12 Result(s)
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Article
Trevor C. McMorris
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Synergy of irofulven in combination with other DNA damaging agents: synergistic interaction with altretamine, alkylating, and platinum-derived agents in the MV522 lung tumor model
Irofulven (MGI 114, NSC 683863) is a semisynthetic derivative of illudin S, a natural product present in the Omphalotus illudins (Jack O’Lantern) mushroom. This novel agent produces DNA damage, that in contrast t...
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Synergy of Irofulven in combination with various anti-metabolites, enzyme inhibitors, and miscellaneous agents in MV522 lung carcinoma cells: marked interaction with gemcitabine and 5-fluorouracil
The novel agent Irofulven (HMAF, NSC 683863) has demonstrated significant antitumor activity against solid tumors in various xenograft models and human clinical trials. The antitumor potential of combining iro...
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Enhanced Antitumor Activity of Irofulven in Combination with Antimitotic Agents
The aim of this study was to determine theantitumor activity of irofulven whenadministered in combination with a varietyof antimitotic agents. Irofulven incombination with either paclitaxel ordocetaxel demonst...
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Enhanced antitumor activity of irofulven in combination with thiotepa or mitomycin C
Purpose: Irofulven (6-hydroxymethylacylfulvene, MGI 114, NSC 683863) is a semisynthetic derivative of illudin S, a toxin present in the Omphalotus mushroom. Irofulven has demonstrated activity against a broad ran...
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Characterization of MGI 114 (HMAF) histiospecific toxicity in human tumor cell lines
Purpose: The acylfulvenes are a class of antitumor agents derived from the fungal toxin illudin S. One acylfulvene derivative, MGI 114 (HMAF), demonstrates marked efficacy in xenograft carcinoma models when comp...
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Recent developments in the field of plant steroid hormones
Brassinolide and related brassinosteroids are a novel group of steroids which appear to be ubiquitous in plants. There is compelling evidence, particularly from recent genetic studies, that these steroids are ...
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Characterization of acylfulvene histiospecific toxicity in human tumor cell lines
Purpose: Acylfulvene derivatives demonstrate marked efficacy in xenograft carcinoma models as compared with the parent illudin compounds. To elucidate the increased therapeutic efficacy of acylfulvene analogs, w...
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Characterization of cellular accumulation and toxicity of illudin S in sensitive and nonsensitive tumor cells
Illudins are novel low molecular weight natural products cytotoxic to human tumor cells in vitro. Illudin-derived analogs are effective against experimental human cancers nonresponsive to conventional antican...
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Efficacy of HMAF (MGI-114) in the MV522 metastatic lung carcinoma xenograft model nonresponsive to traditional anticancer agents
Illudin analogs are cytotoxic to a variety of multidrug resistant cell lines, and display an unusual toxicity towards DNA helicase-deficient cell lines. Earlier illudin analogs demonstrated efficacy in several...
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Physiological and molecular effects of brassinosteroids on Arabidopsis thaliana
We examined the effects of brassinosteroids on Arabidopsis thaliana (L.) Henyh. ecotype Columbia in order to develop a model system for studying gene regulation by plant steroids. Submicromolar concentrations of ...
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Studies on the biosynthesis of the oogoniols
In feeding experiments withAchlya heterosexualis, [3-3H] fucosterol was efficiently incorporated into oogoniols possessing an unsaturated side chain as well as those with a saturated side chain (clionasterol skel...
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Sex hormones of the aquatic fungusAchlya
Fungi in the order Saprolegniales are known to contain varying proportions of sterols, such as cholesterol and fucosterol. In the caseAchyla, it has been found that fucosterol, the major sterol component, serves ...
