26 Result(s)

Article

Efficacy and safety of mineralocorticoid receptor antagonists for patients with heart failure and diabetes mellitus: a systematic review and meta-analysis

The aim of this study was to systematically assess the efficacy and safety of mineralocorticoid receptor antagonists (MRAs) for patients with heart failure (HF) and diabetes mellitus (DM).

Meng-Die Chen, Si-Si Dong, Ning-Yu Cai, Meng-Di Fan… in BMC Cardiovascular Disorders (2016)

Article

Omentin-1 prevents inflammation-induced osteoporosis by downregulating the pro-inflammatory cytokines

Osteoporosis is a frequent complication of chronic inflammatory diseases and increases in the pro-inflammatory cytokines make an important contribution to bone loss by promoting bone resorption and impairing b...

Shan-Shan Rao, Yin Hu, **-Li **e, Jia Cao, Zhen-**ng Wang, Jiang-Hua Liu… in Bone Research (2018)

Article

Extracellular vesicles from human urine-derived stem cells prevent osteoporosis by transferring CTHRC1 and OPG

Osteoporosis is a debilitating bone disease affecting millions of people. Here, we used human urine-derived stem cells (USCs), which were noninvasively harvested from unlimited and easily available urine, as a...

Chun-Yuan Chen, Shan-Shan Rao, Yi-Juan Tan, Ming-Jie Luo, **ong-Ke Hu… in Bone Research (2019)

Article

The flavonoid-rich Quzhou Fructus Aurantii extract modulates gut microbiota and prevents obesity in high-fat diet-fed mice

Flavonoids are reported to modulate the composition of gut microbiota, which play an important role in preventing obesity and associated metabolic diseases. In this study, we investigated the effect of Total F...

Yong-feng Bai, Si-wei Wang, **ao-xiao Wang, Yuan-yuan Weng… in Nutrition & Diabetes (2019)

Article

Neohesperidin enhances PGC-1α-mediated mitochondrial biogenesis and alleviates hepatic steatosis in high fat diet fed mice

Mitochondria plays a critical role in the development and pathogenesis of nonalcoholic fatty liver disease (NAFLD). Neohesperidin (NHP) could lower blood glucose and prevent obesity in mice. However, the direc...

Si-wei Wang, Hao Sheng, Yong-feng Bai, Yuan-yuan Weng, Xue-yu Fan… in Nutrition & Diabetes (2020)

Article

Validation of nomogram-revised risk index and comparison with other models for extranodal nasal-type NK/T-cell lymphoma in the modern chemotherapy era: indication for prognostication and clinical decision-making

Derived from our original nomogram study by using the risk variables from multivariable analyses in the derivation cohort of 1383 patients with extranodal NK/T-cell lymphoma, nasal-type (ENKTCL) who were mostl...

Si-Ye Chen, Yong Yang, Shu-Nan Qi, Ying Wang, Chen Hu, **a He, Li-Ling Zhang… in Leukemia (2021)

Article

Safety and immunogenicity of a recombinant COVID-19 vaccine (Sf9 cells) in healthy population aged 18 years or older: two single-center, randomised, double-blind, placebo-controlled, phase 1 and phase 2 trials

COVID-19 vaccines from multiple manufacturers are needed to cope with the problem of insufficient supply. We did two single-center, randomised, double-blind, placebo-controlled phase 1 and phase 2 trials to as...

Fan-Yue Meng, Fan Gao, Si-Yue Jia… in Signal Transduction and Targeted Therapy (2021)

Article

Home-based transcutaneous electrical acupoint stimulation for hypertension: a randomized controlled pilot trial

The aim of this trial was to evaluate the feasibility and effect of home-based transcutaneous electrical acupoint stimulation (TEAS) in patients with hypertension. In this randomized pilot trial, patients with...

Jian-Feng Tu, Li-Qiong Wang, Jun-Hong Liu, You-Sheng Qi… in Hypertension Research (2021)

Article

Tobacco carcinogen induces tryptophan metabolism and immune suppression via induction of indoleamine 2,3-dioxygenase 1

Indoleamine 2,3-dioxygenase 1 (IDO1), the enzyme that catabolizes tryptophan (Trp) metabolism to promote regulatory T cells (Tregs) and suppress CD8⁺ T cells, is regulated by several intrinsic signaling pathways....

