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Open AccessLinear ubiquitination regulates the KSHV replication and transcription activator protein to control infection
Like many other viruses, KSHV has two life cycle modes: the latent phase and the lytic phase. The RTA protein from KSHV is essential for lytic reactivation, but how this protein’s activity is regulated is not ...
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Article
Open AccessThe impact of continuous cultivation of Ganoderma lucidum on soil nutrients, enzyme activity, and fruiting body metabolites
To explore the impacts of continuous Ganoderma lucidum cultivation on soil physicochemical factors, soil enzyme activity, and the metabolome of Ganoderma lucidum fruiting bodies, this study conducted two consecut...
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Open AccessStatus of self-medication and the relevant factors regarding drug efficacy and safety as important considerations among adolescents aged 12–18 in China: a cross-sectional study
The objective of this study was to investigate self-medication behavior among Chinese adolescents aged 12–18 years and explore the factors associated with whether adolescents prioritize drug efficacy or safety...
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Open AccessOrigin and dispersal history of Hepatitis B virus in Eastern Eurasia
Hepatitis B virus is a globally distributed pathogen and the history of HBV infection in humans predates 10000 years. However, long-term evolutionary history of HBV in Eastern Eurasia remains elusive. We prese...
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Open AccessLinoleic acid induces human ovarian granulosa cell inflammation and apoptosis through the ER-FOXO1-ROS-NFκB pathway
Polycystic ovary syndrome (PCOS) is a complex reproductive endocrinological disorder influenced by a combination of genetic and environmental factors. Linoleic acid (LA) is a widely consumed ω-6 polyunsaturate...
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Open AccessRationalizing kinetic behaviors of isolated boron sites catalyzed oxidative dehydrogenation of propane
Boron-based catalysts exhibit high alkene selectivity in oxidative dehydrogenation of propane (ODHP) but the mechanistic understanding remains incomplete. In this work, we show that the hydroxylation of framew...
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Article
Open AccessSingle-cell transcriptome analysis indicates fatty acid metabolism-mediated metastasis and immunosuppression in male breast cancer
Male breast cancer (MBC) is a rare but aggressive malignancy with cellular and immunological characteristics that remain unclear. Here, we perform transcriptomic analysis for 111,038 single cells from tumor ti...
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Open AccessHigh-quality wild barley genome assemblies and annotation with Nanopore long reads and Hi-C sequencing data
Wild barley, from “Evolution Canyon (EC)” in Mount Carmel, Israel, are ideal models for cereal chromosome evolution studies. Here, the wild barley EC_S1 is from the south slope with higher daily temperatures a...
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Open Access24-Hour efficacy of single primary selective laser trabeculoplasty versus latanoprost eye drops for Naïve primary open-angle glaucoma and ocular hypertension patients
This prospective, observer-masked, randomized clinical trial was conducted between December 2018 and June 2021 at Eye Hospital, China Academy of Chinese Medical Sciences. A total of 45 glaucoma patients from B...
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Open AccessA neuromorphic bionic eye with filter-free color vision using hemispherical perovskite nanowire array retina
Spherical geometry, adaptive optics, and highly dense network of neurons bridging the eye with the visual cortex, are the primary features of human eyes which enable wide field-of-view (FoV), low aberration, e...
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Open AccessApplying T-classifier, binary classifiers, upon high-throughput TCR sequencing output to identify cytomegalovirus exposure history
With the continuous development of information technology and the running speed of computers, the development of informatization has led to the generation of increasingly more medical data. Solving unmet needs...
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Open AccessPrognostic impact of examined lymph-node count for patients with esophageal cancer: development and validation prediction model
Esophageal cancer (EC) is a malignant tumor with high mortality. We aimed to find the optimal examined lymph node (ELN) count threshold and develop a model to predict survival of patients after radical esophag...
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Open AccessInfancy, childhood, and puberty on the Silk Road revealed with isotopic analysis of incremental dentine
Childhood is a unique phase in human life history, in which newborns are breastfed and weaned, and are progressively familiarized to adult diets. By investigating dietary changes from infancy to adolescence, v...
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Open AccessA phase 1b randomised controlled trial of a glucagon-like peptide-1 and glucagon receptor dual agonist IBI362 (LY3305677) in Chinese patients with type 2 diabetes
The success of glucagon-like peptide-1 (GLP-1) receptor agonists to treat type 2 diabetes (T2D) and obesity has sparked considerable efforts to develop next-generation co-agonists that are more effective. We c...
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Open AccessAuthor Correction: A comprehensive characterization of the cell-free transcriptome reveals tissue- and subtype-specific biomarkers for cancer detection
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Open AccessCaltech Conte Center, a multimodal data resource for exploring social cognition and decision-making
This data release of 117 healthy community-dwelling adults provides multimodal high-quality neuroimaging and behavioral data for the investigation of brain-behavior relationships. We provide structural MRI, re...
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Open AccessAuthor Correction: A Cu(II)–ATP complex efficiently catalyses enantioselective Diels–Alder reactions
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Open AccessClinical and genomic features of Chinese lung cancer patients with germline mutations
The germline mutation landscape in Chinese lung cancer patients has not been well defined. In this study, sequencing data of 1,021 cancer genes of 1,794 Chinese lung cancer patients was analyzed. A total of 11...
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Open AccessStudy on the effect of koumiss on the intestinal microbiota of mice infected with Toxoplasma gondii
Toxoplasma gondii is a worldwide food-borne parasite that can infect almost all warm-blooded animals, including humans. To date, there are no effective drugs to prevent or eradicate T. gondii infection. Recent st...
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Open AccessRevealing lost secrets about Yingpan Man and the Silk Road
Yingpan Man, is one of the most exquisitely preserved mummies found in the **njiang Uyghur Autonomous Region of China. Here links between Yingpan Man and the Silk Road are explored through a detailed isotopic ...