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Biochemistry, general
Neurochemistry
Neurosciences
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The opiate receptors
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The effect of methionine on the uptake, distribution, and binding of the convulsant methionine sulfoximine in the rat
The effect of methionine on the uptake, distribution, and binding of the convulsant methionine sulfoximine (MSO) in 7 rat brain regions, the spinal cord, the liver, and the kidney was investigated. The adminis...
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Resolution and reconstitution of glutamate decarboxylase from cerebellum
Brain glutamate decraboxylase (EC 4.1.1.15) catalyzes the biosynthesis of the postulated neurotransmitterγ-aminobutyric acid according to the following chemical equation:L-glutamate →γ-aminobutyric acid+CO2. Hydr...
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Glutamic acid: A strong candidate as the neurotransmitter of the cerebellar granule cell
Free amino acids and cholinergic enzymes were investigated in the cerebellum of reeler and weaver mice in an attempt to identify the neurotransmitter characteristic of the granule cell population and to clarif...
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The breakdown of myelin-bound proteins by intra- and extracellular proteases
Changes in protein components of purified myelin were measured following incubation in vitro with purified intra- and extracellular enzymes. Incubation with calf brain cathepsin D did not result in a significa...
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Purpose and scope
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Transport of 3-methoxy-4-hydroxymandelic acid by isolated rat choroid plexus
3-Methoxy-4-hydroxymandelic acid (VMA) is transported into the isolated choroid plexus against a concentration gradient by a saturable, energy-dependent system. The apparentK m for transport is 35 nM and theV max
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The action of fenfluramine andp-chloramphetamine on serotonergic mechanisms: A comparative study in rat brain nuclei
A single injection of fenfluramine orp-chloroamphetamine (PCA) (100 μmol/kg intraperitoneally) decreases the serotonin (5HT) content and the tryptophan hydroxylase activity in various areas of the rat brain. Othe...
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The turnover of thiamine and its phosphate esters in rat organs
Thiamine-deficient rats were injected with [35S]thiamine and the turnover of the injected radioactive thiamine and its phosphate esters was measured in brain, heart, and liver after returning the rats to a normal...
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Comparative studies on synaptosomes: Applicability of the rapid method for preparing synaptosomes to elasmobranch brain
A flotation technique for the rapid preparation of synaptosomes, originally developed for invertebrate nervous tissue, has now been successfully applied to that of an elasmobranch fish (Mustelis canis, dogfish). ...
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NAD+-dependent formation ofγ-aminobutyrate (GABA) from glutamate
Mitochondria and nuclei of various tissues, including brain and liver, are capable of producingγ-aminobutyrate (GABA) fromL-glutamate, but poorly, if at all, fromD-glutamate. The amino nitrogen of glutamate is fo...
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Effects of selective doses of x-irradiation on the levels of several amino acids in the cerebellum of the rat
The cerebella of rats were exposed to selective doses of low levels of x-irradiation beginning on day 4, 8, or 12 following birth. The doses of x-irradiation given on days 12, 13, and 15 (12–15X group) resulte...
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Stimulation of thiamine triphosphate metabolism in nerve by cyclic guanosine 3′,5′-monophosphate
This paper reports that addition of cGMP results in an increase of the amount of32Pi incorporated into thiamine triphosphate in nerve roots and sympathetic trunks. The effect is present both at rest and during el...
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Ganglioside sialidase activity in bovine neuronal perikarya
Neuronal perikarya were isolated, using bulk preparative procedures, from bovine brains. Synaptosomes, neuronal perikarya, and brain homogenates had similar ganglioside patterns, with the synaptosomes containi...
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Release of phosphodiesterase activator from particulate fractions of cerebellum and striatum by putative neurotransmitters
The endogenous phosphodiesterase activator (PDEA) described by Cheung (1,2) is, in part, stored as a membrane-bound protein (12,13). PDEA can be released from the membranes by a cAMP-dependent phosphorylation ...
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Changes in some properties of glutamate decarboxylase activity during the maturation of the brain
The sensitivity of cerebral glutamate decarboxylase (GAD) activity to hypotonic homogenization medium, centrifugation, Triton-X-100, and preincubation at 37°C was studied in the develo** mouse. In newborn an...
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Some properties of choline acetyltransferase isolated from the electric organ ofTorpedo marmorata: Specificity for choline analogues and inhibition by certain amines and amino acids
(1) Choline acetyltransferase ofTorpedo marmorata electric organ was studied by using soluble tissue extracts partially purified by (NH4)2SO4 fractionation. (2) Linear enzymatic rates were observed at 30°C, in th...
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Uptake of neurotransmitters and precursors by clonal lines of astrocytoma and neuroblastoma: III. Transport of choline
Clonal lines of glial, neuronal, and nonneural origin accumulate choline via a high-affinity carrier-mediated transport system withK m in the range of 10–14 μM. These cell line...
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Sialidase activity in mouse neuroblastoma cell lines
Sialidase activity was determined for three different neuroblastoma clonal lines derived from the A/J strain mouse C1300 neuroblastoma line. For each cell line, the endogenous and exogenous activities were les...
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Nomenclature proposal for proteins of the nervous system
We hope that this journal can be of service to the scientific community in many ways. One of our aims is to accomplish, this in as flexible a way as possible. A comments section may be one form of increasing f...
