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Whole-brain in vivo base editing reverses behavioral changes in Mef2c-mutant mice

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  1. Article

    Open Access

    MicroRNA-197 controls ADAM10 expression to mediate MeCP2’s role in the differentiation of neuronal progenitors

    Duplication of MECP2 (Methyl-CpG-binding protein 2) causes severe mental illness called MECP2 duplication syndrome (MDS), yet the underlying mechanism remains elusive. Here we show, in Tg(MECP2) transgenic mouse ...

    Yu-Meng Wang, Yu-Fang Zheng, Si-Yu Yang, Zhang-Min Yang in Cell Death & Differentiation (2019)

  2. Article

    Open Access

    Electrical coupling regulates layer 1 interneuron microcircuit formation in the neocortex

    The coexistence of electrical and chemical synapses among interneurons is essential for interneuron function in the neocortex. However, it remains largely unclear whether electrical coupling between interneuro...

    **ng-Hua Yao, Min Wang, **ang-Nan He, Fei He, Shu-Qing Zhang in Nature Communications (2016)

  3. Article

    Basal Forebrain Cholinergic Neurons Primarily Contribute to Inhibition of Electroencephalogram Delta Activity, Rather Than Inducing Behavioral Wakefulness in Mice

    The basal forebrain (BF) cholinergic neurons have long been thought to be involved in behavioral wakefulness and cortical activation. However, owing to the heterogeneity of BF neurons and poor selectivity of t...

    Li Chen, Dou Yin, Tian-**ao Wang, Wei Guo, Hui Dong, Qi Xu in Neuropsychopharmacology (2016)

  4. Article

    Open Access

    Erratum to: Novel function of PIWIL1 in neuronal polarization and migration via regulation of microtubule-associated proteins

    **-** Zhao, Mao-** Yao, Si-yuan Chang, Lan-tao Gou, Mo-fang Liu in Molecular Brain (2016)

  5. Article

    Open Access

    Reciprocal regulation of autism-related genes MeCP2 and PTEN via microRNAs

    MeCP2 encodes a methyl-CpG-binding protein that plays a critical role in repressing gene expression, mutations of which lead to Rett syndrome and autism. PTEN is a critical tumor suppressor gene that is frequentl...

    **g-Wen Lyu, Bo Yuan, Tian-Lin Cheng, Zi-Long Qiu, Wen-Hao Zhou in Scientific Reports (2016)

  6. Article

    Generation of macaques with sperm derived from juvenile monkey testicular xenografts

    Zhen Liu, Yan-Hong Nie, Chen-Chen Zhang, Yi-Jun Cai, Yan Wang, Hui-** Lu in Cell Research (2016)

  7. Article

    Open Access

    Novel function of PIWIL1 in neuronal polarization and migration via regulation of microtubule-associated proteins

    Young neurons in the develo** brain establish a polarized morphology for proper migration. The PIWI family of piRNA processing proteins are considered to be restrictively expressed in germline tissues and se...

    **-** Zhao, Mao-** Yao, Si-yuan Chang, Lan-tao Gou, Mo-fang Liu in Molecular Brain (2015)