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  1. Article

    Open Access

    Treatment of human hepatocellular carcinoma by the oncolytic herpes simplex virus G47delta

    Oncolytic herpes simplex virus (HSV) can replicate in and kill cancer cells while sparing the adjacent normal tissue. Hepatocellular carcinoma (HCC) is amongst the most common and lethal cancers, especially in...

    Jiani Wang, Lihua Xu, Weigen Zeng, Pan Hu, Musheng Zeng in Cancer Cell International (2014)

  2. No Access

    Article

    Attenuated multi–mutated herpes simplex virus–1 for the treatment of malignant gliomas

    We have created a double mutant of the herpes simplex virus (HSV) type 1 (termed G207) with favourable properties for treating human malignant brain tumours: replication–competence in glioblastoma cells (and o...

    Toshihiro Mineta, Samuel D. Rabkin, Takahito Yazaki, William D. Hunter in Nature Medicine (1995)