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Article
Si**g Pan
Neurosciences
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Propofol Mitigates Sepsis-Induced Brain Injury by Inhibiting Ferroptosis Via Activation of the Nrf2/HO-1axis
Sepsis-associated encephalopathy (SAE) develops in 30–70% of hospitalized patients with sepsis. In intensive care units (ICUs), propofol is often administered to ensure an appropriate level of sedation in mech...
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CCL2 Potentiates Inflammation Pain and Related Anxiety-Like Behavior Through NMDA Signaling in Anterior Cingulate Cortex
Previous studies have shown that the C-C motif chemokine ligand 2 (CCL2) is widely expressed in the nervous system and involved in regulating the development of chronic pain and related anxiety-like behaviors,...
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Multimodal AI needs active human interaction
As AI tools quickly become more capable, multimodal and pervasive in daily life, it is important to actively collaborate with them in ways that promote — rather than inhibit — human skill development.
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Clinical features and underlying etiology of children with Lennox–Gastaut syndrome
Lennox–Gastaut Syndrome (LGS) is characterized by the presence of multiple seizure types and encompasses a heterogenous group of etiologies. The aim of our study was to evaluate the etiological profile of LGS ...
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Open AccessSpecific Mode Electroacupuncture Stimulation Mediates the Delivery of NGF Across the Hippocampus Blood–Brain Barrier Through p65-VEGFA-TJs to Improve the Cognitive Function of MCAO/R Convalescent Rats
Cognitive impairment frequently presents as a prevalent consequence following stroke, imposing significant burdens on patients, families, and society. The objective of this study was to assess the effectivenes...
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Open AccessNucleus Accumbens Corticotropin-Releasing Hormone Neurons Projecting to the Bed Nucleus of the Stria Terminalis Promote Wakefulness and Positive Affective State
The nucleus accumbens (NAc) plays an important role in various emotional and motivational behaviors that rely on heightened wakefulness. However, the neural mechanisms underlying the relationship between arous...
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Open AccessCriteria for stop** high-flow nasal oxygen for acute hypoxemic respiratory failure: a systematic review of randomized controlled trials
High-flow nasal cannula (HFNC) has been widely promoted during the COVID-19 pandemic to circumvent invasive mechanical ventilation. While there are several reported benefits, randomized trials demonstrate inco...
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Clinical and video-polysomnographic characterization of restless sleep disorder in adult patients
Adults with restless sleep disorder (RSD) have never been studied clinically and polysomnographically. This study aimed to describe the clinical manifestation, duration, and distribution of sleep-related movem...
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Potential Plausible Role of Stem Cell for Treating Depressive Disorder: a Retrospective Review
Depression poses a significant threat to global physical and mental health, impacting around 3.8% of the population with a rising incidence. Current treatment options primarily involve medication and psycholog...
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Ablated Sonic Hedgehog Signaling in the Dentate Gyrus of the Dorsal and Ventral Hippocampus Impairs Hippocampal-Dependent Memory Tasks and Emotion in a Rat Model of Depression
Specific memory processes and emotional aberrations in depression can be attributed to the different dorsal–ventral regions of the hippocampus. However, the molecular mechanisms underlying the differential fun...
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Gliclazide Ameliorates Neuronal Injury by Attenuating Oxidative Stress in D-gal-Induced Senescent Cells and Aging Mice
Enhancement of oxidative stress and resultant neuronal injury play important roles in initiating cognitive impairment during the aging process. Thus, attenuating oxidative injury is regarded as a profitable th...
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Open AccessC8-ceramide modulates microglia BDNF expression to alleviate postoperative cognition dysfunction via PKCδ/NF-κB signaling pathway
Postoperative cognitive dysfunction (POCD) is a kind of serious postoperative complication in surgery with general anesthesia and it may affect patients’ normal lives. Activated microglia are thought to be one...
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Targeted Therapy of Spinal Cord Injury: Inhibition of Apoptosis Is a Promising Therapeutic Strategy
Spinal cord injury (SCI) is a serious disabling central nervous system injury that can lead to motor, sensory, and autonomic dysfunction below the injury level. SCI can be divided into primary injury and secon...
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Open AccessMis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits
The key pathological signature of ALS/ FTLD is the mis-localization of endogenous TDP-43 from the nucleus to the cytoplasm. However, TDP-43 gain of function in the cytoplasm is still poorly understood since TD...
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Neurocognitive performance of badminton players at different competitive levels in visuospatial attention tasks
Visuospatial attention (VSA) is a cognitive function that enables athletes, particularly those engaged in open-skill sports, to allocate attentional resources efficiently to the appropriate target and in the a...
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Open AccessLifestyle and medical conditions in relation to ALS risk and progression—an introduction to the Swedish ALSrisc Study
This study was an introduction to the Swedish ALSrisc Study and explored the association of lifestyle and medical conditions, with risk and progression of amyotrophic lateral sclerosis (ALS).
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Open AccessMap** of spastic muscle activity after stroke: difference between passive stretch and active contraction
Investigating the spatial distribution of muscle activity would facilitate understanding the underlying mechanism of spasticity. The purpose of this study is to investigate the characteristics of spastic muscl...
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A working memory model based on recurrent neural networks using reinforcement learning
Numerous electrophysiological experiments have reported that the prefrontal cortex (PFC) is involved in the process of working memory. PFC neurons continue firing to maintain stimulus information in the delay ...
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Myasthenia gravis due to anti-PD-1 treatment for an advanced colon cancer patient: a case report and literature review
With the advancement of cancer treatment technologies, immunotherapy has begun to be widely utilized. Colon cancer is one of the most common types of cancer, with metastasis being a frequent occurrence in late...
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Kv3.1 Interaction with UBR5 Is Required for Chronic Inflammatory Pain
Chronic inflammatory pain caused by neuronal hyperactivity is a common and refractory disease. Kv3.1, a member of the Kv3 family of voltage-dependent K+ channels, is a major determinant of the ability of neurons ...
