29 Result(s)

Article

GPR84 regulates pulmonary inflammation by modulating neutrophil functions

Acute lung injury (ALI) is an acute, progressive hypoxic respiratory failure that could develop into acute respiratory distress syndrome (ARDS) with very high mortality rate. ALI is believed to be caused by un...

Si-wei Wang, Qing Zhang, Dan Lu, You-chen Fang, **ao-ci Yan… in Acta Pharmacologica Sinica (2023)

Article

GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages

The putative medium-chain free fatty acid receptor GPR84 is a G protein-coupled receptor primarily expressed in myeloid cells that constitute the innate immune system, including neutrophils, monocytes, and mac...

Qing Zhang, Lin-hai Chen, Hui Yang, You-chen Fang… in Acta Pharmacologica Sinica (2022)

Article

Mitochondrial proteome of mouse oocytes and cisplatin-induced shifts in protein profile

Mitochondria are essential organelles that provide energy for mammalian cells and participate in multiple functions, such as signal transduction, cellular differentiation, and regulation of apoptosis. Compared...

Na Zhang, An-di Sun, Si-man Sun, Rui Yang, Yan-yan Shi… in Acta Pharmacologica Sinica (2021)

Article

The challenges and opportunities of traditional Chinese medicines against COVID-19: a way out from a network perspective

Hua-li Zuo, Yang-Chi-Dung Lin, Hsi-Yuan Huang, Xu Wang… in Acta Pharmacologica Sinica (2021)

Article

Single-cell landscape of immunological responses in patients with COVID-19

In coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the relationship between disease severity and the host immune response is not fully und...

Ji-Yuan Zhang, **ang-Ming Wang, Xudong **ng, Zhe Xu, Chao Zhang… in Nature Immunology (2020)

Article

An immunopathogenic perspective of interleukin-1 signaling

**nwen Lin, Trix Twelkmeyer, Si-Yu Wang, Ruo-Nan Xu… in Cellular & Molecular Immunology (2020)

Article

Pharmacokinetic and metabolomic analyses of the neuroprotective effects of salvianolic acid A in a rat ischemic stroke model

Salvianolic acid A (SAA), a water-soluble phenolic acid isolated from the root of Dan Shen, displays distinct antioxidant activity and effectiveness in protection against cerebral ischemia/reperfusion (I/R) da...

Si-qi Feng, Nan Aa, Jian-liang Geng, **g-qiu Huang… in Acta Pharmacologica Sinica (2017)

Article

Dopamine D2 receptor antagonist sulpiride enhances dexamethasone responses in the treatment of drug-resistant and metastatic breast cancer

Recent evidence shows that dopamine D2-like receptor (D2DR) antagonists, such as trifluoperazine and thioridazine, are effective for cancer therapy and inhibition of cancer stem-like cells (CSCs). In this stud...

Jian Li, Qing-yu Yao, Jun-sheng Xue, Li-jie Wang, Yin Yuan… in Acta Pharmacologica Sinica (2017)

Article

C33(S), a novel PDE9A inhibitor, protects against rat cardiac hypertrophy through upregulating cGMP signaling

Phosphodiesterase-9A (PDE9A) expression is upregulated during cardiac hypertrophy and heart failure. Accumulating evidence suggests that PDE9A might be a promising therapeutic target for heart diseases. The pr...

Pan-xia Wang, Zhuo-ming Li, Si-dong Cai, **g-yan Li, ** He… in Acta Pharmacologica Sinica (2017)

Article

Sarsasapogenin-AA13 inhibits LPS-induced inflammatory responses in macrophage cells in vitro and relieves dimethylbenzene-induced ear edema in mice

Sarsasapogenin-AA13 (AA13) is a novel synthetic derivative of sarsasapogenin extracted from the Chinese herb Rhizoma Anemarrhenae. In this study we investigated the effects of AA13 on lipopolysaccharide (LPS)-...

Dong Dong, Nan-nan Zhou, Rui-xuan Liu, Jia-wei **ong, Hui Pan… in Acta Pharmacologica Sinica (2017)

Article

2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside protects murine hearts against ischemia/reperfusion injury by activating Notch1/Hes1 signaling and attenuating endoplasmic reticulum stress

2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG) is a water-soluble active component extracted from Polygonum multiflorum Thunb. A number of studies demonstrate that TSG exerts cardioprotective effects. Sinc...

