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Open AccessGenetic and phenotypic analysis of 225 Chinese children with developmental delay and/or intellectual disability using whole-exome sequencing
Developmental delay (DD), or intellectual disability (ID) is a very large group of early onset disorders that affects 1–2% of children worldwide, which have diverse genetic causes that should be identified. Ge...
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Article
Open AccessAnnoPRO: a strategy for protein function annotation based on multi-scale protein representation and a hybrid deep learning of dual-path encoding
Protein function annotation has been one of the longstanding issues in biological sciences, and various computational methods have been developed. However, the existing methods suffer from a serious long-tail ...
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Article
SmTIR1 positively regulates the growth and root development of Salvia miltiorrhiza
The roots of Salvia miltiorrhiza are widely used as medicinal materials in China and other East Asian countries. Root morphology and development significantly influence both the quality and yield of this herb. Ho...
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Open AccessGenetic diversity and signatures of selection in BoHuai goat revealed by whole-genome sequencing
Cross breeding is an important way to improve livestock performance. As an important livestock and poultry resource in Henan Province of China, Bohuai goat was formed by crossing Boer goat and Huai goat. After...
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Open AccessAssessing genomic diversity and signatures of selection in Pinan cattle using whole-genome sequencing data
Crossbreeding is an important way to improve production beef cattle performance. Pinan cattle is a new hybrid cattle obtained from crossing Piedmontese bulls with Nanyang cows. After more than 30 years of cros...
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Open AccessTranscriptome-wide study revealed m6A regulation of embryonic muscle development in Dingan goose (Anser cygnoides orientalis)
The number of myofiber is determined during the embryonic stage and does not increase during the postnatal period for birds, including goose. Thus, muscle production of adult goose is pre-determined during emb...
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Open AccessAssessing genomic diversity and signatures of selection in Jiaxian Red cattle using whole-genome sequencing data
Native cattle breeds are an important source of genetic variation because they might carry alleles that enable them to adapt to local environment and tough feeding conditions. Jiaxian Red, a Chinese native cat...
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Article
Primer development and functional classification of EST-SSR markers in Ulmus species
At present, the available SSR markers of elm (Ulmus) have been seriously deficient, which can not meet the needs of molecular marker-assisted breeding and evaluation of germplasm resources. In this study, transcr...
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Transcriptome-sequencing analyses reveal putative genes related to flower color variation in Chinese Rosa rugosa
Rosa rugosa is an excellent landsca** plant famous for its fragrance and primarily red flower. In this study, transcriptome sequencing on R. rugosa ‘Red Zizhi’ and its bud mutations R. rugosa ‘Pink Zizhi’ and R...
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Article
Instability in mitochondrial membranes in Polima cytoplasmic male sterility of Brassica rapa ssp. chinensis
Cytoplasmic male sterility (CMS) is an important factor to observe heterosis in Brassica rapa. Although several studies have documented the rearrangements of mitochondrial DNA and dysfunction in the mitochondria ...
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Effect and mechanism of endophytic bacteria on growth and secondary metabolite synthesis in Salvia miltiorrhiza hairy roots
Our study found that except Novosphingobium resinovorum (B5) Salvia miltiorrhiza root endophytic bacteria Pseudomonas brassicacearum sub sp. neoaurantiaca (B1), Rhizobium radiobacter (B2), Pseudomonas thivervalen...
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Article
Abundance, marker development and genetic map** of microsatellites from unigenes in Brassica napus
Rapeseed (Brassica napus) is the second most important oil crop in the world after soybean. The repertoire of simple sequence repeat (SSR) markers for rapeseed is limited and warrants a search for a larger number...
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Development and genetic map** of microsatellite markers from whole genome shotgun sequences in Brassica oleracea
The availability of whole genome shotgun sequences (WGSs) in Brassica oleracea provides an unprecedented opportunity for development of microsatellite or simple sequence repeat (SSR) markers for genome analysis a...
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Open AccessConstruction of an integrated genetic linkage map for the A genome of Brassica napus using SSR markers derived from sequenced BACs in B. rapa
The Multinational Brassica rapa Genome Sequencing Project (BrGSP) has developed valuable genomic resources, including BAC libraries, BAC-end sequences, genetic and physical maps, and seed BAC sequences for Brassi...
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Development and genetic map** of microsatellite markers from genome survey sequences in Brassica napus
Microsatellite or simple sequence repeat (SSR) markers are routinely used for tagging genes and assessing genetic diversity. In spite of their importance, there are limited numbers of SSR markers available for Br...
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The t-mixture model approach for detecting differentially expressed genes in microarrays
The finite mixture model approach has attracted much attention in analyzing microarray data due to its robustness to the excessive variability which is common in the microarray data. Pan (2003) proposed to use th...