48 Result(s)

Article

Investigation of Metabolic and Inflammatory Disorder in the Aging FGF21 Knockout Mouse

Aging is a physiological condition accomplished with persistent low-grade inflammation and metabolic disorders. FGF21 has been reported to act as a potent longevity determinant, involving inflammatory response...

Lu-Qiong Cai, **u-Chun Li, Yang-Yue Wang, Yu-**n Chen, **a-Yan Zhu… in Inflammation (2024)

Article

Metformin normalizes mitochondrial function to delay astrocyte senescence in a mouse model of Parkinson’s disease through Mfn2-cGAS signaling

Senescent astrocytes play crucial roles in age-associated neurodegenerative diseases, including Parkinson’s disease (PD). Metformin, a drug widely used for treating diabetes, exerts longevity effects and neuro...

Min Wang, Tian Tian, Hong Zhou, Si-Yuan Jiang… in Journal of Neuroinflammation (2024)

Article

Autophagy dysfunction contributes to NLRP1 inflammasome-linked depressive-like behaviors in mice

Major depressive disorder (MDD) is a common but severe psychiatric illness characterized by depressive mood and diminished interest. Both nucleotide-binding oligomerization domain, leucine-rich repeat and pyri...

Ya-**g Zhu, **g Huang, Ru Chen, Yu Zhang, **n He… in Journal of Neuroinflammation (2024)

Article

GPR84 regulates pulmonary inflammation by modulating neutrophil functions

Acute lung injury (ALI) is an acute, progressive hypoxic respiratory failure that could develop into acute respiratory distress syndrome (ARDS) with very high mortality rate. ALI is believed to be caused by un...

Si-wei Wang, Qing Zhang, Dan Lu, You-chen Fang, **ao-ci Yan… in Acta Pharmacologica Sinica (2023)

Article

Astrocyte-derived SerpinA3N promotes neuroinflammation and epileptic seizures by activating the NF-κB signaling pathway in mice with temporal lobe epilepsy

Impaired activation and regulation of the extinction of inflammatory cells and molecules in injured neuronal tissues are key factors in the development of epilepsy. SerpinA3N is mainly associated with the acut...

Chong Liu, Xue-Min Zhao, Qiao Wang, Ting-Ting Du… in Journal of Neuroinflammation (2023)

Article

A Cohort Study on Deficiency of ADA2 from China

Deficiency of adenosine deaminase 2 (DADA2), an autosomal recessive autoinflammatory disorder caused by biallelic loss-of-function variants in adenosine deaminase 2 (ADA2), has not been systemically investigat...

Guo-min Li, Xu Han, Ye Wu, Wei Wang, Hong-xia Tang… in Journal of Clinical Immunology (2023)

Article

GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages

The putative medium-chain free fatty acid receptor GPR84 is a G protein-coupled receptor primarily expressed in myeloid cells that constitute the innate immune system, including neutrophils, monocytes, and mac...

Qing Zhang, Lin-hai Chen, Hui Yang, You-chen Fang… in Acta Pharmacologica Sinica (2022)

Article

Super-enhancer profiling identifies novel critical and targetable cancer survival gene LYL1 in pediatric acute myeloid leukemia

Acute myeloid leukemia (AML) is a myeloid neoplasm makes up 7.6% of hematopoietic malignancies. Super-enhancers (SEs) represent a special group of enhancers, which have been reported in multiple cell types. In...

Fang Fang, Jun Lu, Xu Sang, Yan-Fang Tao… in Journal of Experimental & Clinical Cancer … (2022)

Article

Autophagy-based unconventional secretion of HMGB1 in glioblastoma promotes chemosensitivity to temozolomide through macrophage M1-like polarization

Glioblastoma (GB) is the most common and highly malignant brain tumor characterized by aggressive growth and resistance to alkylating chemotherapy. Autophagy induction is one of the hallmark effects of anti-GB...

Zhuang Li, Wen-Juan Fu, **ao-Qing Chen… in Journal of Experimental & Clinical Cancer … (2022)

Article

A global phosphoproteomics analysis of adult Fasciola gigantica by LC–MS/MS

Protein phosphorylation plays key roles in a variety of essential cellular processes. Fasciola gigantica is a tropical liver fluke causing hepatobiliary disease fascioliasis, leading to human health threats and h...

