37 Result(s)

Article

Correction: Phosphorylation of PFKFB4 by PIM2 promotes anaerobic glycolysis and cell proliferation in endometriosis

Chao Lu, Pengyun Qiao, Ruihai Fu, Yadi Wang, Jiayi Lu, ** Ling… in Cell Death & Disease (2024)

Article

Transcriptome profiling of fast/glycolytic and slow/oxidative muscle fibers in aging and obesity

Aging and obesity pose significant threats to public health and are major contributors to muscle atrophy. The trends in muscle fiber types under these conditions and the transcriptional differences between dif...

Feng-Min Zhang, Hao-Fan Wu, Ke-Fan Wang, Ding-Ye Yu… in Cell Death & Disease (2024)

Article

Circulating tumour cells predict recurrences and survival in head and neck squamous cell carcinoma patients

Patients with head and neck squamous cell carcinoma (HNSCC) are at a high risk of develo** recurrence and secondary cancers. This study evaluates the prognostic and surveillance utilities of circulating tumo...

** Zhang, Chameera Ekanayake Weeramange… in Cellular and Molecular Life Sciences (2024)

Article

USP4 promotes the proliferation, migration, and invasion of esophageal squamous cell carcinoma by targeting TAK1

Ubiquitin-specific protease 4 (USP4) represents a potential oncogene involved in various human cancers. Nevertheless, the biological roles and precise mechanism of USP4 in esophageal squamous cell carcinoma (E...

Hongdian Zhang, Youming Han, Wanyi **ao, Yongyin Gao, Zhilin Sui… in Cell Death & Disease (2023)

Article

The VAX2-LINC01189-hnRNPF signaling axis regulates cell invasion and migration in gastric cancer

Transcription factors (TFs) and long noncoding RNAs (lncRNAs) contribute to gastric cancer (GC). However, the roles of TFs and lncRNAs in the invasion and metastasis of GC remain largely unknown. Here, we obse...

Linjie Hong, ** Yang, Luyu Zhang, Xuehua Liu, **angyang Wei… in Cell Death Discovery (2023)

Article

AZGP1 activation by lenvatinib suppresses intrahepatic cholangiocarcinoma epithelial-mesenchymal transition through the TGF-β1/Smad3 pathway

Intrahepatic cholangiocarcinoma (ICC) is a primary liver malignancy and is characterized by highly aggressive and malignant biological behavior. Currently, effective treatment strategies are limited. The effec...

Liming Deng, Wenming Bao, Baofu Zhang, Sina Zhang, Ziyan Chen… in Cell Death & Disease (2023)

Article

Hepatocyte-derived exosomal miR-146a-5p inhibits hepatic stellate cell EMT process: a crosstalk between hepatocytes and hepatic stellate cells

Recently, Salidroside (Sal) has been demonstrated to suppress hepatic stellate cell (HSC) activation, a crucial event for liver fibrosis. Moreover, Sal has been reported to decrease hepatocyte injury. A growin...

Zhichao Lang, Yifei Li, Lifan Lin, **nmiao Li, Qiqi Tao, Yuhang Hu… in Cell Death Discovery (2023)

Article

The HOXD9-mediated PAXIP1-AS1 regulates gastric cancer progression through PABPC1/PAK1 modulation

Long non-coding RNAs (lncRNAs) have been functionally characterised in various diseases. LncRNA PAX-interacting protein 1-antisense RNA 1 (PAXIP1-AS1) has reportedly been associated with cancer development. Ho...

Jiaying Li, Miaomiao Pei, Wushuang **ao, Xuehua Liu, Linjie Hong… in Cell Death & Disease (2023)

Article

Correction: CHIP induces ubiquitination and degradation of HMGB1 to regulate glycolysis in ovarian endometriosis

Yujun Sun, Qian Wang, Mengxue Wang, Fangyuan Sun… in Cellular and Molecular Life Sciences (2023)

Article

Identification of matrix-remodeling associated 5 as a possible molecular oncotarget of pancreatic cancer

Pancreatic cancer has an extremely poor prognosis. Here we examined expression, potential functions and underlying mechanisms of MXRA5 (matrix remodeling associated 5) in pancreatic cancer. Bioinformatics stud...

Shi-qing Peng, **ao-ren Zhu, Ming-zhi Zhao, Yi-fan Zhang… in Cell Death & Disease (2023)

Article

Kinesin-5 Eg5 is essential for spindle assembly, chromosome stability and organogenesis in development

Chromosome stability relies on bipolar spindle assembly and faithful chromosome segregation during cell division. Kinesin-5 Eg5 is a plus-end-directed kinesin motor protein, which is essential for spindle pole...

