42 Result(s)

Article

FHL1C induces apoptosis in notch1-dependent T-ALL cells through an interaction with RBP-J

Aberrantly activated Notch signaling has been found in more than 50% of patients with T-cell acute lymphoblastic leukemia (T-ALL). Current strategies that employ γ-secretase inhibitors (GSIs) to target Notch a...

Wei Fu, Kai Wang, Jun-Long Zhao, Heng-Chao Yu, San-Zhong Li, Yan Lin… in BMC Cancer (2014)

Article

The effects of psychological interventions on depression and anxiety among Chinese adults with cancer: a meta-analysis of randomized controlled studies

Our previous studies found the high prevalence of depression and anxiety among Chinese cancer patients, and many empirical studies have been conducted to evaluate the effects of psychological interventions on ...

Yi-Long Yang, Guo-Yuan Sui, Guang-Cong Liu, De-Sheng Huang, Si-Meng Wang… in BMC Cancer (2014)

Article

Polymorphisms in FADS1 and FADS2 alter plasma fatty acids and desaturase levels in type 2 diabetic patients with coronary artery disease

To explore whether plasma fatty acids and SNPs in the fatty acid desaturase (FADS) gene associated with type 2 diabetes (T2D) and coronary artery disease (CAD).

Si-Wei Li, ** Wang, Ying Yang, Zhi-Jie Liu, Lin Cheng… in Journal of Translational Medicine (2016)

Article

Foxp3 overexpression in tumor cells predicts poor survival in oral squamous cell carcinoma

Forkhead Box P3 (Foxp3) is a regulatory T cells marker, and its expression correlates with prognosis in a number of malignancies. The aim of this study is to determine the relationship of Foxp3 expression with...

**g-**g Song, Si-Jia Zhao, Juan Fang, Da Ma, **ang-Qi Liu, **ao-Bing Chen… in BMC Cancer (2016)

Article

A multicenter, randomized, double-blind, placebo-controlled trial evaluating the efficacy and safety of Tong Luo Hua Shi capsule, a modernized Tibetan medicine, in patients with rheumatoid arthritis

Tong Luo Hua Shi (TLHS) is a new formulation of the traditional Tibetan medicine Wu-wei-gan-lu that has been used for the treatment of rheumatoid arthritis (RA) for hundreds of years in China. This study aimed...

Wei Liu, Yuan-Hao Wu, Si-Yuan Hu, Cheng-Liang Zhong, Ming-Li Gao, Dong-Wu Liu… in Trials (2016)

Article

Identification of endonuclease domain-containing 1 as a novel tumor suppressor in prostate cancer

Endonuclease domain containing 1 (ENDOD1) is implicated in tumorigenesis and aggressiveness of multiple tumors. In this study, we aimed to investigate the role of ENDOD1 in prostate cancer (PCa).

Jianguang Qiu, Shubin Peng, Jie Si-Tu, Cheng Hu, Wentao Huang, Yunhua Mao… in BMC Cancer (2017)

Article

Erratum to: Identification of endonuclease domain-containing 1 as a novel tumor suppressor in prostate cancer

Jianguang Qiu, Shubin Peng, Jie Si-Tu, Cheng Hu, Wentao Huang, Yunhua Mao… in BMC Cancer (2017)

Article

The detrimental effects of radiotherapy interruption on local control after concurrent chemoradiotherapy for advanced T-stage nasopharyngeal carcinoma: an observational, prospective analysis

Previous studies have reported radiotherapy interruption (RTI) is associated with poor local control in two-dimensional radiotherapy (2DRT) era. However, it remains unclear whether RTI still affects local cont...

Ji-** Yao, Ya-Nan **, Si-Yang Wang, Fan Zhang, Guan-Qun Zhou… in BMC Cancer (2018)

Article

The changes of immunoglobulin G N-glycosylation in blood lipids and dyslipidaemia

Alternative N-glycosylation has significant structural and functional consequences on immunoglobulin G (IgG) and can affect immune responses, acting as a switch between pro- and anti-inflammatory IgG functionalit...

Di Liu, ** Chu, Hao Wang, **g Dong, Si-Qi Ge… in Journal of Translational Medicine (2018)

Article

Prognostic value of neutrophil-to-lymphocyte ratio in advanced nasopharyngeal carcinoma: a large institution-based cohort study from an endemic area

Findings remain unclear whether neutrophil-to-lymphocyte ratio (NLR) detrimentally affects advanced nasopharyngeal carcinoma (NPC) prognosis. We aim to evaluate the prognostic value of NLR in patients with NPC...

Ji-** Yao, Feng-Ting Zhu, Jun Dong, Zi-Bin Liang, Le-Wei Yang, Shao-Yi Chen… in BMC Cancer (2019)

Article

Efficacy and safety of levothyroxine (L-T4) replacement on the exercise capability in chronic systolic heart failure patients with subclinical hypothyroidism: Study protocol for a multi-center, open label, randomized, parallel group trial (ThyroHeart-CHF)

Subclinical hypothyroidism is a common condition in patients with heart failure and is defined as elevated serum thyroid hormone (TSH) with normal circulating free thyroxine (FT4). Evidence on the effect of th...

