555 Result(s)
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Article
Human uracil–DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination
Activation-induced cytidine deaminase (AID) is a 'master molecule' in immunoglobulin (Ig) class-switch recombination (CSR) and somatic hypermutation (SHM) generation, AID deficiencies are associated with hyper...
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Article
Using support vector classification for SAR of fentanyl derivatives
To discriminate between fentanyl derivatives with high and low activities.
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Article
Intrathecal administration of roscovitine inhibits Cdk5 activity and attenuates formalin-induced nociceptive response in rats
To investigate effects of the cyclin-dependent kinase5 (Cdk5) inhibitor roscovitine on formalin-induced nociceptive responses in rats.
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Article
Hypoglycemic effect of Astragalus polysaccharide and its effect on PTP1B
To examine the effects of Astragalus polysaccharide (APS), a component of an aqueous extract of Astragalus membranaceus roots, on protein tyrosine phosphatase 1B (PTP1B), a negative regulator of insulin-receptor ...
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Article
Inhibition of STAT3 expression by siRNA suppresses growth and induces apoptosis in laryngeal cancer cells
To determine the inhibitory effect of the synthetic STAT3 siRNA on the expression of STAT3 gene in human laryngeal cancer cell lines Hep2 and to investigate the effect of STAT3 siRNA on growth and apoptosis in...
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Article
The anti-endotoxic effect of o-aminobenzoic acid from Radix Isatidis
To study the anti-endotoxic effect of o-aminobenzoic acid (OABA) isolated from Banlangen(BLG).
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Article
Transforming growth factor-β1 gene polymorphisms associated with chronic obstructive pulmonary disease in Chinese population
To determine the frequencies of polymorphism and haplotype in the transforming growth factor-beta 1 (TGF-β1) gene promoter in the Chinese population and to investigate the susceptibility of this population to ...
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Article
Relationship between leukocyte count and angiographical characteristics of coronary atherosclerosis
To explore the relationship between differential leucocyte count and coronary atherosclerosis.
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Article
Role of arachidonic acid in hyposmotic membrane stretch-induced increase in calcium-activated potassium currents in gastric myocytes
To study effects of arachidonic acid (AA) and its metabolites on the hyposmotic membrane stretch-induced increase in calcium-activated potassium currents (IKCa) in gastric myocytes.
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Article
Radioimmunotherapy of carcinoma of colon with [131I]- labeled recombinant chimeric monoclonal antibodies to carcinoembryonic antigen
To study the distribution of [131I]-labeled anti-CEA MoAbs and its therapeutic effect on the human colonic cancer model in nude mice.
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Article
A novel artemisinin derivative, 3-(12-β-artemisininoxy) phenoxyl succinic acid (SM735), mediates immunosuppressive effects in vitro and in vivo
To study the immunosuppressive activity of SM735 {[3 -(12-β-artemisininoxy)] phenoxyl succinic acid}, a synthetic artemisinin derivative with nonsteroidal anti-inflammatory drug structure, with the aim of find...
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Article
C16, a novel advanced glycation endproduct breaker, restores cardiovascular dysfunction in experimental diabetic rats
Advanced glycation endproducts (AGE) have been implicated in the pathogenesis of diabetic complications, including diabetic cardiovascular dysfunction. 3-[2-(4-Bromo-phenyl)-1-methyl-2-oxo-ethyl]-4,5,6,7-tetra...
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Article
Preparation and development of equine hyperimmune globulin F(ab′)2 against severe acute respiratory syndrome coronavirus
The resurgence of severe acute respiratory syndrome (SARS) is still a threat because the causative agent remaining in animal reservoirs is not fully understood, and sporadic cases continue to be reported. Deve...
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Article
Neuroprotective effects of stearic acid against toxicity of oxygen/glucose deprivation or glutamate on rat cortical or hippocampal slices
To observe the effects of stearic acid, a long-chain saturated fatty acid consisting of 18 carbon atoms, on brain (cortical or hippocampal) slices insulted by oxygen-glucose deprivation (OGD), glutamate or sod...
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Article
Relationship between atrial natriuretic peptide-immunoreactive cells and microvessels in rat gastric mucosa
To investigate the ultrastructural localization of atrial natriuretic peptide (ANP)-synthesizing cells and the relationship between ANP-synthesizing cells and microvessels in rat gastric mucosa.
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Article
cFLIP regulation of lymphocyte activation and development
Cellular caspase-8 (FLICE)-like inhibitory protein (cFLIP) is an enzymatically inert homologue of caspase-8 that competes with caspase-8 for recruitment to the...
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Article
Multiple dose pharmacokinetics of risperidone and 9-hydroxyrisperidone in Chinese female patients with schizophrenia
To study the multiple dose clinical pharmacokinetics of risperidone and its main active metabolite, 9-hydroxyrisperidone, in Chinese female patients with schizophrenia.
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Article
Electroporative interleukin-10 gene transfer ameliorates carbon tetrachloride-induced murine liver fibrosis by MMP and TIMP modulation
Liver fibrosis represents a process of healing and scarring in response to chronic liver injury. Effective therapies for liver fibrosis are lacking. Interleukin-10 (IL-10) is a cytokine that downregulates pro-...
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Article
Induction of collateral artery growth and improvement of post-infarct heart function by hepatocyte growth factor gene transfer
To study the effect of adenovirus5-mediated human hepatocyte growth factor (Ad5-HGF) transfer on post-infarct heart failure in a swine model.
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Article
Role of 11-beta-hydroxysteroid dehydrogenase type 1 in differentiation of 3T3-L1 cells and in rats with diet-induced obesity
To observe the roles of 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in in vitro preadipocyte differentiation and in rats with diet-induced obesity (DIO).
