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Open AccessMicroRNA-197 controls ADAM10 expression to mediate MeCP2’s role in the differentiation of neuronal progenitors
Duplication of MECP2 (Methyl-CpG-binding protein 2) causes severe mental illness called MECP2 duplication syndrome (MDS), yet the underlying mechanism remains elusive. Here we show, in Tg(MECP2) transgenic mouse ...
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Article
Open AccessElectrical coupling regulates layer 1 interneuron microcircuit formation in the neocortex
The coexistence of electrical and chemical synapses among interneurons is essential for interneuron function in the neocortex. However, it remains largely unclear whether electrical coupling between interneuro...
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Article
Basal Forebrain Cholinergic Neurons Primarily Contribute to Inhibition of Electroencephalogram Delta Activity, Rather Than Inducing Behavioral Wakefulness in Mice
The basal forebrain (BF) cholinergic neurons have long been thought to be involved in behavioral wakefulness and cortical activation. However, owing to the heterogeneity of BF neurons and poor selectivity of t...
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Open AccessErratum to: Novel function of PIWIL1 in neuronal polarization and migration via regulation of microtubule-associated proteins
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Open AccessReciprocal regulation of autism-related genes MeCP2 and PTEN via microRNAs
MeCP2 encodes a methyl-CpG-binding protein that plays a critical role in repressing gene expression, mutations of which lead to Rett syndrome and autism. PTEN is a critical tumor suppressor gene that is frequentl...
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Generation of macaques with sperm derived from juvenile monkey testicular xenografts
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Open AccessNovel function of PIWIL1 in neuronal polarization and migration via regulation of microtubule-associated proteins
Young neurons in the develo** brain establish a polarized morphology for proper migration. The PIWI family of piRNA processing proteins are considered to be restrictively expressed in germline tissues and se...