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PET Images Enhancement Using Deep Training of Reconstructed Images with Bayesian Penalized Likelihood Algorithm
PurposeTo adopt the merits of the Bayesian Penalized Likelihood (BPL) reconstruction algorithm (incl. improved contrast recovery), a deep learning...
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High-sensitivity whole-mount in situ Hybridization of Mouse Oocytes and Embryos Visualizes the Super-resolution Structures and Distributions of mRNA Molecules
Mammalian oocytes accumulate more than ten thousand mRNAs, of which three to four thousand mRNAs are translationally repressed. The timings and sites...
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The cerebellum modulates thirst
The cerebellum, a phylogenetically ancient brain region, has long been considered strictly a motor control structure. Recent studies have implicated...
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Decoding protein–RNA interactions using CLIP-based methodologies
Protein–RNA interactions are central to all RNA processing events, with pivotal roles in the regulation of gene expression and cellular functions....
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Flexible multitask computation in recurrent networks utilizes shared dynamical motifs
Flexible computation is a hallmark of intelligent behavior. However, little is known about how neural networks contextually reconfigure for different...
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Mirror game as a tool to influence interpersonal spontaneous behavior after performance
Mirror game (MG) is an exercise in which participants imitate each other. Our study explored its spontaneous behavioral consequences after...
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Establishing African genomics and bioinformatics programs through annual regional workshops
The African BioGenome Project (AfricaBP) Open Institute for Genomics and Bioinformatics aims to overcome barriers to capacity building through its...
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Metabolic gene function discovery platform GeneMAP identifies SLC25A48 as necessary for mitochondrial choline import
Organisms maintain metabolic homeostasis through the combined functions of small-molecule transporters and enzymes. While many metabolic components...
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A vagal–brainstem interoceptive circuit for cough-like defensive behaviors in mice
Coughing is a respiratory behavior that plays a crucial role in protecting the respiratory system. Here we show that the nucleus of the solitary...
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Unsupervised representation learning on high-dimensional clinical data improves genomic discovery and prediction
Although high-dimensional clinical data (HDCD) are increasingly available in biobank-scale datasets, their use for genetic discovery remains...
