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Article
Open AccessIntegrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons
Autophagy is a conserved, catabolic process essential for maintaining cellular homeostasis. Malfunctional autophagy contributes to neurodevelopmental and neurodegenerative diseases. However, the exact role and...
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Article
Open AccessSelective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines
Molecular-glue degraders are small molecules that induce a specific interaction between an E3 ligase and a target protein, resulting in the target proteolysis. The discovery of molecular glue degraders current...
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Article
Open AccessEndoscopic surgery versus intensity-modulated radiotherapy in locally advanced recurrent nasopharyngeal carcinoma: a multicenter, case-matched comparison
The management of locally advanced recurrent nasopharyngeal carcinoma (rNPC) is challenging. The objective of our study was to compare salvage endoscopic nasopharyngectomy (ENPG) with intensity-modulated radio...
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Article
Facile Fabrication of Cotton-Based Thermoelectric Yarns for the Construction of Textile Generator with High Performance in Human Heat Harvesting
Thermoelectric (TE) textiles which can harvest thermal energy from the human body, are highly desirable and vital to the charging of wearable electronics owing to their stable and long-term power output. The t...
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Open AccessPRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells
Programmed death receptor-1 (PD-1) blockade have achieved some efficacy but only in a fraction of patients with hepatocellular carcinoma (HCC). Programmed cell death 1 ligand 1 (PD-L1) binds to its receptor PD...
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Article
Open AccessGenetic architecture of protein expression and its regulation in the mouse brain
Natural variation in protein expression is common in all organisms and contributes to phenotypic differences among individuals. While variation in gene expression at the transcript level has been extensively i...
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Article
Open Accessp63+Krt5+ basal cells are increased in the squamous metaplastic epithelium of patients with radiation-induced chronic Rhinosinusitis
Squamous metaplasia (SM) is an irreversible form of airway epithelial remodeling. Hyperproliferation of basal cells was observed in squamous metaplastic epithelium of chronically inflamed airway. However, the ...
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Article
A micro monolithic integrated force-torque sensor with piezoelectric tuning mechanism
A novel micro force-torque sensor with tuning mechanism is presented in this paper. The sensor is designed and fabricated based on monolithic integrated method, including planar graphic manufacturing and lamin...
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Open AccessLessons from an active surveillance pilot to assess the pneumonia of unknown etiology surveillance system in China, 2016: the need to increase clinician participation in the detection and reporting of emerging respiratory infectious diseases
We sought to assess reporting in China’s Pneumonia of Unknown Etiology (PUE) passive surveillance system for emerging respiratory infections and to identify ways to improve the PUE surveillance system’s detect...
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Article
Open AccessDeep multiomics profiling of brain tumors identifies signaling networks downstream of cancer driver genes
High throughput omics approaches provide an unprecedented opportunity for dissecting molecular mechanisms in cancer biology. Here we present deep profiling of whole proteome, phosphoproteome and transcriptome ...
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Article
Open AccessYAP promotes the malignancy of endometrial cancer cells via regulation of IL-6 and IL-11
Emerging evidence shows that Hippo signal pathways can regulate the progression of various cancer. While the roles of Yes-associated protein (YAP), the key transducer of Hippo signals, in the development of en...
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Open AccessA ten-year China-US laboratory collaboration: improving response to influenza threats in China and the world, 2004–2014
The emergence of severe acute respiratory syndrome (SARS) underscored the importance of influenza detection and response in China. From 2004, the Chinese National Influenza Center (CNIC) and the United States ...
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Piezoelectric-driven miniature wheeled robot based on flexible transmission mechanisms
A 935 mg weight coin-size piezoelectric-driven wheeled robot with a flexible body-actuator-transmission integrated structure is presented in this paper. The robot is monolithic designed and fabricated via plan...
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Open AccessSuperparamagnetic Fe3O4-PEG2K-FA@Ce6 Nanoprobes for in Vivo Dual-mode Imaging and Targeted Photodynamic Therapy
The development of targeted nanoprobes is a promising approach to cancer diagnostics and therapy. In the present work, a novel multifunctional photo/magnet-diagnostic nanoprobe (MNPs-PEG2K-FA@Ce6) has been develo...
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Open AccessInfluenza-associated outpatient visits among children less than 5 years of age in eastern China, 2011–2014
The disease burden of influenza in China has not been well described, especially among young children. The aim of this study was to estimate the incidence of outpatient visits associated with influenza in youn...
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Article
Analysis of an efficient rule-based motion planning system for simulating human crowds
This paper proposes a rule-based motion planning system for agent-based crowd simulation, consisting of sets of rules for both collision avoidance and collision response. In order to avoid an oncoming collisio...
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Article
Women’s Postpartum Practices and Chronic Pain in Rural China
Objectives The aims of this study were to describe women’s traditional postpartum practice and chronic pain, and to explore the relationship between them. Methods In this cross-sectional ...
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Article
Structure of oxidized α-haemoglobin bound to AHSP reveals a protective mechanism for haem
Free α-haemoglobin exists as a structurally unstable monomer and is prone to oxidation and precipitation, contributing to the pathophysiology of β-thalassaemia and other blood disorders. Molecular chaperones h...
