81 Result(s)

Article

Linear ubiquitination regulates the KSHV replication and transcription activator protein to control infection

Like many other viruses, KSHV has two life cycle modes: the latent phase and the lytic phase. The RTA protein from KSHV is essential for lytic reactivation, but how this protein’s activity is regulated is not ...

Yi Luan, Wenying Long, Lisi Dai, Panfeng Tao, Zhifen Deng… in Nature Communications (2024)

Article

The impact of continuous cultivation of Ganoderma lucidum on soil nutrients, enzyme activity, and fruiting body metabolites

To explore the impacts of continuous Ganoderma lucidum cultivation on soil physicochemical factors, soil enzyme activity, and the metabolome of Ganoderma lucidum fruiting bodies, this study conducted two consecut...

Wei Ji, Ni Zhang, Wenying Su, **a Wang, **aomei Liu, Yipu Wang… in Scientific Reports (2024)

Article

Status of self-medication and the relevant factors regarding drug efficacy and safety as important considerations among adolescents aged 12–18 in China: a cross-sectional study

The objective of this study was to investigate self-medication behavior among Chinese adolescents aged 12–18 years and explore the factors associated with whether adolescents prioritize drug efficacy or safety...

Diyue Liu, Pu Ge, **alei Li, Wenying Hong, Mengjie Huang, Lijun Zhu… in Scientific Reports (2024)

Article

Origin and dispersal history of Hepatitis B virus in Eastern Eurasia

Hepatitis B virus is a globally distributed pathogen and the history of HBV infection in humans predates 10000 years. However, long-term evolutionary history of HBV in Eastern Eurasia remains elusive. We prese...

Bing Sun, Aida Andrades Valtueña, Arthur Kocher, Shizhu Gao… in Nature Communications (2024)

Article

Linoleic acid induces human ovarian granulosa cell inflammation and apoptosis through the ER-FOXO1-ROS-NFκB pathway

Polycystic ovary syndrome (PCOS) is a complex reproductive endocrinological disorder influenced by a combination of genetic and environmental factors. Linoleic acid (LA) is a widely consumed ω-6 polyunsaturate...

Wenying Zhang, Fuju Wu in Scientific Reports (2024)

Article

Rationalizing kinetic behaviors of isolated boron sites catalyzed oxidative dehydrogenation of propane

Boron-based catalysts exhibit high alkene selectivity in oxidative dehydrogenation of propane (ODHP) but the mechanistic understanding remains incomplete. In this work, we show that the hydroxylation of framew...

Hao Tian, Wenying Li, Linhai He, Yunzhu Zhong, Shutao Xu, Hai **ao… in Nature Communications (2023)

Article

Single-cell transcriptome analysis indicates fatty acid metabolism-mediated metastasis and immunosuppression in male breast cancer

Male breast cancer (MBC) is a rare but aggressive malignancy with cellular and immunological characteristics that remain unclear. Here, we perform transcriptomic analysis for 111,038 single cells from tumor ti...

Handong Sun, Lishen Zhang, Zhonglin Wang, Danling Gu, Mengyan Zhu… in Nature Communications (2023)

Article

High-quality wild barley genome assemblies and annotation with Nanopore long reads and Hi-C sequencing data

Wild barley, from “Evolution Canyon (EC)” in Mount Carmel, Israel, are ideal models for cereal chromosome evolution studies. Here, the wild barley EC_S1 is from the south slope with higher daily temperatures a...

Rui Pan, Haifei Hu, Yuhui **ao, Le Xu, Yanhao Xu, Kai Ouyang… in Scientific Data (2023)

Article

24-Hour efficacy of single primary selective laser trabeculoplasty versus latanoprost eye drops for Naïve primary open-angle glaucoma and ocular hypertension patients

This prospective, observer-masked, randomized clinical trial was conducted between December 2018 and June 2021 at Eye Hospital, China Academy of Chinese Medical Sciences. A total of 45 glaucoma patients from B...

Yipeng Shi, Yan Zhang, Wenying Sun, Alex S. Huang, Shuang Chen… in Scientific Reports (2023)

Article

A neuromorphic bionic eye with filter-free color vision using hemispherical perovskite nanowire array retina

Spherical geometry, adaptive optics, and highly dense network of neurons bridging the eye with the visual cortex, are the primary features of human eyes which enable wide field-of-view (FoV), low aberration, e...

