21 Result(s)

Article

Association analysis of the dopamine D3 receptor gene ser9gly and brain-derived neurotrophic factor gene val66met polymorphisms with antipsychotic-induced persistent tardive dyskinesia and clinical expression in chinese schizophrenic patients

The association between the dopamine D3 receptor (DRD3) ser9gly genetic polymorphism and tardive dyskinesia (TD), a serious adverse motor disorder after long-term antipsychotic treatment, has been studied extensi...

Ying-Jay Liou, Ding-Lieh Liao, Jen-Yeu Chen, Ying-Chieh Wang… in NeuroMolecular Medicine (2004)

Article

Presenilin-1 Regulates the Expression of p62 to Govern p62-dependent Tau Degradation

Mutations in presenilin-1 (PS1) are tightly associated with early-onset familial Alzheimer’s disease (FAD), which is characterized by extracellular amyloid plaques and the accumulation of intracellular Tau. In...

Ying-Tsen Tung, Bo-Jeng Wang, Wen-Ming Hsu, Ming-Kuan Hu… in Molecular Neurobiology (2014)

Article

UCH-L1 Inhibition Involved in CREB Dephosphorylation in Hippocampal Slices

Ubiquitin C-terminal hydrolase L1 (UCH-L1) is abundantly expressed in the brain and is critical for the normal function of synapses. cAMP response element binding protein (CREB) is a transcription factor which...

Min **e, Shao-Hui Wang, Zhi-Min Lu, Ying Pan… in Journal of Molecular Neuroscience (2014)

Article

Assessing the early changes of cerebral glucose metabolism via dynamic ¹⁸FDG-PET/CT during cardiac arrest

To study the changes of cerebral glucose metabolism (CGM) during the phase of return of spontaneous circulation (ROSC) after cardiac arrest (CA), we used 18-fluorodeoxyglucose-positron emission tomography/comp...

Ying-Qing Li, **ao-**ng Liao, Jian-Hua Lu, Rong Liu, Chun-Lin Hu… in Metabolic Brain Disease (2015)

Article

Reduced middle cingulate gyrus volume in late-onset schizophrenia in a Chinese Han population: a voxel-based structural MRI study

Hong Li, **song Tang, Li** Chen, Yanhui Liao, Bing Zhou… in Neuroscience Bulletin (2015)

Article

Valproic Acid Influences MTNR1A Intracellular Trafficking and Signaling in a β-Arrestin 2-Dependent Manner

Valproate exposure is associated with increased risks of autism spectrum disorder. To date, the mechanistic details of disturbance of melatonin receptor subtype 1 (MTNR1A) internalization upon valproate exposu...

Ling-juan Hong, Quan Jiang, Sen Long, Huan Wang, Ling-di Zhang… in Molecular Neurobiology (2016)

Article

Calpain-Dependent ErbB4 Cleavage Is Involved in Brain Ischemia-Induced Neuronal Death

Disturbance of neuregulin-1β/ErbB4 signaling is considered to be associated with brain ischemia, but the mechanisms of this disruption are largely unknown. In the present study, we provide evidence that degrad...

Ying-mei Lu, Yin-** Gao, Rong-rong Tao, Mei-hua Liao… in Molecular Neurobiology (2016)

Article

A Review of the Functional and Anatomical Default Mode Network in Schizophrenia

Schizophrenia is a severe mental disorder characterized by impaired perception, delusions, thought disorder, abnormal emotion regulation, altered motor function, and impaired drive. The default mode network (D...

Mao-Lin Hu, **ao-Fen Zong, J. John Mann, Jun-Jie Zheng… in Neuroscience Bulletin (2017)

Article

Excessive Activation of NMDA Receptors Induced Neurodevelopmental Brain Damage and Cognitive Deficits in Rats Exposed to Intrauterine Hypoxia

Intrauterine hypoxia is one of the most common stressors in fetuses, which can lead to abnormal brain development and permanent neurological deficits in adulthood. Neurological disorder excitotoxicity induced ...

Ting Li, Ziqiang Luo, Yang Liu, Mingjie Wang, **aohe Yu… in Neurochemical Research (2018)

Article

A Brain-Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease

Cavernous angioma (CA) is a vascular pathology caused by loss of function in one of the 3 CA genes (CCM1, CCM2, and CCM3) that result in rho kinase (ROCK) activation. We investigated a novel ROCK2 selective inhib...

Lisa McKerracher, Robert Shenkar, Matthew Abbinanti… in Translational Stroke Research (2020)

Article

Pathophysiology and Individualized Management of Vasovagal Syncope and Postural Tachycardia Syndrome in Children and Adolescents: An Update

Vasovagal syncope (VVS) and postural tachycardia syndrome (POTS) are the main forms of orthostatic intolerance in pediatrics and both are underlying causes of neurally-mediated syncope. In recent years, increa...

Ying Liao, Junbao Du in Neuroscience Bulletin (2020)

Article

An apoptosis inhibitor suppresses microglial and astrocytic activation after cardiac ischemia/reperfusion injury

Microglial hyperactivation and apoptosis were observed following myocardial infarction and ischemia reperfusion (I/R) injury. This study aimed to test the hypothesis that the apoptosis inhibitor, Z-VAD, attenu...

Suchan Liao, Ying Luo, Titikorn Chunchai, Kodchanan Singhanat… in Inflammation Research (2022)

Article

Astrocyte Activation, but not Microglia, Is Associated with the Experimental Mouse Model of Schizophrenia Induced by Chronic Ketamine

Ketamine is a noncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors. Many experimental studies have shown that ketamine can induce cognitive impairments and schizophrenia-like symptoms. While much...

Ying Wei, Li **ao, Weihao Fan, **g Zou, Hong Yang… in Journal of Molecular Neuroscience (2022)

Article

LncRNA Tug1 Contributes Post-stroke NLRP3 Inflammasome-Dependent Pyroptosis via miR-145a-5p/Tlr4 Axis

Pyroptosis, a type of programmed cell death illuminated by inflammasomes and active caspases, is implicated in post-stroke inflammation. Our previous study showed that lncRNA taurine upregulated gene 1 (Tug1) spo...

Meiling Yao, Ying Luo, Hongjie Li, Songjie Liao, Jian Yu in Molecular Neurobiology (2022)