63 Result(s)
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Article
Yang XU
Biochemistry, general
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Article
Endothelial Cells Promote Pseudo-islet Function Through BTC-EGFR-JAK/STAT Signaling Pathways
Interactions between cells are of fundamental importance in affecting cell function. In vivo, endothelial cells and islet cells are close to each other, which makes endothelial cells essential for islet cell d...
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Enhancing intracellular mRNA precise imaging-guided photothermal therapy with a nucleic acid-based polydopamine nanoprobe
Despite significant advancements in cancer research, real-time monitoring and effective treatment of cancer through non-invasive techniques remain a challenge. Herein, a novel polydopamine (PDA) nucleic acid n...
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Article
Correction to: Safety assessment, whole genome sequence, and metabolome analysis of Streptococcus thermophilus CICC 20372 for bone cement fermentation
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Preparation of glycoside precursors in flow from food flavours containing a phenolic hydroxyl group
Flavour precursors are finding increased utility within the tobacco industry to offset the diminishing aroma of cigarettes with the development of low tar cigarettes. Ethyl vanillin (EV) glucoside serves as an...
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Article
The structure and bioactivities of Stemona alkaloids and alkaloids with [1,2-α] azepine nucleus (2009–2021)
Stemona alkaloids with a unique skeleton of pyrrolo[1,2-a]azepine, pyrido[1,2-a]azepine, pyrido[1,2-a]azonine or indolizidine core are obtained only from the Stemonaceae family. And some plants from this family h...
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Safety assessment, whole genome sequence, and metabolome analysis of Streptococcus thermophilus CICC 20372 for bone cement fermentation
Bone is a kind of meat processing by-product with high nutritional value but low in calorie, which is a typical food in China and parts of East Asian countries. Microbial fermentation by lactic acid bacteria s...
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Polymorphic USP8 allele promotes Parkinson’s disease by inducing the accumulation of α-synuclein through deubiquitination
Parkinson’s disease (PD) is one of the most common neuro-degenerative diseases characterized by α-synuclein accumulation and degeneration of dopaminergic neurons. Employing genome-wide sequencing, we identifie...
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PDZK1 improves ventricular remodeling in hypertensive rats by regulating the stability of the Mas receptor
Ventricular remodeling is one of the main causes of mortality from heart failure due to hypertension. Exploring its mechanism and finding therapeutic targets have become urgent scientific problems to be solved...
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Untargeted metabolomics analysis of plasma metabolic characteristics in patients with acne and insulin resistance
Acne vulgaris is a chronic inflammatory disease with high incidence, diverse clinical manifestations, poor clinical efficacy, and easy recurrence. Recent studies have found that the occurrence of acne is relat...
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Syringaresinol protects against diabetic nephropathy by inhibiting pyroptosis via NRF2-mediated antioxidant pathway
Diabetic nephropathy (DN) is one of the serious complications of diabetes that has limited treatment options. As a lytic inflammatory cell death, pyroptosis plays an important role in the pathogenesis of DN. S...
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Open AccessIKK1 aggravates ischemia–reperfusion kidney injury by promoting the differentiation of effector T cells
Ischemia–reperfusion injury (IRI) is one of the major causes of acute kidney injury (AKI), and experimental work has revealed detailed insight into the inflammatory response in the kidney. T cells and NFκB pat...
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A novel matrine derivative, WM130, inhibits activation and movement of human hepatic stellate LX-2 cells by targeting cofilin 1
Matrine, one of the active ingredients of Sophora flavescens Ait., has a protective effect in animal models on acute liver injury and liver fibrosis. However, since the protective effects are short-lived, a struc...
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Open AccessLoss of RBMS1 promotes anti-tumor immunity through enabling PD-L1 checkpoint blockade in triple-negative breast cancer
Immunotherapy has been widely utilized in multiple tumors, however, its efficacy in the treatment of triple-negative breast cancers (TNBC) is still being challenged. Meanwhile, functions and mechanisms of RNA ...
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CD63 acts as a functional marker in maintaining hematopoietic stem cell quiescence through supporting TGFβ signaling in mice
Hematopoietic stem cell (HSC) fate is tightly controlled by various regulators, whereas the underlying mechanism has not been fully uncovered due to the high heterogeneity of these populations. In this study, ...
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Comprehensive effects of salt stress and peanut cultivars on the rhizosphere bacterial community diversity of peanut
Plant rhizosphere bacterial communities are central to plant growth and stress tolerance, which differ across cultivars and external environments. The goal of this study was to assess the comprehensive effects...
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Manipulation of Plasmon Dephasing Time in Nanostructure Arrays Via the Far-Field Coupling
On-demand manipulation of the plasmon dephasing time plays critical roles in many important applications of localized surface plasmon resonance. Here, we systemically investigate the influence of the far-field...
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Article
Genetic control of root plasticity in response to salt stress in maize
GWAS identified 559 significant SNPs associated with the remodelling of the root architecture in response to salt, and 168 candidate genes were prioritized by integrating RNA-seq, DEG and WGCNA data.
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Open AccessThe role of S-nitrosylation of PFKM in regulation of glycolysis in ovarian cancer cells
One of the malignant transformation hallmarks is metabolism reprogramming, which plays a critical role in the biosynthetic needs of unchecked proliferation, abrogating cell death programs, and immunologic esca...
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Open AccessMiR-127-3p targeting CISD1 regulates autophagy in hypoxic–ischemic cortex
Neonatal hypoxic–ischemic (HI) injury derived from asphyxia during perinatal period, is a serious complication of neonatal asphyxia and the main cause of neonatal acute death and chronic neurological injury. A...
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Open AccessThe heterocyclic compound Tempol inhibits the growth of cancer cells by interfering with glutamine metabolism
Tempol (4-hydroxy-2,2,6,6-Tetramethylpiperidine-1-oxyl, TPL), a nitroxide compound, inhibits proliferation and increases the vulnerability of cancer cells to apoptosis induced by cytotoxic agents. However, the...
