411 Result(s)
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Article
Propofol Mitigates Sepsis-Induced Brain Injury by Inhibiting Ferroptosis Via Activation of the Nrf2/HO-1axis
Sepsis-associated encephalopathy (SAE) develops in 30–70% of hospitalized patients with sepsis. In intensive care units (ICUs), propofol is often administered to ensure an appropriate level of sedation in mech...
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Effects of Commonly used Surfactants, Poloxamer 188 and Tween 80, on the Drug Transport Capacity of Intestinal Glucose Transporters
Some glycoside drugs can be transported through intestinal glucose transporters (IGTs). The surfactants used in oral drug preparations can affect the function of transporter proteins. This study aimed to inves...
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Open AccessNeutralizing Antibody Sample Testing and Report Harmonization
Immunogenicity testing and characterization is an important part of understanding the immune response to administration of a protein therapeutic. Neutralizing antibody (NAb) assays are used to characterize a p...
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Article
E2F1 Facilitates the Proliferation and Stemness of Gastric Cancer Cells by Activating CDC25B Transcription and Modulating the MAPK Pathway
Gastric cancer (GC) is a health problem that concerns people around the world. CDC25B is an essential cell cycle regulatory factor that is overexpressed in a variety of tumor cells. CDC25B plays a vital part i...
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Article
A working memory model based on recurrent neural networks using reinforcement learning
Numerous electrophysiological experiments have reported that the prefrontal cortex (PFC) is involved in the process of working memory. PFC neurons continue firing to maintain stimulus information in the delay ...
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Discovering cholinesterase inhibitors from Chinese herbal medicine with deep learning models
Traditional Chinese medicine (TCM) holds distinctive advantages in the management of Alzheimer’s disease. Nonetheless, a considerable gap remains in our understanding of its pharmacologically active constituen...
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Increased FGL1 Expression Predicts Poor Prognosis and Promotes EMT in Head and Neck Squamous Cell Carcinoma
Fibrinogen-like protein 1 (FGL1) is a proliferation- and metabolism-related factor secreted by the liver that is aberrantly expressed and functionally abnormal in human malignancies. However, the role of FGL1 in ...
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Open AccessTemporal-spatial deciphering mental subtraction in the human brain
Mental subtraction, involving numerical processing and operation, requires a complex interplay among several brain regions. Diverse studies have utilized scalp electroencephalograph, electrocorticogram, or fun...
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Article
Effects of Three Kinds of Carbohydrate Pharmaceutical Excipients—Fructose, Lactose and Arabic Gum on Intestinal Absorption of Gastrodin through Glucose Transport Pathway in Rats
Some glucoside drugs can be transported via intestinal glucose transporters (IGTs), and the presence of carbohydrate excipients in pharmaceutical formulations may influence the absorption of them. This study, ...
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Article
5-Hydroxymethylfurfural Ameliorates Allergic Inflammation in HMC-1 Cells by Inactivating NF-κB and MAPK Signaling Pathways
Allergic inflammation is the foundation of multiple allergic disorders, such as allergic rhinitis and asthma. Mast cells are effector cells that initiate inflammatory response. 5-hydroxymethylfurfural (5-HMF),...
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Utilizing a novel model of PANoptosis-related genes for enhanced prognosis and immune status prediction in kidney renal clear cell carcinoma
Kidney renal clear cell carcinoma (KIRC) is the most common histopathologic type of renal cell carcinoma. PANoptosis, a cell death pathway that involves an interplay between pyroptosis, apoptosis and necroptos...
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Article
The Synergetic Effect of 3D Printing and Electrospinning Techniques in the Fabrication of Bone Scaffolds
The primary goal of bone tissue engineering is to restore and rejuvenate bone defects by using a suitable three-dimensional scaffold, appropriate cells, and growth hormones. Various scaffolding methods are use...
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Article
Machine to brain: facial expression recognition using brain machine generative adversarial networks
The human brain can effectively perform Facial Expression Recognition (FER) with a few samples by utilizing its cognitive ability. However, unlike the human brain, even the well-trained deep neural network is ...
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Article
Short-length SSVEP data extension by a novel generative adversarial networks based framework
Steady-state visual evoked potentials (SSVEPs) based brain–computer interface (BCI) has received considerable attention due to its high information transfer rate (ITR) and available quantity of targets. Howeve...
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Article
Open AccessmiRNA-383-5p Regulated Migration and Invasion of Tumor Cells by Inhibiting NCKAP1 Expression in Gastric Cancer
Gastric cancer (GC) is the second deadliest disease in Asia, so it is crucial to find its promising therapeutic targets. The expression profile data of miR383-5p in the Cancer Genome Atlas (TCGA) were analyzed...
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Article
FSP1-mediated ferroptosis in cancer: from mechanisms to therapeutic applications
Ferroptosis is a new discovered regulated cell death triggered by the ferrous ion (Fe2+)-dependent accumulation of lipid peroxides associated with cancer and many other diseases. The mechanism of ferroptosis incl...
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The role of extracellular glutamate homeostasis dysregulated by astrocyte in epileptic discharges: a model evidence
Glutamate (Glu) is a predominant excitatory neurotransmitter that acts on glutamate receptors to transfer signals in the central nervous system. Abnormally elevated extracellular glutamate levels is closely re...
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Investigation of GPR143 as a promising novel marker for the progression of skin cutaneous melanoma through bioinformatic analyses and cell experiments
Skin cutaneous melanoma (SKCM) is an aggressive and life-threatening skin cancer. G-protein coupled receptor 143 (GPR143) belongs to the superfamily of G protein-coupled receptors.
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Therapeutic efficacy and pharmacological mechanism of Yindan **nnaotong soft capsule on acute ischemic stroke: a meta-analysis and network pharmacology analysis
Yindan **nnaotong soft capsule (YDXNT), a traditional Chinese medicine preparation, has shown a promising effect in the treatment of acute ischemic stroke (AIS). The goal of this study was to investigate the t...
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Article
A Halloysite Nanotubes-based Probe for Efficient Fluorescence Detection and Adsorption Removal of Pb2+ in Water
The detection and removal of Pb2+ is of utmost importance for environmental protection and human health due to its toxicity, persistent pollution, and bioaccumulation effects. To address the limitations associate...
