2,430 Result(s)

Article

The absorption of free vitamin B₁₂ and R protein-bound vitamin B₁₂ in the diagnosis of pancreatic exocrine insufficiency in rats

Vitamin B₁₂ (B₁₂) absorption was studied in rats following biliopancreatic duct ligation. The absorption of free B₁₂, as well as of hog R protein-bound B₁₂, was markedly impaired after both intragastric and intra...

Wen-Liang Chen, Reiji Morishita, Tadashi Eguchi… in International journal of pancreatology (1987)

Article

Variability in Declining Haloperidol and Reduced Haloperidol Plasma Concentrations upon Haloperidol Cessation

Plasma concentrations of haloperidol and its reduced metabolite were measured in 6 schizophrenic patients after discontinuation of oral haloperidol treatment. Patients were on haloperidol 10mg twice daily for ...

Shih-Ku Lin, Wen-Ho Chang, Y. W. Francis Lam, Dr Michael W. Jann in Drug Investigation (1993)

Article

Pharmacokinetics and Pharmacodynamics of Clozapine

The introduction of clozapine has given clinicians a unique agent for treating patients with schizophrenia that is refractory to other neuroleptics. Despite its efficacy, the drug continues to be prescribed wi...

Dr Michael W. Jann, Sara R. Grimsley, Eric C. Gray… in Clinical Pharmacokinetics (1993)

Article

Effects of Time of Administration and Posture on the Pharmacokinetics of Cefprozil

The effects of time of administration, sleep and posture on the pharmacokinetics of cefprozil were evaluated in a single-dose 3-way crossover study. After a 6-hour fast, 12 healthy male volunteers received ora...

Dr Wen Chyi Shyu, Carol R. Gleason, Rashmi H. Barbhaiya in Clinical Pharmacokinetics (1993)

Article

Formation of Reduced Haloperidol after Intramuscular Haloperidol Administration in Schizophrenic Patients

The formation of the reduced metabolite of haloperidol — reduced haloperidol (RH) — was evaluated after intramuscular haloperidol injection in 13 chronic schizophrenic patients. After an overnight fast, each p...

Michael W. Jann, Huang-Fuh Huang, Shih-Ku Lin, Dong-Juing Juang… in Drug Investigation (1994)

Article

Royal academy of medicine in Ireland section of biomedical sciences

C. M. Doolan, A. K. Keenan, C. M. Costello, K. McQuaid… in Irish Journal of Medical Science (1994)

Article

Lipid peroxidation and antioxidant vitamins C and E in hypertensive patients

Lipid peroxidation is a free radical process which is implicated in the formation of atherosclerosis. Vitamins C and E are important natural antioxidants which inhibit lipid peroxidation and a high intake of t...

Y. Wen, S. Killalea, P. McGettigan, J. Feely in Irish Journal of Medical Science (1996)

Article

Comparative Study of Teicoplanin vs Vancomycin for the Treatment of Methicillin-Resistant Staphylococcus aureus Bacteraemia

Forty patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia were randomised to receive either teicoplanin or vancomycin therapy to compare the clinical efficacy and safety of these glycopep...

Dr Cheng-Yi Liu, Wen-Sen Lee, Chang-Phone Fung… in Clinical Drug Investigation (1996)

Article

Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system

The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the alk (anaplastic lymphoma kinase) gene and the nuc...

Toshinori Iwahara, Jiro Fujimoto, Duanzhi Wen, Rod Cupples, Nathan Bucay… in Oncogene (1997)

Article

Function of reduced-size liver transplant in the rat

We have studied the function of partial orthotopic liver transplantation in the rat by evaluating prothrombin time (PT), liver blood flow, basal and glucose-stimulated insulin secretion and glucose tolerance, ...

Aksel Foss, Evita Zoucas, Friedrich Steinbauer… in Research in Experimental Medicine (1997)

Article

Serotonin (5-HT) stimulates thyrotropin-releasing hormone (TRH) gene transcription in rat embryonic cardiomyocytes

Thyrotropin-releasing hormone (TRH) and its mRNA have been identified in the rat heart, and TRH can enhance cardiomyocyte contractility in vivo. At present, little is known about cardiac TRH gene transcription...

Zhan **ang Shi, Wen Xu, Michael K. Selmanoff, John F. Wilber in Endocrine (1997)

Article

ESX: a structurally unique Ets overexpressed early during human breast tumorigenesis

The >30 known members of the Ets multigene family of transcriptional regulators are increasingly being recognized for their involvement in early embryonic development and late tissue maturation, directing stage-s...

Chuan-Hsiung Chang, Gary K Scott, Wen-Lin Kuo, **aohui **ong… in Oncogene (1997)

Article

Transforming activity and mitosis-related expression of the AKT2 oncogene: evidence suggesting a link between cell cycle regulation and oncogenesis

The AKT2 oncogene encodes a protein-serine/threonine kinase containing a pleckstrin homology domain characteristic of many signaling proteins. Recently, it was shown that AKT2 kinase activity can be induced by pl...

** Quan Cheng, Deborah A Altomare, Matias A Klein, Wen-Ching Lee, Gary D Kruh… in Oncogene (1997)

Article

γδ T-cell help in responses to pathogens and in the development of systemic autoimmunity

Mice rendered deficient in αβ T-cells by single-gene knockout mutation show enhanced levels of autoantibody formation and even some symptoms of autoimmune disease. This is remarkable given that most experiment...

Dr. Li Wen, Adrian C. Hayday in Immunologic Research (1997)

Article

ErbB kinases and NDF signaling in human prostate cancer cells

Prostate carcinoma (PCA) is the most commonly diagnosed malignancy in American men. Our knowledge of PCA growth regulation lags behind that of other cancers, such as breast and colon carcinomas. Among receptor...

Adam W Grasso, Duanzhi Wen, Casey M Miller, Johng S Rhim, Thomas G Pretlow… in Oncogene (1997)

Article

Dehydroepiandrosterone-sulfate (DHEAS) reduces adipocyte hyperplasia associated with feeding rats a high-fat diet

OBJECTIVE: To determine if chronic administration of a low level of dehydroepiandrosterone-sulfate (DHEAS) (10 µg/ml drinking water) attenuates adiposity in male Osborne-Mendel rats fed low-fat (11% of kcals) vs ...

YR Lea-Currie, P Wen, MK McIntosh in International Journal of Obesity (1997)

Article

Molecular analysis of the IL-2 receptor β chain gene expressed in human tumor cells

Interleukin-2 (IL-2) is recognized as a T cell growth factor. We have previously reported that human carcinoma cell lines are inhibited in growth by exogenous IL-2, which binds to the IL-2 receptor β (IL-2Rβ) ...

Yoshinori Suminami, Yoshiro Kashii, John C Law, Wen-Chang Lin, Joanna Stanson… in Oncogene (1998)