25 Result(s)

Article

Prognostic significance of platelet‑to‑albumin ratio in patients with nasopharyngeal carcinoma receiving concurrent chemoradiotherapy: a retrospective study of 858 cases

Despite evidence supporting the high correlation of the novel platelet-to-albumin ratio (PAR) with survival in diverse malignancies, its prognostic relevance in nasopharyngeal carcinoma (NPC) remains underexpl...

**n Hua, Fei Xu, Wei Shi, Zhi-Qing Long, **n Huang, Fang-Fang Duan… in BMC Cancer (2024)

Article

Dynamic genomic changes in methotrexate-resistant human cancer cell lines beyond DHFR amplification suggest potential new targets for preventing drug resistance

Although DHFR gene amplification has long been known as a major mechanism for methotrexate (MTX) resistance in cancer, the early changes and detailed development of the resistance are not yet fully understood.

**ang-Ning Meng, **-Fa Ma, Yang-He Liu, Si-Qing Li, Xu Wang… in British Journal of Cancer (2024)

Article

Treatment for locally resectable stage IIIC1r cervical cancer: surgery or chemoradiotherapy?

The aim of this study was to compare the therapeutic value and treatment-related complications of radical hysterectomy with those of concurrent chemoradiotherapy (CCRT) for locally resectable (T1a2–T2a1) stage...

Mei-ling Zhong, Yin-chuan Liu, Jian-tong Yang, Ya-nan Wang, Mei-hong Ao… in BMC Cancer (2024)

Article

“Moderate” adjuvant chemotherapy-induced leukopenia is beneficial for survival of patients with early breast cancer: a retrospective study

The association between chemotherapy-induced leukopenia (CIL) and survival for patients with early breast cancer (EBC) is not known. We investigated the relationship between different grades of CIL and surviva...

Li Wang, Chang Jiang, Na Wang, Yan-Ling Wen, Si-Fen Wang, Cong Xue, **-Wen Bi… in BMC Cancer (2023)

Article

Prognostic implications of alpha-fetoprotein and C-reactive protein elevation in hepatocellular carcinoma following resection (PACE): a large cohort study of 2770 patients

Routine clinical staging for hepatocellular carcinoma (HCC) incorporates liver function, general health, and tumor morphology. Further refinement of prognostic assessments and treatment decisions may benefit f...

Kong-Ying Lin, Qing-**g Chen, Shi-Chuan Tang, Zhi-Wen Lin, Jian-** Zhang… in BMC Cancer (2023)

Article

A model based on adipose and muscle-related indicators evaluated by CT images for predicting microvascular invasion in HCC patients

The presence of microvascular invasion (MVI) will impair the surgical outcome of hepatocellular carcinoma (HCC). Adipose and muscle tissues have been confirmed to be associated with the prognosis of HCC. We ai...

**n-Cheng Mao, Shuo Shi, Lun-Jie Yan, Han-Chao Wang, Zi-Niu Ding… in Biomarker Research (2023)

Article

Predicting the outcomes of hepatocellular carcinoma downstaging with the use of clinical and radiomics features

Downstaging of hepatocellular carcinoma (HCC) makes it possible for patients beyond the criteria to have the chance of liver transplantation (LT) and improved outcomes. Thus, a procedure to predict the prognos...

Si-Yuan Wang, Kai Sun, Shuo **, Kai-Yu Wang, Nan Jiang, Si-Qiao Shan… in BMC Cancer (2023)

Article

The effects of the prognostic biomarker SAAL1 on cancer growth and its association with the immune microenvironment in lung adenocarcinoma

Inhibition of Serum Amyloid A-like 1 (SAAL1) expression could inhibit cancer progression and improve the prognosis of cancer patients. At present, the correlation between SAAL1 and lung adenocarcinoma (LAC) re...

Song Tong, Ni Jiang, Jun-Hao Wan, Chong-Rui Chen, Si-Hua Wang, Chuang-Yan Wu… in BMC Cancer (2023)

Article

Co-enrichment of CD8-positive T cells and macrophages is associated with clinical benefit of tislelizumab in solid tumors

Activated immune cells (IC) in the tumor microenvironment (TME) are critical for anti-tumor efficacy. Greater understanding of the dynamic diversity and crosstalk between IC is needed to clarify their associat...

Dingwei Ye, Jayesh Desai, **gwen Shi, Si-Yang Maggie Liu, Wei Shen… in Biomarker Research (2023)

Article

Inhibition of phosphorylated calcium/calmodulin-dependent protein kinase IIα relieves streptozotocin-induced diabetic neuropathic pain through regulation of P2X3 receptor in dorsal root ganglia

Diabetic neuropathic pain (DNP) is frequent among patients with diabetes. We previously showed that P2X3 upregulation in dorsal root ganglia (DRG) plays a role in streptozotocin (STZ)-induced DNP but the under...