Meng Zhang, Li-ming Yu, Hang Zhao, Xuan-xuan Zhou, Qian Yang… in Acta Pharmacologica Sinica (2017)

Article

In vitro assessment of the glucose-lowering effects of berberrubine-9-O-β-D-glucuronide, an active metabolite of berberrubine

Berberrubine (BRB) is the primary metabolite of berberine (BBR) that has shown a stronger glucose-lowering effect than BBR in vivo. On the other hand, BRB is quickly and extensively metabolized into berberrubine-...

Na Yang, Run-bin Sun, **ng-long Chen, Le Zhen, Chun Ge… in Acta Pharmacologica Sinica (2017)

Article

BX-795 inhibits HSV-1 and HSV-2 replication by blocking the JNK/p38 pathways without interfering with PDK1 activity in host cells

BX-795 is an inhibitor of 3-phosphoinositide-dependent kinase 1 (PDK1), but also a potent inhibitor of the IKK-related kinase, TANKbinding kinase 1 (TBK1) and IKKɛ. In this study we attempted to elucidate the ...

Ai-rong Su, Min Qiu, Yan-lei Li, Wen-tao Xu, Si-wei Song… in Acta Pharmacologica Sinica (2017)

Article

Discovery, synthesis, biological evaluation and structure-based optimization of novel piperidine derivatives as acetylcholine-binding protein ligands

The homomeric α7 nicotinic receptor (α7 nAChR) is widely expressed in the human brain that could be activated to suppress neuroinflammation, oxidative stress and neuropathic pain. Consequently, a number of α7 ...

Jian Shen, **-cheng Yang, Ming-cheng Yu, Li **ao… in Acta Pharmacologica Sinica (2017)

Article

Silibinin and indocyanine green-loaded nanoparticles inhibit the growth and metastasis of mammalian breast cancer cells in vitro

To improve the therapeutic efficacy of cancer treatments, combinational therapies based on nanosized drug delivery system (NDDS) has been developed recently. In this study we designed a new NDDS loaded with an...

Hui-** Sun, **g-han Su, Qing-shuo Meng, Qi Yin… in Acta Pharmacologica Sinica (2016)

Article

Activity- and development-dependent down-regulation of TARPγ8 and GluA1 in cultured rat hippocampal neurons

Transmembrane AMPA receptor regulatory proteins (TARPs) regulate the trafficking and expression of AMPA receptors that are essential for the fast excitatory synaptic transmission and plasticity in the brain. T...

Jian-gang Wang, Ya-li Wang, Fang Xu, **g-xi Zhao… in Acta Pharmacologica Sinica (2016)

Article

Intratumoral estrogen sulfotransferase induction contributes to the anti-breast cancer effects of the dithiocarbamate derivative TM208

Sulfotransferase-catalyzed sulfation is the most important pathway for inactivating estrogens. Thus, activation of estrogen sulfotransferase (EST) may be an alternative approach for the treatment of estrogen-d...

**-wei Ji, Guang-** Chen, Yan Song, Ming Hua, Li-jie Wang… in Acta Pharmacologica Sinica (2015)

Article

Sanguinarine inhibits Rac1b-rendered cell survival enhancement by promoting apoptosis and blocking proliferation

Small GTPase Rac1 is a member of the Ras superfamily, which plays important roles in regulation of cytoskeleton reorganization, cell growth, proliferation, migration, etc. The aim of this study was to determine h...

Li Ying, Gang Li, Si-si Wei, Hong Wang, Pei An, Xun Wang… in Acta Pharmacologica Sinica (2015)

Article

Dopamine D₁ receptor activation induces dehydroepiandrosterone sulfotransferase (SULT2A1) in HepG2 cells

Dopamine receptors are present in the nervous system and also widely distributed in the periphery. The aim of this study was to investigate the role of D₁ subtype dopamine receptors (DRD₁) in the regulation of de...

Jiao-jiao Xu, Si-yuan Wang, Ye Chen, Guang-** Chen… in Acta Pharmacologica Sinica (2014)

Article

Ginsenoside compound K suppresses the abnormal activation of T lymphocytes in mice with collagen-induced arthritis

To investigate the anti-arthritis and immunomodulatory activities of ginsenoside compound K (C-K) in mice with collagen-induced arthritis (CIA).

Kang-kang Liu, Qing-tong Wang, Si-min Yang, **g-yu Chen… in Acta Pharmacologica Sinica (2014)