67 Result(s)
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Article
Shun** Zhang
Life Sciences
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Genome-wide identification of the SAUR gene family and screening for SmSAURs involved in root development in Salvia miltiorrhiza
SmSAUR4, SmSAUR18, SmSAUR28, SmSAUR37, and SmSAUR38 were probably involved in the auxin-mediated root development in Salvia miltiorrhiza.
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Author Correction: Adenine transversion editors enable precise, efficient A•T-to-C•G base editing in mammalian cells and embryos
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Author Correction: Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing
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Open AccessThe role of mitochondrial dynamics and mitophagy in skeletal muscle atrophy: from molecular mechanisms to therapeutic insights
Skeletal muscle is the largest metabolic organ of the human body. Maintaining the best quality control and functional integrity of mitochondria is essential for the health of skeletal muscle. However, mitochon...
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Open AccessGenetic and phenotypic analysis of 225 Chinese children with developmental delay and/or intellectual disability using whole-exome sequencing
Developmental delay (DD), or intellectual disability (ID) is a very large group of early onset disorders that affects 1–2% of children worldwide, which have diverse genetic causes that should be identified. Ge...
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Adenine transversion editors enable precise, efficient A•T-to-C•G base editing in mammalian cells and embryos
Base editors have substantial promise in basic research and as therapeutic agents for the correction of pathogenic mutations. The development of adenine transversion editors has posed a particular challenge. H...
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Open AccessAnnoPRO: a strategy for protein function annotation based on multi-scale protein representation and a hybrid deep learning of dual-path encoding
Protein function annotation has been one of the longstanding issues in biological sciences, and various computational methods have been developed. However, the existing methods suffer from a serious long-tail ...
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Open AccessClinical Indicators of Hepatotoxicity in Newly Diagnosed Acute Promyelocytic Leukemia Patients Undergoing Arsenic Trioxide Treatment
Arsenic trioxide (ATO)-induced hepatotoxicity is often observed in acute promyelocytic leukemia (APL) patients and decreases therapeutic effect of ATO. Thus, concerns over hepatotoxicity have been raised. The ...
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SmTIR1 positively regulates the growth and root development of Salvia miltiorrhiza
The roots of Salvia miltiorrhiza are widely used as medicinal materials in China and other East Asian countries. Root morphology and development significantly influence both the quality and yield of this herb. Ho...
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Open AccessPyrroloquinoline quinone inhibits PCSK9-NLRP3 mediated pyroptosis of Leydig cells in obese mice
Abnormal lipid metabolism and chronic low-grade inflammation are the main traits of obesity. Especially, the molecular mechanism of concomitant deficiency in steroidogenesis-associated enzymes related to testo...
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Open AccessHnrnpk is essential for embryonic limb bud development as a transcription activator and a collaborator of insulator protein Ctcf
Proper development of the limb bud relies on the concordance of various signals, but its molecular mechanisms have not yet been fully illustrated. Here we report that heterogeneous nuclear ribonucleoprotein K ...
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Open AccessCDC42-mediated Wnt signaling facilitates odontogenic differentiation of DPCs during tooth root elongation
CDC42 is a member of Rho GTPase family, acting as a molecular switch to regulate cytoskeleton organization and junction maturation of epithelium in organ development. Tooth root pattern is a highly complicated...
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Open AccessEnzymatic fermentation of rapeseed cake significantly improved the soil environment of tea rhizosphere
Rapeseed cake is an important agricultural waste. After enzymatic fermentation, rapeseed cake not only has specific microbial diversity but also contains a lot of fatty acids, organic acids, amino acids and th...
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Hypervirulent Klebsiella pneumoniae detection methods: a minireview
Hypervirulent Klebsiella pneumoniae (hvKp), characterized by high virulence and epidemic potential, has become a global public health challenge. Therefore, improving the identification of hvKp and enabling earlie...
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Comparative transcriptome analysis reveals the regulatory effects of exogenous auxin on lateral root development and tanshinone accumulation in Salvia miltiorrhiza
The physiological and transcriptome analysis revealed that auxin was a positive regulator of lateral root development and tanshinone accumulation in Salvia miltiorrhiza ...
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Open AccessMultiomics strategies for decoding seed dormancy breakdown in Paris polyphylla
The disruption of seed dormancy is a complicated process and is controlled by various factors. Among these factors, membrane lipids and plant hormones are two of the most important ones. Paris polyphylla is an im...
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Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing
Cytosine base editors (CBEs) efficiently generate precise C·G-to-T·A base conversions, but the activation-induced cytidine deaminase/apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (AID/APOBEC)...
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Open AccessGenetic diversity and signatures of selection in BoHuai goat revealed by whole-genome sequencing
Cross breeding is an important way to improve livestock performance. As an important livestock and poultry resource in Henan Province of China, Bohuai goat was formed by crossing Boer goat and Huai goat. After...
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Effects of acute low-salinity stress on osmoregulation, antioxidant capacity, and growth of the black sea bream (Acanthopagrus schlegelii)
The black sea bream (Acanthopagrus schlegelii) is an important marine economic fish found on the southeast coast of China. Because of the frequent climate change, the salinity of the waters inhabited by A. schleg...
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Rice genotype affects nitrification inhibition in the rhizosphere
Biological nitrification inhibitors (BNIs) can play an important role in inhibiting nitrification and enhancing nitrogen use efficiency (NUE) in agriculture. However, most current BNI studies have been conduct...
