297 Result(s)
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Article
Yu-** Hung
Science, Humanities and Social Sciences, multidisciplinary
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Article
Regioselective one-pot protection of carbohydrates
The structural complexity that makes carbohydrates important in so many biological processes renders their chemical synthesis difficult. Though it is possible to synthesize pure oligosaccharides in the laborat...
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Functionalized arrays of Raman-enhancing nanoparticles for capture and culture-free analysis of bacteria in human blood
Detecting bacteria in clinical samples without using time-consuming culture processes would allow rapid diagnoses. Such a culture-free detection method requires the capture and analysis of bacteria from a body...
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Spatiotemporally controlled induction of autophagy-mediated lysosome turnover
Lysosomes are the major degradative compartments within cells, harbouring a wide variety of hydrolytic enzymes within their lumen. Release of lysosomal hydrolases from lysosomes into the cell cytoplasm results...
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miR-1 and miR-206 target different genes to have opposing roles during angiogenesis in zebrafish embryos
As miR-1 and miR-206 share identical seed sequences, they are commonly speculated to target the same gene. Here, we identify an mRNA encoding seryl-tRNA synthetase (SARS), which is targeted by miR-1, but refracto...
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IKKα restoration via EZH2 suppression induces nasopharyngeal carcinoma differentiation
Lack of cellular differentiation is a key feature of nasopharyngeal carcinoma (NPC), but it also presents as a unique opportunity for intervention by differentiation therapy. Here using RNA-seq profiling analy...
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Open Accessp-type Mesoscopic Nickel Oxide/Organometallic Perovskite Heterojunction Solar Cells
In this article, we present a new paradigm for organometallic hybrid perovskite solar cell using NiO inorganic metal oxide nanocrystalline as p-type electrode material and realized the first mesoscopic NiO/per...
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Open AccessAndrographolide induces vascular smooth muscle cell apoptosis through a SHP-1-PP2A-p38MAPK-p53 cascade
The abnormal growth of vascular smooth muscle cells (VSMCs) is considered a critical pathogenic process in inflammatory vascular diseases. We have previously demonstrated that protein phosphatase 2 A (PP2A)-me...
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PP2A and Aurora differentially modify Cdc13 to promote telomerase release from telomeres at G2/M phase
In yeast, the initiation of telomere replication at the late S phase involves in combined actions of kinases on Cdc13, the telomere binding protein. Cdc13 recruits telomerase to telomeres through its interacti...
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Open AccessCompleting bacterial genome assemblies: strategy and performance comparisons
Determining the genomic sequences of microorganisms is the basis and prerequisite for understanding their biology and functional characterization. While the advent of low-cost, extremely high-throughput second...
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Open AccessCharacterization and Modeling of Nonfilamentary Ta/TaOx/TiO2/Ti Analog Synaptic Device
A two-terminal analog synaptic device that precisely emulates biological synaptic features is expected to be a critical component for future hardware-based neuromorphic computing. Typical synaptic devices base...
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Open AccessScreening of aptamers specific to colorectal cancer cells and stem cells by utilizing On-chip Cell-SELEX
Colorectal cancer (CRC) is the most frequently diagnosed cancer around the world, causing about 700,000 deaths every year. It is clear now that a small fraction of CRC, named colorectal cancer stem cells (CSCs...
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Open AccessA New Approach to Reduce Toxicities and to Improve Bioavailabilities of Platinum-Containing Anti-Cancer Nanodrugs
Platinum (Pt) drugs are the most potent and commonly used anti-cancer chemotherapeutics. Nanoformulation of Pt drugs has the potential to improve the delivery to tumors and reduce toxic side effects. A major c...
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Open AccessAge and CHADS2 Score Predict the Effectiveness of Renin-Angiotensin System Blockers on Primary Prevention of Atrial Fibrillation
Renin-angiotensin system (RAS) blockers have potential protective effects against atrial fibrillation (AF). The purpose of this study was to determine if patient characteristics and underlying co-morbidities c...
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Open AccessPPL2ab neurons restore sexual responses in aged Drosophila males through dopamine
Male sexual desire typically declines with ageing. However, our understanding of the neurobiological basis for this phenomenon is limited by our knowledge of the brain circuitry and neuronal pathways controlli...
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Correction: Corrigendum: PP2A and Aurora differentially modify Cdc13 to promote telomerase release from telomeres at G2/M phase
Nature Communications 5, Article numbder: 5312 (2014); Published: 12 November 2014; Updated: 10 July 2015 This Article incorrectly cites ref. 51 at the end of the penultimate sentence of the first paragraph of...
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Open AccessGiant colloidal silver crystals for low-loss linear and nonlinear plasmonics
The development of ultrasmooth, macroscopic-sized silver (Ag) crystals exhibiting reduced losses is critical to fully characterize the ultimate performance of Ag as a plasmonic material, and to enable cascaded...
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Open AccessEpidural anesthesia for laparoscopic bariatric surgery: a case report
Rapid and uneventful postoperative recovery following general anesthesia in morbidly obese patients undergoing bariatric surgery may offer challenges to anesthesiologists. With improved surgical techniques and...
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Open AccessPredominant structural configuration of natural antibody repertoires enables potent antibody responses against protein antigens
Humoral immunity against diverse pathogens is rapidly elicited from natural antibody repertoires of limited complexity. But the organizing principles underlying the antibody repertoires that facilitate this im...
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Open AccessComparative Study of Outcomes among Patients with Polycystic Kidney Disease on Hemodialysis and Peritoneal Dialysis
Polycystic kidney disease (PCKD) is the most common hereditary cause of end-stage renal disease, the complications of which may prevent the choice of peritoneal dialysis (PD). The aim of this study was to expl...
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Open AccessThe variability and seasonality of the environmental reservoir of Mycobacterium bovis shed by wild European badgers
The incidence of Mycobacterium bovis, the causative agent of bovine tuberculosis, has been increasing in UK cattle herds resulting in substantial economic losses. The European badger (Meles meles) is implicated a...
