8 Result(s)
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Article
Open AccessHepatic Sirt6 activation abrogates acute liver failure
Acute liver failure (ALF) is a deadly illness due to insufficient detoxification in liver induced by drugs, toxins, and other etiologies, and the effective treatment for ALF is very limited. Among the drug-ind...
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Article
Machine learning-based marker length estimation for garment mass customization
The quick development of mass customization in the apparel industry leads to an exponential increase of garment size combinations for markers, which induces a heavy and complex workload of marker making. In th...
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Article
Optimization of garment sizing and cutting order planning in the context of mass customization
In this paper, we present a mass customization (MC)-oriented garment production planning system using mathematical optimization methods to generate the most efficient size chart and cutting order plan. It is c...
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Article
Open AccessIMB-T130 targets 3-dehydroquinate synthase and inhibits Mycobacterium tuberculosis
The anti-tuberculosis (TB) agent IMB-T130 was speculated to be a multi-target compound. In this research, we found that IMB-T130 inhibits the catalytic activity of Mycobacterium tuberculosis 3-dehydroquinate synt...
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Article
Open AccessTannic acid as a plant-derived polyphenol exerts vasoprotection via enhancing KLF2 expression in endothelial cells
The transcription factor Kruppel-like factor 2 (KLF2) is a critical anti-inflammatory and anti-atherogenic molecule in vascular endothelium. Enhancing KLF2 expression and activity improves endothelial function...
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Article
Open AccessRGD-modified oncolytic adenovirus-harboring shPKM2 exhibits a potent cytotoxic effect in pancreatic cancer via autophagy inhibition and apoptosis promotion
The M2 isoform of pyruvate kinase (PKM2) is a key driver of glycolysis in cancer cells and has critical ‘non-metabolic’ functions in some cancers; however, the role of PKM2 in pancreatic cancer remains unclear...
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Article
Correction: Corrigendum: Identification of a novel selective agonist of PPARγ with no promotion of adipogenesis and less inhibition of osteoblastogenesis
Nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) plays an important role in the regulation of glucose homeostasis and lipid metabolism. However, current PPARγ-targeting drugs such as thiaz...
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Article
Open AccessIdentification of a novel selective agonist of PPARγ with no promotion of adipogenesis and less inhibition of osteoblastogenesis
Nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) plays an important role in the regulation of glucose homeostasis and lipid metabolism. However, current PPARγ-targeting drugs such as thiaz...