Xuan Zhang, Wen-yao Wang, Kuo Zhang, Jian Tian, Ji-lin Zheng, **g Chen… in Trials (2019)

Article

Pretreatment risk management of a novel nomogram model for prediction of thoracoabdominal extrahepatic metastasis in primary hepatic carcinoma

Extrahepatic metastasis is the independent risk factor of poor survival of primary hepatic carcinoma (PHC), and most occurs in the chest and abdomen. Currently, there is still no available method to predict th...

Jia Hu, Ting Wang, Kun-He Zhang, Yi-** Jiang… in Journal of Translational Medicine (2019)

Article

Phase I study of high-dose ascorbic acid with mFOLFOX6 or FOLFIRI in patients with metastatic colorectal cancer or gastric cancer

Preclinical studies suggest synergistic effectiveness of ascorbic acid (AA, vitamin C) and cytotoxic agents in gastrointestinal malignancies. This phase 1 study aimed to establish the maximum tolerated dose (M...

Feng Wang, Ming-Ming He, Zi-**an Wang, Su Li, Ying **, Chao Ren, Si-Mei Shi… in BMC Cancer (2019)

Article

Efficacy and safety of YinQiSanHuang-antiviral decoction in chronic hepatitis B: study protocol for a randomized, placebo-controlled, double-blinded trial

Chronic hepatitis B (CHB) is a global public health problem. Antiviral therapy is the primary treatment. Studies have shown that a combined therapy of traditional Chinese medicine (TCM) and conventional antivi...

Qing-Juan Wu, Wen-Liang Lv, Juan-Mei Li, Ting-Ting Zhang, Wen-hui Zhou… in Trials (2020)

Article

PRISMA extension for moxibustion 2020: recommendations, explanation, and elaboration

Moxibustion is a common intervention of Chinese medicine (CM). Systematic reviews (SRs) on moxibustion are increasing. Although the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) s...

Xuan Zhang, Ran Tan, Wai Ching Lam, Chung Wah Cheng, Liang Yao… in Systematic Reviews (2020)

Article

Radiotherapy plays an important role in improving the survival outcome in patients with T1–2N1M0 breast cancer – a joint analysis of 4262 real world cases from two institutions

To compare the survival outcomes between breast-conserving surgery (BCS) and modified radical mastectomy (MRM), and to investigate the role of radiotherapy (RT) in patients with pT1–2N1M0 breast cancer.

Guang-Yi Sun, Ge Wen, Yu-**g Zhang, Yu Tang, Hao **g, Jian-Yang Wang… in BMC Cancer (2020)

Article

Stereotactic EEG-guided radiofrequency thermocoagulation versus anterior temporal lobectomy for mesial temporal lobe epilepsy with hippocampal sclerosis: study protocol for a randomised controlled trial

In this report, we aim to describe the design for the randomised controlled trial of Stereotactic electroencephalogram (EEG)-guided Radiofrequency Thermocoagulation versus Anterior Temporal Lobectomy for Mesia...

Yi-He Wang, Si-Chang Chen, Peng-Hu Wei, Kun Yang, **ao-Tong Fan, Fei Meng… in Trials (2021)

Article

YinQiSanHuang Jiedu decoction for the treatment of hepatitis B-related compensated liver cirrhosis: study protocol for a multi-center randomized controlled trial

Hepatitis B-related compensated liver cirrhosis is related to a higher risk of hepatocellular carcinoma, and antiviral therapy is the preferred method. As the pathological mechanisms of liver fibrosis are comp...

Qing-Juan Wu, Wen-Liang Lv, Juan-Mei Li, Ting-Ting Zhang, Wen-Hui Zhou… in Trials (2021)

Article

Effects of immunoglobulin plus prednisolone in reducing coronary artery lesions in patients with Kawasaki disease: study protocol for a phase III multicenter, open-label, blinded-endpoints randomized controlled trial

Kawasaki disease (KD) is an acute systemic vasculitis of unclear etiology that mainly affects infants and young children. Strategies to reduce the incidence and severity of coronary artery lesions (CALs), the ...

Si-Yuan Lin, Lan He, Li-** **e, Yin Wang, Yi-**ang Lin, Yin-Yin Cao, Wei-Li Yan… in Trials (2021)

Article

Oral Huzhang granules for the treatment of acute gouty arthritis: protocol for a double-blind, randomized, controlled trial

Acute gouty arthritis (GA) is the main clinical manifestation and the most common initial symptom of gout. The treatment of acute GA involves the use of colchicine, non-steroidal anti-inflammatory drugs, and c...

Mi Zhou, Liang Hua, Yi-Fei Wang, Si-Ting Chen, Chun-mei Yang, Ming Zhang, **n Li… in Trials (2022)