11 Result(s)
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Article
Open AccessMesenchymal stromal cell biotherapy for Parkinson’s disease premotor symptoms
Parkinson’s disease (PD) is a neurodegenerative disorder with motor deficits due to nigrostriatal dopamine depletion and with the non-motor/premotor symptoms (NMS) such as anxiety, cognitive dysfunction, depre...
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Article
Open AccessReference intervals of gestational sac, yolk sac, embryonic length, embryonic heart rate at 6–10 weeks after in vitro fertilization-embryo transfer
Accurately determining the normal range of early pregnancy markers can help to predict adverse pregnancy outcomes. The variance in ovulation days leads to uncertain accuracy of reference intervals for natural ...
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Article
Open AccessTesting optimally weighted combination of variants for hypertension
Testing rare variants directly is possible with next-generation sequencing technology. In this article, we propose a sliding-window-based optimal-weighted approach to test for the effects of both rare and comm...
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Open AccessDetecting association of rare and common variants by testing an optimally weighted combination of variants with longitudinal data
Increasing evidence shows that complex diseases are caused by both common and rare variants. Recently, several statistical methods for detecting associations of rare variants have been developed, including the...
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Open AccessDetection of rare variant effects in association studies: extreme values, iterative regression, and a hybrid approach
We develop statistical methods for detecting rare variants that are associated with quantitative traits. We propose two strategies and their combination for this purpose: the iterative regression strategy and ...
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Article
Aspirin inhibits ErbB2 to induce apoptosis in cervical cancer cells
The use of aspirin is associated with a lower risk of many cancer types. However, there are few reports about cervical cancer. The proto-oncogene ErbB2 is overexpressed in cervical cancer, and considered as a ...
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Open AccessDetecting susceptibility genes for rheumatoid arthritis based on a novel sliding-window approach
With the recent rapid improvements in high-throughout genoty** techniques, researchers are facing a very challenging task of large-scale genetic association analysis, especially at the whole-genome level, wi...
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Open AccessA combinatorial approach for detecting gene-gene interaction using multiple traits of Genetic Analysis Workshop 16 rheumatoid arthritis data
Rheumatoid arthritis is inherited in a complex manner. So far several single susceptibility genes, such as PTPN22, STAT4, and TRAF1-C5, have been identified. However, it is presumed that some genes may interact t...
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Open AccessGenome-wide association tests by using block information in family data
By applying an association test to analyze the data sets from Genetic Analysis Workshop 15 Problem 3, we compare power using different haplotype-block information. The results from using both of the two differ...
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Article
Open AccessGenome-wide association tests by two-stage approaches with unified analysis of families and unrelated individuals
Multiple testing is a problem in genome-wide or region-wide association studies. In this report, we consider a study design given by the Genetic Analysis Workshop 15 (GAW15) Problem 3 – nuclear families (paren...
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Open AccessA method dealing with a large number of correlated traits in a linkage genome scan
We propose a method to perform linkage genome scans for many correlated traits in the Genetic Analysis Workshop 15 (GAW15) data. The proposed method has two steps: first, we use a clustering method to find the...
