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Open AccessGenetic diversity of variants involved in drug response among Tunisian and Italian populations toward personalized medicine
Adverse drug reactions (ADR) represent a significant contributor to morbidity and mortality, imposing a substantial financial burden. Genetic ancestry plays a crucial role in drug response. The aim of this stu...
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Open AccessEthnic and functional differentiation of copy number polymorphisms in Tunisian and HapMap population unveils insights on genome organizational plasticity
Admixture map** has been useful in identifying genetic variations linked to phenotypes, adaptation and diseases. Copy number variations (CNVs) represents genomic structural variants spanning large regions of...
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Open AccessPrevalence and risk factors of diabetes mellitus and hypertension in North East Tunisia calling for efficient and effective actions
Diabetes and hypertension are a serious public health problem worldwide. In the last decades, prevalence of these two metabolic diseases has dramatically increased in the Middle East and North Africa region, e...
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Open AccessInflammatory landscape in Xeroderma pigmentosum patients with cutaneous melanoma
Xeroderma pigmentosum (XP) is a DNA repair disease that predisposes to early skin cancers as cutaneous melanoma. Melanoma microenvironment contains inflammatory mediators, which would be interesting biomarkers...