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Article
Regio-specific biotransformation of alizarin to alizarin methoxide with enhanced cytotoxicity against proliferative cells
Alizarin has been reported to have an antigenotoxic activity along with an inhibitory effect on the tumor cell growth of human colon carcinoma cells. Alizarin was biotransformed into an O-methoxide derivative usi...
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Article
Metabolic engineering of Agrobacterium sp. ATCC31749 for curdlan production from cellobiose
Curdlan is a commercial polysaccharide made by fermentation of Agrobacterium sp. Its anticipated expansion to larger volume markets demands improvement in its production efficiency. Metabolic engineering for stra...
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Article
Bioconversion of compactin into pravastatin by Streptomyces sp.
Streptomyces sp. Y-110, isolated from soil, modified compactin to pravastatin, a therapeutic agent for hypercholesterolemia. In a batch culture, the highest production of pravastatin was 340 mg l−1 from 750 mg c...
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Article
Extracellular production of a glycolipid biosurfactant, mannosylerythritol lipid, from Candida antarctica
Candida antarctica (sp. SY16) required avegetable oil as the carbon source to produce a biosurfactant, mannosylerythritol lipid (MEL-SY16). Biosurfactant production was 31 g l−1 after 7 days in a batch culture a...
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Article
Expression of sfp gene and hydrocarbon degradation by Bacillus subtilis
Bacillus subtilis C9 produces a lipopeptide-type biosurfactant, surfactin, and rapidly degrades alkanes up to a chain length of C19. The nucleotide sequence of the sfp gene cloned from B. subtilis C9 was determi...