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Article
Open AccessChildhood intra- and extra-familial maltreatment and later-life trajectories of depressive symptoms: evidence from China
Both late-life depression and childhood maltreatment have become major global public health issues, given their prevalence and social-economic and health consequences. However, previous studies have solely foc...
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Article
Open AccessAccelerating drug development for amyotrophic lateral sclerosis: construction and application of a disease course model using historical placebo group data
Amyotrophic lateral sclerosis (ALS) is an irreversible degenerative disease. Placebo-controlled randomized trials are currently the main trial design to assess the clinical efficacy of drugs for ALS treatment....
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Article
Open AccessBi-potential hPSC-derived Müllerian duct-like cells for full-thickness and functional endometrium regeneration
Stem cell-based tissue regeneration strategies are promising treatments for severe endometrial injuries. However, there are few appropriate seed cells for regenerating a full-thickness endometrium, which mainl...
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Article
Vaccaria n-Butanol Extract Lower the Production of Proinflammatory Cytokines and the Infection Risk of T. spiralis In Vivo
Trichinellosis is a severe zoonosis involving the activation of inflammatory cells, accompanied by the prominent expressions of proinflammatory cytokines in the host. Semen vaccariae, the seeds of Vaccaria segeta...