmission and...
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Gastrointestinal parasites of Wolffsohn’s viscacha (Chinchillidae: Lagidium wolffsohni), an endemic rodent species from the wild Patagonia
Parasites are ubiquitous in wildlife populations and have a profound impact on population dynamics. Interest in parasites of wildlife has increased...
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ATP-hydrolyzing, DNA-damaging and cytotoxic activities of peptide-targeted cobalt(III) complex with diethylentriamine
Coordination complexes of cobalt represent a potential alternative to anticancer platinum-derived drugs owing to multiple activities and better...
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How Can General Managers Best Leverage Medical Affairs Now and in the Future?
General managers (GMs) play a crucial role as enterprise leaders of the country affiliate of multi-national pharmaceutical companies, balancing...
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Statistical Signal Detection Algorithm in Safety Data: A Proprietary Method Compared to Industry Standard Methods
IntroductionSeveral quantitative methods have been established, in pharmacovigilance, to detect signals of disproportionate reporting (SDRs) from...
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First Insight into the Phylogenetic Diversity of Bovicola caprae Infesting Goats of Different Agro-climatic Locations in India
Bovicola caprae is an important obligate ectoparasite of goats worldwide including India. The present study aimed at the molecular confirmation,...
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Development and validation of nomogram for predicting the risk of transferring to the ICU for children with influenza
ObjectiveDevelopment of a nomogram model for predicting the magnitude of risk of transferring hospitalized children with influenza to the ICU.
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Preparation of Microsponge Drug Delivery System (MSDDS) Followed by a Scale-Up Approach
In 1987, Won invented the solid-phase porous microsphere (MS), which stores bioactive compounds in many interconnected voids. Spherical particles...
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Orchestration of antiviral responses within the infected central nervous system
Many newly emerging and re-emerging viruses have neuroinvasive potential, underscoring viral encephalitis as a global research priority. Upon entry...
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Identification of a novel member of the genus Laulavirus (family Phenuiviridae) from the entomopathogenic ascomycete fungus Cordyceps javanica
The virus family Phenuiviridae (order Hareavirales , comprising segmented negative-sense single stranded RNA viruses) has highly diverse members that...
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Antimicrobial susceptibility profile of ceftolozane/tazobactam, ceftazidime/avibactam and cefiderocol against carbapenem-resistant Pseudomonas aeruginosa clinical isolates from Türkiye
PurposeCarbapenem resistant Pseudomonas aeruginosa (CR-PA) is escalating worldwide and leaves clinicians few therapeutic options in recent years,...
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Duo photoprotective effect via silica-coated zinc oxide nanoparticles and Vitamin C nanovesicles composites
ObjectiveZinc Oxide nanoparticles (ZnO NPs) are used widely in nowadays personal care products, especially sunscreens, as a protector against UV...