Zhenghao Long, **ao Qiu, Chak Lam Jonathan Chan, Zhibo Sun… in Nature Communications (2023)

Article

Applying T-classifier, binary classifiers, upon high-throughput TCR sequencing output to identify cytomegalovirus exposure history

With the continuous development of information technology and the running speed of computers, the development of informatization has led to the generation of increasingly more medical data. Solving unmet needs...

Kaiyue Zhou, Jiaxin Huo, Caixia Gao, Xu Wang, Pengfei Xu, Jiahuan Hou… in Scientific Reports (2023)

Article

Prognostic impact of examined lymph-node count for patients with esophageal cancer: development and validation prediction model

Esophageal cancer (EC) is a malignant tumor with high mortality. We aimed to find the optimal examined lymph node (ELN) count threshold and develop a model to predict survival of patients after radical esophag...

Shasha Yuan, Chen Wei, Mengyu Wang, Wenying Deng, Chi Zhang, Ning Li… in Scientific Reports (2023)

Article

Infancy, childhood, and puberty on the Silk Road revealed with isotopic analysis of incremental dentine

Childhood is a unique phase in human life history, in which newborns are breastfed and weaned, and are progressively familiarized to adult diets. By investigating dietary changes from infancy to adolescence, v...

Tingting Wang, Dong Wei, Bing Yi, Hongen Jiang, Wenying Li, Yaowu Hu… in Scientific Reports (2022)

Article

A phase 1b randomised controlled trial of a glucagon-like peptide-1 and glucagon receptor dual agonist IBI362 (LY3305677) in Chinese patients with type 2 diabetes

The success of glucagon-like peptide-1 (GLP-1) receptor agonists to treat type 2 diabetes (T2D) and obesity has sparked considerable efforts to develop next-generation co-agonists that are more effective. We c...

Hongwei Jiang, Shuguang Pang, Yawei Zhang, Ting Yu, Meng Liu… in Nature Communications (2022)

Article

Author Correction: A comprehensive characterization of the cell-free transcriptome reveals tissue- and subtype-specific biomarkers for cancer detection

Matthew H. Larson, Wenying Pan, Hyunsung John Kim, Ruth E. Mauntz… in Nature Communications (2022)

Article

Caltech Conte Center, a multimodal data resource for exploring social cognition and decision-making

This data release of 117 healthy community-dwelling adults provides multimodal high-quality neuroimaging and behavioral data for the investigation of brain-behavior relationships. We provide structural MRI, re...

Dorit Kliemann, Ralph Adolphs, Tim Armstrong, Paola Galdi, David A. Kahn… in Scientific Data (2022)

Article

Author Correction: A Cu(II)–ATP complex efficiently catalyses enantioselective Diels–Alder reactions

Changhao Wang, Qianqian Qi, Wenying Li, **gshuang Dang, Min Hao… in Nature Communications (2022)

Article

Clinical and genomic features of Chinese lung cancer patients with germline mutations

The germline mutation landscape in Chinese lung cancer patients has not been well defined. In this study, sequencing data of 1,021 cancer genes of 1,794 Chinese lung cancer patients was analyzed. A total of 11...

Wenying Peng, Bin Li, ** Li, Lianpeng Chang, **g Bai, Yuting Yi… in Nature Communications (2022)

Article

Study on the effect of koumiss on the intestinal microbiota of mice infected with Toxoplasma gondii

Toxoplasma gondii is a worldwide food-borne parasite that can infect almost all warm-blooded animals, including humans. To date, there are no effective drugs to prevent or eradicate T. gondii infection. Recent st...

**nlei Yan, Wenying Han, **ndong **, Yufei Sun, Jialu Gao, **uli Yu… in Scientific Reports (2022)

Article

Revealing lost secrets about Yingpan Man and the Silk Road

Yingpan Man, is one of the most exquisitely preserved mummies found in the **njiang Uyghur Autonomous Region of China. Here links between Yingpan Man and the Silk Road are explored through a detailed isotopic ...

Tingting Wang, Benjamin T. Fuller, Hongen Jiang, Wenying Li, Dong Wei… in Scientific Reports (2022)