11 Result(s)

Article

Longitudinal multi-omics study of palbociclib resistance in HR-positive/HER2-negative metastatic breast cancer

Cyclin-dependent kinase 4/6 inhibitor (CDK4/6) therapy plus endocrine therapy (ET) is an effective treatment for patients with hormone receptor-positive/human epidermal receptor 2-negative metastatic breast ca...

Yeon Hee Park, Seock-Ah Im, Kyunghee Park, Ji Wen, Kyung-Hun Lee… in Genome Medicine (2023)

Article

A rare variant analysis framework using public genotype summary counts to prioritize disease-predisposition genes

Sequencing cases without matched healthy controls hinders prioritization of germline disease-predisposition genes. To circumvent this problem, genotype summary counts from public data sets can serve as control...

Wenan Chen, Shuoguo Wang, Saima Sultana Tithi, David W. Ellison… in Nature Communications (2022)

Article

Chemotherapy induces dynamic immune responses in breast cancers that impact treatment outcome

To elucidate the effects of neoadjuvant chemotherapy (NAC), we conduct whole transcriptome profiling coupled with histopathology analyses of a longitudinal breast cancer cohort of 146 patients including 110 pa...

Yeon Hee Park, Samir Lal, Jeong Eon Lee, Yoon-La Choi, Ji Wen… in Nature Communications (2020)

Article

Structure and evolution of double minutes in diagnosis and relapse brain tumors

Double minute chromosomes are extrachromosomal circular DNA fragments frequently found in brain tumors. To understand their evolution, we characterized the double minutes in paired diagnosis and relapse tumors...

Ke Xu, Liang Ding, Ti-Cheng Chang, Ying Shao, Jason Chiang… in Acta Neuropathologica (2019)

Article

The genomic landscape of pediatric myelodysplastic syndromes

Myelodysplastic syndromes (MDS) are uncommon in children and have a poor prognosis. In contrast to adult MDS, little is known about the genomic landscape of pediatric MDS. Here, we describe the somatic and ger...

Jason R. Schwartz, **g Ma, Tamara Lamprecht, Michael Walsh… in Nature Communications (2017)

Article

Extremely low-coverage whole genome sequencing in South Asians captures population genomics information

The cost of Whole Genome Sequencing (WGS) has decreased tremendously in recent years due to advances in next-generation sequencing technologies. Nevertheless, the cost of carrying out large-scale cohort studie...

Navin Rustagi, Anbo Zhou, W. Scott Watkins, Erika Gedvilaite, Shuoguo Wang… in BMC Genomics (2017)

Article

A comprehensive analysis of piRNAs from adult human testis and their relationship with genes and mobile elements

Piwi-interacting RNAs (piRNAs) are a recently discovered class of small non-coding RNAs whose best-understood function is to repress mobile element (ME) activity in animal germline. To date, nearly all piRNA s...

Hongseok Ha, Jimin Song, Shuoguo Wang, Aurélie Kapusta, Cédric Feschotte… in BMC Genomics (2014)

Article

Phase locking and resetting in human subthalamic neurons

Shuoguo Wang, Ted Weyand, Erich Richter, Carmen C Canavier in BMC Neuroscience (2011)

Article

PRC skewness determines synchronization properties of pulse coupled circuits with delay

Shuoguo Wang, Lakshmi Chandrasekaran, Fernando Fernandez, John White… in BMC Neuroscience (2010)