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  1. No Access

    Article

    Introductory statement

    David W. McCandless in Metabolic Brain Disease (1986)

  2. No Access

    Article

    Ammonia toxicity: Comparative protective effect of various arginine and ornithine derivatives, aspartate, benzoate, and carbamyl glutamate

    Ornithine and arginine compounds were highly effective in preventing an increase in blood ammonia and in preventing or minimizing encephalopathy after acute subcoma, comainducing, or lethal doses of NH ...

    Leslie Zieve, Carolyn Lyftogt, Donna Raphael in Metabolic Brain Disease (1986)

  3. No Access

    Article

    Brain monoamines after portacaval anastomosis

    Norepinephrine, dopamine, and serotonin, as well as the serotonin metabolite, 5-hydroxy-indoleacetic acid, were measured in whole-brain extracts from rats with a portacaval shunt or sham operation. Norepinephr...

    Anke M. Mans, Richard A. Hawkins in Metabolic Brain Disease (1986)

  4. No Access

    Article

    β-Hydroxybutyrate reverses insulin-induced hypoglycemic coma in suckling-weanling mice despite low blood and brain glucose levels

    In normal suckling-weanling mice,dl-β-hydroxybutyrate (30 mmol/kg ip) stimulated insulin secretion and reduced plasma glucose levels. In the brains of these animals, glucose levels were tripled due to a reduced r...

    Jean Holowach Thurston, Richard E. Hauhart, James A. Schiro in Metabolic Brain Disease (1986)

  5. No Access

    Article

    Metabolism and nervous system disease: A challenge for our times. Part I

    Eugene Roberts in Metabolic Brain Disease (1986)

  6. No Access

    Article

    Glycerol as an indicator of lipid degradation in bicuculline-induced seizures and experimental cerebral ischemia

    Glycerol, the end product of phospholipid degradation, was measured in cat brains under pathophysiological conditions known to cause activation of lipolysis, namely, bicucullineinduced seizures, permanent foca...

    W. Paschen, W. van den Kerckhoff, K. -A. Hossmann in Metabolic Brain Disease (1986)

  7. No Access

    Article

    Regional glucose andβ-Hydroxybutyrate use by develo** rat brain

    Rates of glucose andd-β-hydroxybutyrate use were determined in five brain regions of 20-day-old rats. The regions studied were cerebral cortex, thalamus, striatum, cerebellum, and brain stem. The tracers for dete...

    Alexander L. Miller in Metabolic Brain Disease (1986)

  8. No Access

    Article

    Phosphofructokinase activity in fibroblasts from patients with Alzheimer's disease and age- and sex-matched controls

    The activity of the enzyme phosphofructokinase (PFK) was comparable in cultured skin fibroblasts from eight patients with Alzheimer's disease and eight age- and sex-matched controls. Mean activities were simil...

    Neil R. Sims, John P. Blass in Metabolic Brain Disease (1986)

  9. No Access

    Article

    Effects of acute hyperosmolar NaCl or urea on brain H2O, Na+, K+, carbohydrate, and amino acid metabolism in weanling mice: NaCl induces insulin secretion and hypoglycemia

    This study compares early and late effects of the injection of hyperosmolar NaCl and urea of equal osmolarity on selected aspects of brain water, electrolyte, carbohydrate, amino acid, urea, and energy metabol...

    Jean Holowach Thurston, Richard E. Hauhart, John A. Dirgo… in Metabolic Brain Disease (1986)

  10. No Access

    Article

    Dietary supplementation of undernourished rats with soy or safflower oil: Effects on myelin polyunsaturated fatty acids

    Undernourished suckling rats were administered, by gastric intubation, either soy oil (which is rich in both linoleic and linolenic acids) or safflower oil (which is rich in linoleic acid but deficient in lino...

    P. Divakaran, Thomas Pavlina, Robert C. Johnson, Richard Cotter… in Metabolic Brain Disease (1986)

  11. No Access

    Article

    Regional blood-brain barrier transport of glucose after portacaval anastomosis

    The regional influx of glucose across the blood-brain barrier was measured in rats 5 to 6 weeks after a portacaval anastomosis or sham operation. D-[14C]Glucose was infused intravenously for 15sec while arterial ...

    Anke M. Mans, Donald W. Davis, Richard A. Hawkins in Metabolic Brain Disease (1986)

  12. No Access

    Article

    Cerebral metabolic effects of organophosphorus anticholinesterase compounds

    Rats treated intravenously with an organophosphoras anticholinesterase compound, paraoxon or soman, were sacrificed 2 to 131 min later, using 0.7sec of focused microwave irradiation (25 kW at 915 MHz). Brain r...

    Alexander L. Miller, Miguel A. Medina in Metabolic Brain Disease (1986)

  13. No Access

    Article

    Metabolism and nervous system disease: A challenge for our times. Part II

    Eugene Roberts in Metabolic Brain Disease (1986)

  14. No Access

    Article

    Late-onset Krabbe disease initially diagnosed as cerebroside sulfatase activator deficiency

    Clinical and biochemical findings in a male subject with progressive encephalopathy and peripheral neuropathy are presented. Early development was normal. At age 3.5 years, he had seizures associated with feve...

    Arvan L. Fluharty, Lee Neidengard, David Holtzman, Hayato Kihara in Metabolic Brain Disease (1986)

  15. No Access

    Article

    Cerebral thiamine-dependent enzyme changes in experimental Wernicke's encephalopathy

    Roger F. Butterworth in Metabolic Brain Disease (1986)

  16. No Access

    Article

    Regional metabolite profiles in early stages of global ischemia in the gerbil

    The present experiments were designed to determine the short-term regional changes in the cyclic nucleotides, certain glucose metabolites, high-energy phosphates, γ-aminobutyric acid (GABA), glutamate, and glu...

    B. B. Mrsulja, Y. Ueki, W. D. Lust in Metabolic Brain Disease (1986)

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    Article

    Book review

    R. W. Albers in Metabolic Brain Disease (1986)

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    Article

    Restraint stress during late pregnancy in rats elicits early hypermyelination in the offspring

    Female rats were subjected to a regular, daily schedule of 2 hr of restraint stress during the final 6 days of pregnancy. During the first 2 postnatal weeks, adrenal weights were greater than normal in the off...

    Richard C. Wiggins, Zehava Gottesfeld in Metabolic Brain Disease (1986)

  19. No Access

    Article

    Peroxidative aggregation of myelin membrane proteins

    The exposure of CNS myelin to reactive oxygen species (ROS) generated by a Cu2+−H2O2 system results in the aggregation of membrane proteins. Integral and peripheral membrane proteins are equally vulnerable and th...

    G. Konat, G. Gantt, A. Gorman, R. C. Wiggins in Metabolic Brain Disease (1986)

  20. No Access

    Article

    Cerebral aminoacids in portal-systemic encephalopathy: Lack of evidence for altered γ-aminobutyric acid (GABA) function

    Construction of an end-to-side portocaval anastomosis in the rat resulted, 4 weeks later, in sustained hyperammonemia and two- to threefold increases in brain ammonia. Measurement of cerebral amino acids using...

    Roger F. Butterworth, Jean-François Giguère in Metabolic Brain Disease (1986)

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