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    Article

    Expression of NOX Family Genes and Their Clinical Significance in Colorectal Cancer

    The NADPH oxidase (NOX) family is overexpressed in many cancers and is associated with cancer cell proliferation and metastasis; however, little is known about the role of the NOX family in colorectal cancer (...

    Sang Yeon Cho, Ju Seok Kim, Hyuk Soo Eun, Sun Hyung Kang in Digestive Diseases and Sciences (2018)

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    Article

    Clinical Significance of the Thioredoxin System and Thioredoxin-Domain-Containing Protein Family in Hepatocellular Carcinoma

    Oxidative stress occurs due to the excessive generation of cellular reactive oxygen species and antioxidant system dysfunction. The thioredoxin (TXN) system and TXN-domain-containing protein (TXNDC) family for...

    Sang Yeon Cho, Sungha Kim, Mi-Ju Son, Woo Sun Rou in Digestive Diseases and Sciences (2019)

  3. Article

    Open Access

    Clinical significance of atypical protein kinase C (PKCι and PKCζ) and its relationship with yes-associated protein in lung adenocarcinoma

    Protein kinase C iota (PKCι) and protein kinase C zeta (PKCζ) are two atypical protein kinase (aPKC) enzymes that contribute to cell proliferation and cancer development. The Hippo/YAP pathway is commonly disr...

    Kyung-Hee Kim, Chaeuk Chung, **-Man Kim, Dahye Lee, Sang Yeon Cho in BMC Cancer (2019)

  4. Article

    Open Access

    Dual oxidase 1 and NADPH oxidase 2 exert favorable effects in cervical cancer patients by activating immune response

    Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-derived reactive oxygen species (ROS) not only can promote cancer progression, but also they have recently emerged as mediators of the mucosal immune...

    Sang Yeon Cho, Sungha Kim, Mi-Ju Son, Gwanghun Kim, Parul Singh, Ha Neul Kim in BMC Cancer (2019)

  5. Article

    Open Access

    Suppression of Mig-6 overcomes the acquired EGFR-TKI resistance of lung adenocarcinoma

    The resistance of lung cancer to epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) is one of the unconquered frontiers in chemotherapy. Mitogen-inducible gene 6 (Mig-6) is known to inhibit ...

    Da Hyun Kang, Sung Soo Jung, Min-Kyung Yeo, Da Hye Lee, Geon Yoo in BMC Cancer (2020)