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  1. Article

    Open Access

    NOX4 blockade suppresses titanium nanoparticle-induced bone destruction via activation of the Nrf2 signaling pathway

    Periprosthetic osteolysis (PPO) triggered by wear particles is the most severe complication of total joint replacement (TJR) surgeries, representing the major cause of implant failure, which is public health c...

    Wei Wang, **aolong Liang, **n Liu, Jiaxiang Bai, Wei Zhang in Journal of Nanobiotechnology (2022)

  2. Article

    Open Access

    GSK-3β suppression upregulates Gli1 to alleviate osteogenesis inhibition in titanium nanoparticle-induced osteolysis

    Wear particle-induced periprosthetic osteolysis (PPO) have become a major reason of joint arthroplasty failure and secondary surgery following joint arthroplasty and thus pose a severe threat to global public ...

    Qing Wang, Wei Zhang, **aole Peng, Yunxia Tao, Ye Gu in Journal of Nanobiotechnology (2022)