**ao-fen He, Yu-rong Kang, Xue-yu Fei, Lu-hang Chen, **ang Li… in Purinergic Signalling (2023)

Article

Risk stratification and prognostic value of multi-modal MRI-based radiomics for extranodal nasal-type NK/T-cell lymphoma

Magnetic resonance imaging (MRI) performs well in the locoregional assessment of extranodal nasal-type NK/T-cell lymphoma (ENKTCL). It’s important to assess the value of multi-modal MRI-based radiomics for est...

Yu-Ting Zhao, Si-Ye Chen, **n Liu, Yong Yang, Bo Chen, Yong-Wen Song… in BMC Cancer (2023)

Article

CT Scans and Cancer Risks: A Systematic Review and Dose-response Meta-analysis

There is still uncertainty on whether ionizing radiation from CT scans can increase the risks of cancer. This study aimed to identify the association of cumulative ionizing radiation from CT scans with pertain...

Chun-Feng Cao, Kun-Long Ma, Hua Shan, Tang-Fen Liu, Si-Qiao Zhao, Yi Wan… in BMC Cancer (2022)

Article

Prognostic significance of prognostic nutritional index and systemic immune‐inflammation index in patients after curative breast cancer resection: a retrospective cohort study

Nutritional status and inflammation are closely associated with poor outcome in malignant tumors. However, the prognostic impact of postoperative in these variables on breast cancer (BC) remains inconclusive. ...

Tai Xu, Si-Ming Zhang, He-Ming Wu, **ao-Min Wen, Dong-Qin Qiu, Yu-Yang Yang… in BMC Cancer (2022)

Article

Correction: A novel tool for predicting the risk of central lymph node metastasis in patients with papillary thyroid microcarcinoma: a retrospective cohort study

Qian-wen Luo, Shan Gao, **ao Lv, Si-jia Li, Bo-fang Wang, Qing-qing Han… in BMC Cancer (2022)

Article

A novel tool for predicting the risk of central lymph node metastasis in patients with papillary thyroid microcarcinoma: a retrospective cohort study

Central lymph node status in papillary thyroid microcarcinoma (PTMC) plays an important role in treatment decision-making clinically, however, it is not easy to predict central lymph node metastasis (CLNM). Th...

Qian-wen Luo, Shan Gao, **ao Lv, Si-jia Li, Bo-fang Wang, Qing-qing Han… in BMC Cancer (2022)

Article

KSR2-14–3-3ζ complex serves as a biomarker and potential therapeutic target in sorafenib-resistant hepatocellular carcinoma

Kinase suppressor of Ras 2 (KSR2) is a regulator of MAPK signaling that is overactivated in most hepatocellular carcinoma (HCC). We sought to determine the role of KSR2 in HCC pathogenesis.

Chao Gao, Si-wei Wang, Jia-cheng Lu, **ao-qiang Chai, Yuan-cheng Li… in Biomarker Research (2022)

Article

Radiotherapy plays an important role in improving the survival outcome in patients with T1–2N1M0 breast cancer – a joint analysis of 4262 real world cases from two institutions

To compare the survival outcomes between breast-conserving surgery (BCS) and modified radical mastectomy (MRM), and to investigate the role of radiotherapy (RT) in patients with pT1–2N1M0 breast cancer.

Guang-Yi Sun, Ge Wen, Yu-**g Zhang, Yu Tang, Hao **g, Jian-Yang Wang… in BMC Cancer (2020)

Article

Phase I study of high-dose ascorbic acid with mFOLFOX6 or FOLFIRI in patients with metastatic colorectal cancer or gastric cancer

Preclinical studies suggest synergistic effectiveness of ascorbic acid (AA, vitamin C) and cytotoxic agents in gastrointestinal malignancies. This phase 1 study aimed to establish the maximum tolerated dose (M...

Feng Wang, Ming-Ming He, Zi-**an Wang, Su Li, Ying **, Chao Ren, Si-Mei Shi… in BMC Cancer (2019)

Article

Prognostic value of neutrophil-to-lymphocyte ratio in advanced nasopharyngeal carcinoma: a large institution-based cohort study from an endemic area

Findings remain unclear whether neutrophil-to-lymphocyte ratio (NLR) detrimentally affects advanced nasopharyngeal carcinoma (NPC) prognosis. We aim to evaluate the prognostic value of NLR in patients with NPC...

Ji-** Yao, Feng-Ting Zhu, Jun Dong, Zi-Bin Liang, Le-Wei Yang, Shao-Yi Chen… in BMC Cancer (2019)

Article

The detrimental effects of radiotherapy interruption on local control after concurrent chemoradiotherapy for advanced T-stage nasopharyngeal carcinoma: an observational, prospective analysis

Previous studies have reported radiotherapy interruption (RTI) is associated with poor local control in two-dimensional radiotherapy (2DRT) era. However, it remains unclear whether RTI still affects local cont...

Ji-** Yao, Ya-Nan **, Si-Yang Wang, Fan Zhang, Guan-Qun Zhou… in BMC Cancer (2018)