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    Article

    Rab11b promotes M1-like macrophage polarization by restraining autophagic degradation of NLRP3 in alcohol-associated liver disease

    Macrophage polarization is vital to mounting a host defense or repairing tissue in various liver diseases. Excessive activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome is related to th...

    Yu-xin Zhao, Ying-yin Sun, Liang-yun Li, **ao-feng Li… in Acta Pharmacologica Sinica (2024)

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    Article

    Hesperetin derivative 2a inhibits lipopolysaccharide-induced acute liver injury in mice via downregulation of circDcbld2

    Acute liver injury (ALI) is a complex, life-threatening inflammatory liver disease, and persistent liver damage leads to rapid decline and even failure of liver function. However, the pathogenesis of ALI is st...

    Li-jiao Sun, **n Chen, Sai Zhu, **-** Xu, **ao-feng Li… in Acta Pharmacologica Sinica (2024)