Ming Pan, Shao-Yuan Bai, **g-Zhi Gong, Dan-Dan Liu, Feng Lu… in Parasitology Research (2022)

Article

Mitochondrial proteome of mouse oocytes and cisplatin-induced shifts in protein profile

Mitochondria are essential organelles that provide energy for mammalian cells and participate in multiple functions, such as signal transduction, cellular differentiation, and regulation of apoptosis. Compared...

Na Zhang, An-di Sun, Si-man Sun, Rui Yang, Yan-yan Shi… in Acta Pharmacologica Sinica (2021)

Article

circHMGCS1–016 reshapes immune environment by sponging miR-1236-3p to regulate CD73 and GAL-8 expression in intrahepatic cholangiocarcinoma

Accumulating evidence indicates that circRNAs may serve as essential regulators in the progression of several human cancers, but the function and mechanism of circRNAs in intrahepatic cholangiocarcinoma (ICC) ...

Ya-** Xu, Ze-Ning Dong, Si-Wei Wang… in Journal of Experimental & Clinical Cancer … (2021)

Article

A positive feedback loop between Periostin and TGFβ1 induces and maintains the stemness of hepatocellular carcinoma cells via AP-2α activation

Liver cancer stem cells (LCSCs) play key roles in the metastasis, recurrence, and chemotherapeutic resistance of hepatocellular carcinoma (HCC). Our previous research showed that the POSTN gene is closely related...

Gang Chen, Yi Wang, **n Zhao, **ao-zai **e… in Journal of Experimental & Clinical Cancer … (2021)

Article

The challenges and opportunities of traditional Chinese medicines against COVID-19: a way out from a network perspective

Hua-li Zuo, Yang-Chi-Dung Lin, Hsi-Yuan Huang, Xu Wang… in Acta Pharmacologica Sinica (2021)

Article

Splicing factor SRSF1 promotes breast cancer progression via oncogenic splice switching of PTPMT1

Intensive evidence has highlighted the effect of aberrant alternative splicing (AS) events on cancer progression when triggered by dysregulation of the SR protein family. Nonetheless, the underlying mechanism ...

Jun-**an Du, Yi-Hong Luo, Si-Jia Zhang… in Journal of Experimental & Clinical Cancer … (2021)

Article

Single-cell landscape of immunological responses in patients with COVID-19

In coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the relationship between disease severity and the host immune response is not fully und...

Ji-Yuan Zhang, **ang-Ming Wang, Xudong **ng, Zhe Xu, Chao Zhang… in Nature Immunology (2020)

Article

An immunopathogenic perspective of interleukin-1 signaling

**nwen Lin, Trix Twelkmeyer, Si-Yu Wang, Ruo-Nan Xu… in Cellular & Molecular Immunology (2020)

Article

A1 astrocytes contribute to murine depression-like behavior and cognitive dysfunction, which can be alleviated by IL-10 or fluorocitrate treatment

Astrocytes are crucial regulators in the central nervous system. Abnormal activation of astrocytes contributes to some behavior deficits. However, mechanisms underlying the effects remain unclear. Here, we stu...

He-Yang Zhang, Yan Wang, Youdi He, Ting Wang… in Journal of Neuroinflammation (2020)

Article

Correction to: Promoter hypomethylation mediated upregulation of MicroRNA-10b-3p targets FOXO3 to promote the progression of esophageal squamous cell carcinoma (ESCC)

In the original publication of this manuscript [1], Fig. 6 contains a repeated image in error (the left image of ‘Migration’ and the left image of ‘Invasion’).

Yi-fang Lu, Jia-rui Yu, Zhao Yang… in Journal of Experimental & Clinical Cancer … (2020)

Article

Meningitic Escherichia coli-induced upregulation of PDGF-B and ICAM-1 aggravates blood-brain barrier disruption and neuroinflammatory response

Blood-brain barrier (BBB) disruption and neuroinflammation are considered key mechanisms of pathogenic Escherichia coli invasion of the brain. However, the specific molecules involved in meningitic E. coli-induce...

Rui-Cheng Yang, **n-Yi Qu, Si-Yu **ao, Liang Li, Bo-Jie Xu… in Journal of Neuroinflammation (2019)