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Dendritic cells and T cells deliver oncolytic reovirus for tumour killing despite pre-existing anti-viral immunity

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  1. Article

    Prime-boost using separate oncolytic viruses in combination with checkpoint blockade improves anti-tumour therapy

    The anti-tumour effects associated with oncolytic virus therapy are mediated significantly through immune-mediated mechanisms, which depend both on the type of virus and the route of delivery. Here, we show th...

    E Ilett, T Kottke, J Thompson, K Rajani, S Zaidi, L Evgin, M Coffey… in Gene Therapy (2017)

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  2. Article

    Single-cycle viral gene expression, rather than progressive replication and oncolysis, is required for VSV therapy of B16 melanoma

    A fully intact immune system would be expected to hinder the efficacy of oncolytic virotherapy by inhibiting viral replication. Simultaneously, however, it may also enhance antitumor therapy through initiation...

    F Galivo, R M Diaz, P Wongthida, J Thompson, T Kottke, G Barber, A Melcher… in Gene Therapy (2010)

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