6 Result(s)
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Article
Open AccessAmygdala subdivisions exhibit aberrant whole-brain functional connectivity in relation to stress intolerance and psychotic symptoms in 22q11.2DS
The amygdala is a key region in emotional regulation, which is often impaired in psychosis. However, it is unclear if amygdala dysfunction directly contributes to psychosis, or whether it contributes to psycho...
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Article
Open AccessContribution of schizophrenia polygenic burden to longitudinal phenotypic variance in 22q11.2 deletion syndrome
While the recurrent 22q11.2 deletion is one of the strongest genetic risk factors for schizophrenia (SCZ), variability of its associated neuropsychiatric endophenotypes reflects its incomplete penetrance for p...
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Article
Open AccessAltered cortical thickness development in 22q11.2 deletion syndrome and association with psychotic symptoms
Schizophrenia has been extensively associated with reduced cortical thickness (CT), and its neurodevelopmental origin is increasingly acknowledged. However, the exact timing and extent of alterations occurring...
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Article
Open AccessLong-term effects of early treatment with SSRIs on cognition and brain development in individuals with 22q11.2 deletion syndrome
Cognitive deficits in individuals at risk of psychosis represent a significant challenge for research, as current strategies for symptomatic treatment are often ineffective. Recent studies showed that atypical...
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Article
Open AccessIdentifying neurodevelopmental anomalies of white matter microstructure associated with high risk for psychosis in 22q11.2DS
Disruptions of white matter microstructure have been widely reported in schizophrenia. However, the emergence of these alterations during preclinical stages remains poorly understood. 22q11.2 Deletion Syndrome...
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Article
Open AccessAbnormal development of early auditory processing in 22q11.2 Deletion Syndrome
The 22q11.2 Deletion Syndrome (22q11.2 DS) is one of the highest genetic risk factors for the development of schizophrenia spectrum disorders. In schizophrenia, reduced amplitude of the frequency mismatch nega...
