17 Result(s)

Article

PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer

Hexokinase-II (HK2) is a key enzyme involved in glycolysis, which is required for breast cancer progression. However, the underlying post-translational mechanisms of HK2 activity are poorly understood. Here, w...

Tingting Yang, Chune Ren, Pengyun Qiao, Xue Han, Li Wang, Shijun Lv… in Oncogene (2018)

Article

Correction: PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer

A correction to this paper has been published and can be accessed via a link at the top of the paper.

Tingting Yang, Chune Ren, Pengyun Qiao, Xue Han, Li Wang, Shijun Lv… in Oncogene (2020)

Article

The reciprocal interaction between tumor cells and activated fibroblasts mediated by TNF-α/IL-33/ST2L signaling promotes gastric cancer metastasis

Gastric cancer (GC) is characterized by extensive local invasion, distant metastasis and poor prognosis. In most cases, GC progression is associated with aberrant expression of cytokines or activation of signa...

Quan Zhou, **ongyan Wu, **aofeng Wang, Zhenjia Yu, Tao Pan, Zhen Li… in Oncogene (2020)

Article

Incorporation of biologic factors for the staging of de novo stage IV breast cancer

This study aimed to investigate the prognostic value of biological factors, including histological grade, estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2)...

Zhen-Yu He, Chen-Lu Lian, Jun Wang, Jian Lei, Li Hua, Juan Zhou… in npj Breast Cancer (2020)

Article

Receptor-binding domain-specific human neutralizing monoclonal antibodies against SARS-CoV and SARS-CoV-2

The outbreaks of severe acute respiratory syndrome (SARS) and Coronavirus Disease 2019 (COVID-19) caused by SARS-CoV and SARS-CoV-2, respectively, have posed severe threats to global public health and the econ...

Fei Yu, Rong **ang, **aoqian Deng, Lili Wang… in Signal Transduction and Targeted Therapy (2020)

Article

miR-22 promotes stem cell traits via activating Wnt/β-catenin signaling in cutaneous squamous cell carcinoma

Emerging evidence suggests that the cancer stem cells (CSCs) are key culprits of cancer metastasis and drug resistance. Understanding mechanisms regulating the critical oncogenic pathways and CSCs function cou...

Shukai Yuan, Peitao Zhang, Liqi Wen, Shikai Jia, Yufan Wu, Zhenlei Zhang… in Oncogene (2021)

Article

Correction: miR-22 promotes stem cell traits via activating Wnt/β-catenin signaling in cutaneous squamous cell carcinoma

Shukai Yuan, Peitao Zhang, Liqi Wen, Shikai Jia, Yufan Wu, Zhenlei Zhang… in Oncogene (2022)

Article

Characterization of a small-molecule inhibitor targeting NEMO/IKKβ to suppress colorectal cancer growth

NEMO/IKKβ complex is a central regulator of NF-κB signaling pathway, its dissociation has been considered to be an attractive therapeutic target. Herein, using a combined strategy of molecular pharmacological ...

Zhenlong Yu, Jian Gao, **aolei Zhang… in Signal Transduction and Targeted Therapy (2022)

Article

c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses

B cells secreting IL-10 functionally are recognized as functional regulatory B (B_reg) cells; however, direct evidence concerning the phenotype, regulation, and functional and clinical relevance of IL-10-secreting...

Xu-Yan Wang, Yuan Wei, Bo Hu, Yuan Liao… in Signal Transduction and Targeted Therapy (2022)

Article

NUPR1 promotes the proliferation and metastasis of oral squamous cell carcinoma cells by activating TFE3-dependent autophagy

Oral squamous cell carcinoma (OSCC) is the most common type of oral malignancy, and metastasis accounts for the poor prognosis of OSCC. Autophagy is considered to facilitate OSCC development by mitigating vari...

Tengfei Fan, **aoning Wang, Sheng Zhang… in Signal Transduction and Targeted Therapy (2022)

Article

Correction to: NUPR1 promotes the proliferation and metastasis of oral squamous cell carcinoma cells by activating TFE3-dependent autophagy

Tengfei Fan, **aoning Wang, Sheng Zhang… in Signal Transduction and Targeted Therapy (2022)

Article

The miR-3648/FRAT1-FRAT2/c-Myc negative feedback loop modulates the metastasis and invasion of gastric cancer cells

Although the abnormal expression of miRNAs in cancer cells is a widely accepted phenomenon, the molecular mechanisms underlying miR-3648 progression and metastasis in gastric cancer (GC) remain unclear. miR-36...

Weimei Tang, Miaomiao Pei, Jiaying Li, Nanzhu Xu, Wushuang **ao, Zhen Yu… in Oncogene (2022)

Article

SARS-CoV-2 N protein enhances the anti-apoptotic activity of MCL-1 to promote viral replication

Viral infection in respiratory tract usually leads to cell death, impairing respiratory function to cause severe disease. However, the diversity of clinical manifestations of SARS-CoV-2 infection increases the...

Pan Pan, Weiwei Ge, Zhiwei Lei, Wei luo… in Signal Transduction and Targeted Therapy (2023)

Article

Correction: Characterization of a small-molecule inhibitor targeting NEMO/IKKβ to suppress colorectal cancer growth

Zhenlong Yu, Jian Gao, **aolei Zhang… in Signal Transduction and Targeted Therapy (2023)

Article

Correction: miR-22 promotes stem cell traits via activating Wnt/β-catenin signaling in cutaneous squamous cell carcinoma

Shukai Yuan, Peitao Zhang, Liqi Wen, Shikai Jia, Yufan Wu, Zhenlei Zhang… in Oncogene (2024)

Article

Fc receptor-like 5 (FCRL5)-directed CAR-T cells exhibit antitumor activity against multiple myeloma

Multiple myeloma (MM) remains a challenging hematologic malignancy despite advancements in chimeric antigen receptor T-cell (CAR-T) therapy. Current targets of CAR-T cells used in MM immunotherapy have limitat...

Zhengyu Yu, Hexian Li, Qizhong Lu… in Signal Transduction and Targeted Therapy (2024)

Article

Correction: c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses

Xu-Yan Wang, Yuan Wei, Bo Hu, Yuan Liao… in Signal Transduction and Targeted Therapy (2024)