177 Result(s)
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Article
Tao **ong
Life Sciences
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Article
Combined application of organic wastes and Trichoderma longibraciatum to promote vegetation restoration and soil quality on mining waste dump sites
Vitamin C industrial organic fermentation waste—residue after evaporation (RAE) and Trichoderma longibraciatum (TL) can provide organic acids and microorganisms for soil amendment. This study assessed the feasibi...
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Molecular and physiological evidence of HvCaLB1 regulates calcium homeostasis and salt tolerance in Barley
The loss of crop productivity due to soil salinity is an increasing threat to agriculture worldwide. Calcium (Ca2+) plays vital roles in salt-responsive signaling through the perception of various calcium-binding...
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Open AccessStomach as the target organ of Rickettsia heilongjiangensis infection in C57BL/6 mice identified by click chemistry
Spotted fever group rickettsiae (SFGR) are obligate intracellular bacteria that cause spotted fever. The limitations of gene manipulation pose great challenges to studying the infection mechanisms of Rickettsia. ...
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Open AccessThe global distribution of the macrolide esterase EstX from the alpha/beta hydrolase superfamily
Macrolide antibiotics, pivotal in clinical therapeutics, are confronting resistance challenges mediated by enzymes like macrolide esterases, which are classified into Ere-type and the less studied Est-type. In...
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Open AccessMultiomics integration-based immunological characterizations of adamantinomatous craniopharyngioma in relation to keratinization
Although adamantinomatous craniopharyngioma (ACP) is a tumour with low histological malignancy, there are very few therapeutic options other than surgery. ACP has high histological complexity, and the unique f...
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Improvement of thermostability by increasing rigidity in the finger regions and flexibility in the catalytic pocket area of Pseudoalteromonas porphyrae κ-carrageenase
Poor thermostability reduces the industrial application value of κ-carrageenase. In this study, the PoPMuSiC algorithm combined with site-directed mutagenesis was applied to improve the thermostability of the ...
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Open AccessE3 ubiquitin ligase UBR5 promotes gemcitabine resistance in pancreatic cancer by inducing O-GlcNAcylation-mediated EMT via destabilization of OGA
Pancreatic cancer (PC) is among the deadliest malignancies, with an extremely poor diagnosis and prognosis. Gemcitabine (GEM) remains the first-line drug for treating PC; however, only a small percentage of pa...
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Open AccessComparative whole-genome resequencing to uncover selection signatures linked to litter size in Hu Sheep and five other breeds
Hu sheep (HS), a breed of sheep carrying the FecB mutation gene, is known for its “year-round estrus and multiple births” and is an ideal model for studying the high fecundity mechanisms of livestock. Through ana...
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USF2 activates RhoB/ROCK pathway by transcriptional inhibition of miR-206 to promote pyroptosis in septic cardiomyocytes
Septic cardiomyopathy (SCM) is one of the most serious complications of sepsis. The present study investigated the role and mechanism of upstream stimulatory factor 2 (USF2) in SCM. Serum samples were extracte...
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Allelopathy research on the continuous crop** problem of poplar (populus)
The mechanism of decline in continuous plantations is currently a popular research topic in forestry. Continuous crop** is a common obstacle in poplar production and management, and maintaining productivity ...
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Open AccessOrigin, evolution, and diversification of inositol 1,4,5-trisphosphate 3-kinases in plants and animals
In Eukaryotes, inositol polyphosphates (InsPs) represent a large family of secondary messengers and play crucial roes in various cellular processes. InsPs are synthesized through a series of pohophorylation re...
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miR-206 alleviates LPS-induced inflammatory injury in cardiomyocytes via directly targeting USP33 to inhibit the JAK2/STAT3 signaling pathway
Previous reports have confirmed that miR-206 participates in inflammatory cardiomyopathy, but its definite mechanism remains elusive. This study aims to elucidate the potential mechanism of miR-206 in septic c...
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Open AccessFBXO22 promotes glioblastoma malignant progression by mediating VHL ubiquitination and degradation
Glioblastoma (GBM) is the most common malignant primary brain tumor. Despite comprehensive treatment with traditional surgery, radiotherapy, and chemotherapy, the median survival rate is <14.6% and the 5-year ...
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Open AccessLipid metabolism and MAPK-ICE1 cascade play crucial roles in cold tolerance of banana
Low temperature is a major environmental factor that limits the growth, yield, and geographical distribution of Cavendish and Dajiao bananas (Musa spp.). Dajiao bananas exhibit a significantly higher cold toleran...
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Open AccessGenome-wide analysis of the switchgrass YABBY family and functional characterization of PvYABBY14 in response to ABA and GA stress in Arabidopsis
The small YABBY plant-specific transcription factor has a prominent role in regulating plant growth progress and responding to abiotic stress.
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Gut Distribution, Impact Factor, and Action Mechanism of Bacteriocin-Producing Beneficial Microbes as Promising Antimicrobial Agents in Gastrointestinal Infection
Gastrointestinal (GI) infection by intestinal pathogens poses great threats to human health, and the therapeutic use of antibiotics has reached a bottleneck due to drug resistance. The developments of antimicr...
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Correction: miR-206 alleviates LPS-induced inflammatory injury in cardiomyocytes via directly targeting USP33 to inhibit the JAK2/STAT3 signaling pathway
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Open AccessIntegrating genomic sequencing resources: an innovative perspective on recycling with universal Angiosperms353 probe sets
Sequencing strategies have continually advanced, with high-throughput sequencing (HTS) technologies emerging as pivotal tools in plant phylogenomics. As a standard form of target capture sequencing, hybridizat...
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Genomic, Physiological, Biochemical, and Phenotypic Evidences Reveal a New Species, Halomicroarcula salaria sp. nov
An extremely halophilic archaeon strain named FL173T was isolated from a salt mine (Anhui Province, China). Colonies on agar plate are orange-red, moist, and opaque. Cells are motile, Gram-stain-negative, polymor...
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Open AccessImproving the thermostability of Pseudoalteromonas Porphyrae κ-carrageenase by rational design and MD simulation
The industrial applications of the κ-carrageenases have been restricted by their poor thermostability. In this study, based on the folding free energy change (ΔΔG) and the flexibility analysis using molecular ...
