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Article

ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination

Ariadne homolog 2 (ARIH2) is a key member of the RING-between-RING (RBR) E3 ligase family, which is characterized by an RBR domain involved in the polyubiquitination process. However, the molecular mechanism a...

Shengjun Geng, Wen Peng, Xue Wang, **aosong Hu, Hanghua Liang… in Cell Death & Disease (2022)