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Article

Curcumin derivative C817 inhibits proliferation of imatinib-resistant chronic myeloid leukemia cells with wild-type or mutant Bcr-Abl in vitro

To find new kinase inhibitors that overcome the imatinib resistance in treatment of chronic myeloid leukemia (CML), we synthesized C817, a novel derivative of curcumin, and tested its activities against wild-t...

Li-xian Wu, Ying Wu, Rui-jia Chen, Yang Liu, Li-sen Huang… in Acta Pharmacologica Sinica (2014)