131 Result(s)

Article

PEX3 promotes regenerative repair after myocardial injury in mice through facilitating plasma membrane localization of ITGB3

The peroxisome is a versatile organelle that performs diverse metabolic functions. PEX3, a critical regulator of the peroxisome, participates in various biological processes associated with the peroxisome. Whe...

Jia-Teng Sun, Zi-Mu Wang, Liu-Hua Zhou, Tong-Tong Yang, Di Zhao… in Communications Biology (2024)

Article

Genome-wide identification, expression analysis of WRKY transcription factors in Citrus ichangensis and functional validation of CiWRKY31 in response to cold stress

Ichang papeda (Citrus ichangensis), a wild perennial plant of the Rutaceae family, is a cold-hardy plant. WRKY transcription factors are crucial regulators of plant growth and development as well as abiotic stres...

**g Qu, Peng **ao, Ze-Qi Zhao, Yi-Lei Wang, Yi-Ke Zeng, ** Zeng… in BMC Plant Biology (2024)

Article

Population differentiation and dynamics of five pioneer species of Gaultheria from the secondary forests in subtropical China

The influence of native secondary succession associated with anthropogenic disturbance on the biodiversity of the forests in subtropical China remains uncertain. In particular, the evolutionary response of sma...

Yi-Rong Li, Peter W. Fritsch, Gui-Gang Zhao, **ao-Juan Cheng… in BMC Plant Biology (2024)

Article

Deficiency of P2RY11 causes narcolepsy and attenuates the recruitment of neutrophils and macrophages in the inflammatory response in zebrafish

Purinergic receptor P2Y11, a G protein-coupled receptor that is stimulated by extracellular ATP, has been demonstrated to be related to the chemotaxis of granulocytes, apoptosis of neutrophils, and secretion o...

Lin Zhao, Li-feng Wang, Yi-chen Wang, Ao Liu, Qian-wen **ao… in Cell Biology and Toxicology (2024)

Article

SEEI: spherical evolution with feedback mechanism for identifying epistatic interactions

Detecting epistatic interactions (EIs) involves the exploration of associations among single nucleotide polymorphisms (SNPs) and complex diseases, which is an important task in genome-wide association studies....

De-yu Tang, Yi-jun Mao, Jie Zhao, ** Yang, Shi-yin Li, Fu-xiang Ren… in BMC Genomics (2024)

Article

NLRP4E regulates actin cap formation through SRC and CDC42 during oocyte meiosis

Members of the nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing (NLRP) family regulate various physiological and pathological processes. However, none have been shown ...

Li-Ya Shi, Yang Wang, Yan-Jie Yang, Qian Li… in Cellular & Molecular Biology Letters (2024)

Article

Author Correction: Ketogenic diet-produced β-hydroxybutyric acid accumulates brain GABA and increases GABA/glutamate ratio to inhibit epilepsy

Ya-Nan Qiao, Lei Li, Song-Hua Hu, Yuan-**n Yang, Zhen-Zhen Ma, Lin Huang… in Cell Discovery (2024)

Article

NEAT1 inhibits the angiogenic activity of cerebral arterial endothelial cells by inducing the M1 polarization of microglia through the AMPK signaling pathway

Enhancing angiogenesis may be an effective strategy to promote functional recovery after ischemic stroke. Inflammation regulates angiogenesis. Microglia are crucial cells that initiate inflammatory responses a...

Ting Chen, **n Huang, Yi-Xuan Zhao, Zhi-wen Zhou… in Cellular & Molecular Biology Letters (2024)

Article

Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity

Current anticancer therapies cannot eliminate all cancer cells, which hijack normal arginine methylation as a means to promote their maintenance via unknown mechanisms. Here we show that targeting protein argi...

Haojie Dong, **n He, Lei Zhang, Wei Chen, Yi-Chun Lin, Song-Bai Liu… in Nature Cancer (2024)

Article

LncRNA SNHG26 promotes gastric cancer progression and metastasis by inducing c-Myc protein translation and an energy metabolism positive feedback loop

Metastasis is a bottleneck in cancer treatment. Studies have shown the pivotal roles of long noncoding RNAs (lncRNAs) in regulating cancer metastasis; however, our understanding of lncRNAs in gastric cancer (G...

Zhen-Hua Wu, Yi-Xuan Wang, Jun-Jiao Song, Li-Qin Zhao, Yu-Jia Zhai… in Cell Death & Disease (2024)

Article

Lactobacillus rhamnosus GG ameliorates hyperuricemia in a novel model

Hyperuricemia (HUA) is a metabolic syndrome caused by abnormal purine metabolism. Although recent studies have noted a relationship between the gut microbiota and gout, whether the microbiota could ameliorate ...

