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    Article

    20(S)-25-methoxyl-dammarane-3β, 12β, 20-triol negatively regulates activation of STAT3 and ERK pathways and exhibits anti-cancer effects in HepG2 cells

    The pro-inflammatory cytokine interleukin 6 (IL-6), via activating its downstream JAK/STAT3 and Ras/ERK signaling pathways, is involved in cell growth, proliferation and anti-apoptotic activities in various ma...

    Hui-Han Ai, Zi-Long Zhou, Lu-Guo Sun, Mei-Ting Yang, Wei Li, Chun-Lei Yu… in Apoptosis (2017)

  2. Article

    In vitro assessment of the glucose-lowering effects of berberrubine-9-O-β-D-glucuronide, an active metabolite of berberrubine

    Berberrubine (BRB) is the primary metabolite of berberine (BBR) that has shown a stronger glucose-lowering effect than BBR in vivo. On the other hand, BRB is quickly and extensively metabolized into berberrubine-...

    Na Yang, Run-bin Sun, **ng-long Chen, Le Zhen, Chun Ge… in Acta Pharmacologica Sinica (2017)

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