Fan Liang, Gui-Zhen Wang, Yan Wang… in Signal Transduction and Targeted Therapy (2022)

Article

Meplazumab in hospitalized adults with severe COVID-19 (DEFLECT): a multicenter, seamless phase 2/3, randomized, third-party double-blind clinical trial

Meplazumab, a humanized CD147 antibody, has shown favourable safety and efficacy in our previous clinical studies. In DEFLECT (NCT04586153), 167 patients with severe COVID-19 were enroled and randomized to rec...

Huijie Bian, Liang Chen, Zhao-Hui Zheng… in Signal Transduction and Targeted Therapy (2023)

Article

Erlotinib versus gemcitabine plus cisplatin as neoadjuvant treatment of stage IIIA-N2 EGFR-mutant non-small-cell lung cancer: final overall survival analysis of the EMERGING-CTONG 1103 randomised phase II trial

EMERGING-CTONG 1103 showed improved progression-free survival (PFS) with neoadjuvant erlotinib vs. chemotherapy for patients harbouring EGFR sensibility mutations and R0 resected stage IIIA-N2 non-small cell l...

Wen-Zhao Zhong, Hong-Hong Yan, Ke-Neng Chen… in Signal Transduction and Targeted Therapy (2023)

Article

Regeneration and functional recovery of the completely transected optic nerve in adult rats by CNTF-chitosan

**ao Liu, Fei Hao, Peng Hao, **gxue Zhang… in Signal Transduction and Targeted Therapy (2023)

Article

Noninvasive assessment of myocardial work during left ventricular isovolumic relaxation in patients with diastolic dysfunction

This study aims to investigate the value of myocardial work (MW) parameters during the isovolumic relaxation (IVR) period in patients with left ventricular diastolic dysfunction (LVDD).

Ying Guo, **ang Wang, Chen-guang Yang, Xu-yang Meng, Yi Li… in BMC Cardiovascular Disorders (2023)

Article

Nuclear AhR and membranous PD-L1 in predicting response of non-small cell lung cancer to PD-1 blockade

Si-Chong Han, Gui-Zhen Wang, Ya-Ning Yang… in Signal Transduction and Targeted Therapy (2023)

Article

Soluble CD4 effectively prevents excessive TLR activation of resident macrophages in the onset of sepsis

T lymphopenia, occurring in the early phase of sepsis in response to systemic inflammation, is commonly associated with morbidity and mortality of septic infections. We have previously shown that a sufficient ...

Sheng-yuan Zhang, Qiu-** Xu, Li-na Shi… in Signal Transduction and Targeted Therapy (2023)

Article

Effects of mixed oil emulsion on short-term clinical outcomes in premature infants: A prospective, multicenter, randomized controlled trial

This study compared the clinical effects of two different lipid emulsions in premature infants with gestational age < 32 weeks (VPI) or birth weight < 1500 g (VLBWI) to provide an evidence-based medicine basis...

Qing Yang, Juan Kong, Rui-Miao Bai, Wen-Ting Yu… in European Journal of Clinical Nutrition (2023)

Article

Dynamic single-cell map** unveils Epstein‒Barr virus-imprinted T-cell exhaustion and on-treatment response

Epstein‒Barr virus (EBV)-associated gastric cancer (GC) manifests an intriguing immunotherapy response. However, the cellular basis for EBV-imprinted tumour immunity and on-treatment response remains undefined...

Miao-Zhen Qiu, Chaoye Wang, Zhiying Wu, Qi Zhao… in Signal Transduction and Targeted Therapy (2023)

Article

Metatranscriptome of human lung microbial communities in a cohort of mechanically ventilated COVID-19 Omicron patients

The Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infected a substantial proportion of Chinese population, and understanding the factors underlying the severity of the dis...

Lin Wang, Jia-Bao Cao, Bin-Bin **a, Yue-Juan Li… in Signal Transduction and Targeted Therapy (2023)

Article

Neoadjuvant nivolumab with or without platinum-doublet chemotherapy based on PD-L1 expression in resectable NSCLC (CTONG1804): a multicenter open-label phase II study

This prospective multicenter phase II study evaluated the clinical efficacy of neoadjuvant nivolumab-exclusive (N) and nivolumab–chemotherapy (N/C) combinations based on PD-L1 expression. Eligible patients exh...

Si-Yang Liu, Song Dong, Xue-Ning Yang… in Signal Transduction and Targeted Therapy (2023)