Yang Fu, Yong-Song Chen, Dai-Yang **a, **ao-Dan Luo… in npj Biofilms and Microbiomes (2024)

Article

Correction: Multiregion WES of metastatic pancreatic neuroendocrine tumors revealed heterogeneity in genomic alterations, immune microenvironment and evolutionary patterns

Yu Jiang, Yi-han Dong, Shi-wei Zhao, Dong-yu Liu… in Cell Communication and Signaling (2024)

Article

Hypoxia and low-glucose environments co-induced HGDILnc1 promote glycolysis and angiogenesis

Small bowel vascular malformation disease (SBVM) commonly causes obscure gastrointestinal bleeding (OGIB). However, the pathogenetic mechanism and the role of lncRNAs in SBVM remain largely unknown. Here, we f...

Qing-Wei Zhang, **ao-Lu Lin, Zi-Hao Dai, Ran Zhao, Yi-Chao Hou… in Cell Death Discovery (2024)

Article

Multiregion WES of metastatic pancreatic neuroendocrine tumors revealed heterogeneity in genomic alterations, immune microenvironment and evolutionary patterns

Pancreatic neuroendocrine tumors (PanNETs), though uncommon, have a high likelihood of spreading to other body parts. Previously, the genetic diversity and evolutionary patterns in metastatic PanNETs were not ...

Yu Jiang, Yi-han Dong, Shi-wei Zhao, Dong-yu Liu… in Cell Communication and Signaling (2024)

Article

Mechanisms of intermittent theta-burst stimulation attenuating nerve injury after ischemic reperfusion in rats through endoplasmic reticulum stress and ferroptosis

Repetitive transcranial magnetic stimulation (rTMS) exerts neuroprotective effects early in cerebral ischemia/reperfusion (I/R) injury. Intermittent theta-brust stimulation (iTBS), a more time-efficient modali...

**n-Ya Shen, **ng-Yu Zhang, **-** Han, Yi-Ning Zhao… in Molecular Biology Reports (2024)

Article

Ketogenic diet-produced β-hydroxybutyric acid accumulates brain GABA and increases GABA/glutamate ratio to inhibit epilepsy

Ketogenic diet (KD) alleviates refractory epilepsy and reduces seizures in children. However, the metabolic/cell biologic mechanisms by which the KD exerts its antiepileptic efficacy remain elusive. Herein, we...

Ya-Nan Qiao, Lei Li, Song-Hua Hu, Yuan-**n Yang, Zhen-Zhen Ma, Lin Huang… in Cell Discovery (2024)

Article

Joint association of physical activity and diet quality with dyslipidemia: a cross-sectional study in Western China

This study aims to investigate the prevalence of dyslipidemia and assess the joint association of physical activity (PA) and diet quality on dyslipidemia risk in urban areas of **njiang.

Munire Mutalifu, Qian Zhao, Ying Wang, **eyire Hamulati… in Lipids in Health and Disease (2024)

Article

LDLR is an entry receptor for Crimean-Congo hemorrhagic fever virus

Crimean-Congo hemorrhagic fever virus (CCHFV) is the most widespread tick-born zoonotic bunyavirus that causes severe hemorrhagic fever and death in humans. CCHFV enters the cell via clathrin-mediated endocyto...

Zhi-Sheng Xu, Wen-Tian Du, Su-Yun Wang, Mo-Yu Wang, Yi-Ning Yang… in Cell Research (2024)

Article

Tryptophanylation of insulin receptor by WARS attenuates insulin signaling

Increased circulating amino acid levels have been linked to insulin resistance and development of type 2 diabetes (T2D), but the underlying mechanism remains largely unknown. Herein, we show that tryptophan mo...

Wen-**ng Sun, Kai-Hui Zhang, Qian Zhou, Song-Hua Hu… in Cellular and Molecular Life Sciences (2024)

Article

Bisphenol a downregulates GLUT4 expression by activating aryl hydrocarbon receptor to exacerbate polycystic ovary syndrome

Bisphenol A (BPA) levels are high in women with polycystic ovary syndrome (PCOS). The mechanism by which BPA induces abnormal glucose metabolism in PCOS patients is largely unknown.

**g Shi, Kai-Lun Hu, **ao-Xue Li, Yi-Meng Ge… in Cell Communication and Signaling (2024)