93,076 Result(s)
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Medicine & Public Health
Neurosciences
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Specific association between retinal neural layer thinning and neurological soft signs in schizophrenia
There is growing evidence of disproportionate retinal thinning in schizophrenia, but doubts are still raised regarding its significance in the context of the neurobiology of the disease. Therefore, we examined...
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Cognitive horizons in chronic pain: unraveling neuroscientific insights and innovative interventions for fibromyalgia
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Negative symptoms and neurocognition in drug-naïve schizophrenia: moderating role of plasma neutrophil gelatinase-associated lipocalin (NGAL) and interferon-gamma (INF-γ)
Previous studies reported that peripheral inflammation was associated with cognitive performance and brain structure in schizophrenia. However, the moderating effect of inflammation has not been extensively st...
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GWAS of biological aging to find longevity genes in schizophrenia
Schizophrenia (SCZ) is a severe psychotic disorder associated with premature mortality and aging. Moreover, the symptoms and progression of psychiatric disorders in general are associated with decreased lifesp...
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Open AccessThe association of SOD and HsCRP with the efficacy of sulforaphane in schizophrenia patients with residual negative symptoms
Emerging evidence indicates a connection between oxidative stress, immune-inflammatory processes, and the negative symptoms of schizophrenia. In addition to possessing potent antioxidant and anti-inflammatory ...
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Genetic network structure of 13 psychiatric disorders in the general population
Psychiatric disorders frequently co-occur and share common symptoms and genetic backgrounds. Previous research has used genome-wide association studies to identify the interrelationships among psychiatric diso...
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Levels of brain-derived neurotrophic factor (BDNF) among patients with COVID-19: a systematic review and meta-analysis
Many individuals have been suffering from consistent neurological and neuropsychiatric manifestations even after the remission of coronavirus disease (COVID-19). Brain-derived neurotrophic factor (BDNF) is a p...
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Psychiatric features in NMDAR and LGI1 antibody–associated autoimmune encephalitis
Patients with autoimmune encephalitis (AE) often developed psychiatric features during the disease course. Many studies focused on the psychiatric characteristic in anti-NMDAR encephalitis (NMDAR-E), but anti-...
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Open AccessThe myth of brain damage: no change of neurofilament light chain during transient cognitive side-effects of ECT
Electroconvulsive therapy (ECT) is an effective, safe, and mostly well-tolerated treatment for patients with severe or difficult to treat depression or psychotic disorders. However, a relevant number of patien...
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Open AccessSoluble terminal complement complex blood levels are elevated in schizophrenia
The role of the complement system in schizophrenia (Sz) is inconclusive due to heterogeneity of the disease and study designs. Here, we assessed the levels of complement activation products and functionality o...
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Role of HOMA-IR and IL-6 as screening markers for the metabolic syndrome in patients with chronic schizophrenia: a psychiatric hospital-based cross-sectional study
This study starts from the metabolic related indexes and cellular inflammatory factors in patients with chronic schizophrenia to find out that it can be used as an effective screening index of metabolic syndro...
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Open AccessGender differences in clinical and biochemical parameters among patients hospitalized for schizophrenia: towards precision medicine
The scientific literature shows some gender differences in the clinical course of schizophrenia. The aim of this study is to identify gender differences in clinical and biochemical parameters in subjects affec...
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Retinal layers and symptoms and inflammation in schizophrenia
Schizophrenia is a neurodevelopmental disorder that affects brain structure and function. The retina, as well as the brain, consists of neuronal and glial cells packed in layers. Cortical volume and brain thic...
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Effects of antipsychotic drugs on energy metabolism
Schizophrenia (SCZ) is a complex neuropsychiatric disorder associated with altered bioenergetic pathways and mitochondrial dysfunction. Antipsychotic medications, both first and second-generation, are commonly...
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Open AccessMicrobiome composition and central serotonergic activity in patients with depression and type 1 diabetes
The role of gut–brain axis functioning gains growing attention in research on the pathophysiology of major depressive disorders. Here, especially consequences of altered microbiota composition on tryptophan me...
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Positive association between increased homocysteine and deficit syndrome in Chinese patients with chronic schizophrenia: a large-scale cross-sectional study
Emerging studies indicate that oxidative stress may contribute to deficit syndrome (DS) in patients with schizophrenia. Homocysteine (Hcy) is a well-known marker and mediator of oxidative stress that exhibits ...
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Plasma Apo-E mediated corticospinal tract abnormalities and suicidality in patients with major depressive disorder
This study aims to explore the link between Apo-E, brain white matter, and suicide in patients with major depressive disorder (MDD) to investigate the potential neuroimmune mechanisms of Apo-E that may lead to...
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Neural mechanisms underlying attentional bias modification in fibromyalgia patients: a double-blind ERP study
There is a growing interest in the potential benefits of attentional bias modification (ABM) training in chronic pain patients. However, studies examining the effectiveness of ABM programs in fibromyalgia pati...
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Open AccessPolygenic risk for schizophrenia and bipolar disorder in relation to cardiovascular biomarkers
Individuals with schizophrenia and bipolar disorder are at an increased risk of cardiovascular disease (CVD), and a range of biomarkers related to CVD risk have been found to be abnormal in these patients. Com...
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Open AccessDeconstructing depression by machine learning: the POKAL-PSY study
Unipolar depression is a prevalent and disabling condition, often left untreated. In the outpatient setting, general practitioners fail to recognize depression in about 50% of cases mainly due to somatic comor...