Wen-**n Yu, Yu-Kun Li, Meng-Fei Xu, Chen-Jie Xu, Jie Chen… in Cell Death Discovery (2022)

Article

UVA induces retinal photoreceptor cell death via receptor interacting protein 3 kinase mediated necroptosis

Ultraviolet light A (UVA) is the only UV light that reaches the retina and can cause indirect damage to DNA via absorption of photons by non-DNA chromophores. Previous studies demonstrate that UVA generates re...

Zhen Yu, Victor S. M. C. Correa, Nikolaos E. Efstathiou… in Cell Death Discovery (2022)

Article

Phosphorylation of PFKFB4 by PIM2 promotes anaerobic glycolysis and cell proliferation in endometriosis

Endometriosis (EM) is one of the vanquished wonted causes of chronic pelvic sting in women and is closely associated with infertility. The long-term, complex, systemic, and post-treatment recurrence of EM wrea...

Chao Lu, Pengyun Qiao, Ruihai Fu, Yadi Wang, Jiayi Lu, ** Ling… in Cell Death & Disease (2022)

Article

EGFR/MET promotes hepatocellular carcinoma metastasis by stabilizing tumor cells and resisting to RTKs inhibitors in circulating tumor microemboli

The receptor tyrosine kinases (RTKs) family is well-recognized as vital targets for the treatment of hepatocarcinoma cancer (HCC) clinically, whereas the survival benefit of target therapy sorafenib is not sat...

Shouyang Song, Zhen Yu, Ya**g You, Chenxi Liu, **aoyu **e… in Cell Death & Disease (2022)

Article

Ischemia-induced cleavage of OPA1 at S1 site aggravates mitochondrial fragmentation and reperfusion injury in neurons

Neuronal mitochondrial dynamics are disturbed after ischemic stroke. Optic atrophy 1 (OPA1) and its GTPase activity are involved in maintaining mitochondrial cristae and inner membrane fusion. This study aimed...

**ang Li, Haiying Li, Zhongmou Xu, Cheng Ma, Tianyi Wang… in Cell Death & Disease (2022)

Article

Receptor interacting protein 3 kinase, not 1 kinase, through MLKL-mediated necroptosis is involved in UVA-induced corneal endothelium cell death

Ultraviolet (UV) is one of the most energetic radiations in the solar spectrum that can result in various tissue injury disorders. Previous studies demonstrated that UVA, which represents 95% of incident photo...

Zhen Yu, Nikolaos E. Efstathiou, Victor S. M. C. Correa… in Cell Death Discovery (2021)

Article

Quantitative analysis of phosphoproteome in necroptosis reveals a role of TRIM28 phosphorylation in promoting necroptosis-induced cytokine production

Necroptosis is a form of regulated necrotic cell death that promotes inflammation. In cells undergoing necroptosis, activated RIPK1 kinase mediates the formation of RIPK1/RIPK3/MLKL complex to promote MLKL oli...

Rui Zu, Zhen Yu, **g Zhao, **aojuan Lu, Wei Liang, Le Sun… in Cell Death & Disease (2021)

Article

Apatinib inhibits glioma cell malignancy in patient-derived orthotopic xenograft mouse model by targeting thrombospondin 1/myosin heavy chain 9 axis

We determined the antitumor mechanism of apatinib in glioma using a patient-derived orthotopic xenograft (PDOX) glioma mouse model and glioblastoma (GBM) cell lines. The PDOX mouse model was established using ...

Hui Yao, Jiangang Liu, Chi Zhang, Yunxiang Shao, Xuetao Li… in Cell Death & Disease (2021)

Article

Genome-wide CRISPR/Cas9 screening identifies CARHSP1 responsible for radiation resistance in glioblastoma

Glioblastomas (GBM) is the most common primary malignant brain tumor, and radiotherapy plays a critical role in its therapeutic management. Unfortunately, the development of radioresistance is universal. Here,...

Guo-dong Zhu, **g Yu, Zheng-yu Sun, Yan Chen, Hong-mei Zheng… in Cell Death & Disease (2021)

Article

Mitochondrial Ca²⁺ oscillation induces mitophagy initiation through the PINK1-Parkin pathway

Dysregulation of the PINK1/Parkin-mediated mitophagy is essential to Parkinson’s disease. Although important progress has been made in previous researches, the biochemical reagents that induce global and signi...

Zhengying Yu, Haipeng Wang, Wanyi Tang, Shaoyang Wang… in Cell Death & Disease (2021)