5 Result(s)
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Article
Zhenyu Xuan
English
Science, multidisciplinary
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Article
Open AccessDNA sequences performs as natural language processing by exploiting deep learning algorithm for the identification of N4-methylcytosine
N4-methylcytosine is a biochemical alteration of DNA that affects the genetic operations without modifying the DNA nucleotides such as gene expression, genomic imprinting, chromosome stability, and the develop...
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Article
Open AccessNeuroprotection by Heat Shock Factor-1 (HSF1) and Trimerization-Deficient Mutant Identifies Novel Alterations in Gene Expression
Heat shock factor-1 (HSF1) protects neurons from death caused by the accumulation of misfolded proteins by stimulating the transcription of genes encoding heat shock proteins (HSPs). This stimulatory action de...
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Article
Open AccessThe protective role of DOT1L in UV-induced melanomagenesis
The DOT1L histone H3 lysine 79 (H3K79) methyltransferase plays an oncogenic role in MLL-rearranged leukemogenesis. Here, we demonstrate that, in contrast to MLL-rearranged leukemia, DOT1L plays a protective ro...
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Article
Open AccessThe distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition
Adenocarcinoma (ADC) and squamous cell carcinoma (SqCC) are the two predominant subtypes of non-small cell lung cancer (NSCLC) and are distinct in their histological, molecular and clinical presentation. Howev...
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Article
A microRNA component of the p53 tumour suppressor network
The tumour suppressor p53 is the most commonly mutated gene in human cancers, and probably nearly all tumours have a lesion somewhere in this pathway. The p53 network is activated in response to numerous insul...
