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Open AccessToward innovative veterinary nanoparticle vaccines
Nanoparticles are significant for veterinary vaccine development because they are safer and more effective than conventional formulations. One promising area of research involves self-assembled protein nanopar...
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Article
Blockade of de novo pyrimidine biosynthesis triggers autophagic degradation of oncoprotein FLT3-ITD in acute myeloid leukemia
The internal tandem duplication of the FMS-like tyrosine kinase 3 (FLT3-ITD) is one of the most frequent genetic alterations in acute myeloid leukemia (AML). Limited and transient clinical benefit of FLT3 kina...
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Open AccessOptimal reactive nitrogen control pathways identified for cost-effective PM2.5 mitigation in Europe
Excess reactive nitrogen (Nr), including nitrogen oxides (NOx) and ammonia (NH3), contributes strongly to fine particulate matter (PM2.5) air pollution in Europe, posing challenges to public health. Designing cos...
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Efficient phosphate recycling by adsorption on alkaline sludge biochar
Large amounts of septic tank sludges from sanitation facilities are either landfilled or illegally dumped into the natural environment, leading to environmental pollution and waste of resources. This issue cal...
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Open AccessThe truncated form of flagellin (tFlic) provides the 2dCap subunit vaccine with better immunogenicity and protective effects in mice
Porcine circovirus type 2 (PCV2) is the main causative agent of porcine circovirus-associated diseases, and it causes substantial economic losses in the swine industry each year. It is crucial to develop an ef...
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Comprehensive characterization of protein–protein interactions perturbed by disease mutations
Technological and computational advances in genomics and interactomics have made it possible to identify how disease mutations perturb protein–protein interaction (PPI) networks within human cells. Here, we sh...
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Phase-Resolved Measurement of Atmospheric-Pressure Radio-Frequency Pulsed Discharges in Ar/CH4/CO2 Mixture
In order to comprehensively investigate the discharge characteristics of an atmospheric-pressure radio-frequency (RF) pulsed discharge in Ar/CH4/CO2, a phase-resolved measurement is given in this paper. Firstly, ...
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Defending against Packet-In messages flooding attack under SDN context
Software-defined networking (SDN) is the key outcome of extensive research efforts over the past few decades toward transforming the Internet to a more programmable, configurable, and manageable infrastructure...
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Open AccessSurface displaying of swine IgG1 Fc enhances baculovirus-vectored vaccine efficacy by facilitating viral complement escape and mammalian cell transduction
Baculovirus-mediated gene transfer has been developed as a vaccine design strategy against a number of diseases without apparent viral replication. However, it has been hampered by complement-dependent inactiv...
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Estimation and inference for additive partially nonlinear models
In this paper, we extend the additive partially linear model to the additive partially nonlinear model in which the linear part of the additive partially linear model is replaced by a nonlinear function of the...
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Comparative analysis of mesenchymal stem cells from adult mouse adipose, muscle, and fetal muscle
Recently, increasing evidence supports that adult stem cells are the part of a natural system for tissue growth and repair. This study focused on the differences of mesenchymal stem cells from adult adipose (A...
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Renal tubular epithelial cell injury, apoptosis and inflammation are involved in melamine-related kidney stone formation
The objective of this study is to understand pathogenesis of melamine-related kidney stone formation. We investigated the characterization of renal tubular cell under exposure to a mixture of melamine and cyan...
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Open AccessInhibition of adipogenic differentiation by myostatin is alleviated by arginine supplementation in porcine-muscle-derived mesenchymal stem cells
Porcine mesenchymal stem cells in postnatal muscle have been demonstrated to differentiate into adipocytes. This increases adipocyte number and lipid accumulation, and is thought to be the origin of intramuscu...