-
Article
Open AccessPredictive significance of glycolysis-associated lncRNA profiles in colorectal cancer progression
The Warburg effect is a hallmark characteristic of colorectal cancer (CRC). Despite extensive research, the role of long non-coding RNAs (lncRNAs) in influencing the Warburg effect remains incompletely underst...
-
Article
Open AccessAdaptive key partitioning in distributed stream processing
In stream processing systems, Key Grou** is a commonly employed partitioning scheme for distributing input tuples among parallel instances of stateful operators. With key grou**, tuples shared public keys ...
-
Article
Open AccessDeciphering the contributing motifs of reconstructed cobalt (II) sulfides catalysts in Li-CO2 batteries
Develo** highly efficient catalysts is significant for Li-CO2 batteries. However, understanding the exact structure of catalysts during battery operation remains a challenge, which hampers knowledge-driven opti...
-
Article
Open AccessImpairments of GABAergic transmission in hippocampus mediate increased susceptibility of epilepsy in the early stage of Alzheimer’s disease
Patients with Alzheimer’s disease (AD) are often co-morbid with unprovoked seizures, making clinical diagnosis and management difficult. Although it has an important role in both AD and epilepsy, abnormal γ-am...
-
Article
Open AccessAn extended substrate screening strategy enabling a low lattice mismatch for highly reversible zinc anodes
Aqueous zinc batteries possess intrinsic safety and cost-effectiveness, but dendrite growth and side reactions of zinc anodes hinder their practical application. Here, we propose the extended substrate screeni...
-
Article
Open Accessc-Jun as a one-way valve at the naive to primed interface
c-Jun is a proto-oncogene functioning as a transcription factor to activate gene expression under many physiological and pathological conditions, particularly in somatic cells. However, its role in early embry...
-
Article
Open AccessLeveraging a cuproptosis-based signature to predict the prognosis and drug sensitivity of cutaneous melanoma
Immunotherapy is a vital treatment for patients with cutaneous melanoma (CM), but effective predictors to guide clinical immunotherapy are lacking. Cuproptosis is a newly discovered mode of cell death related ...
-
Article
Open AccessJCBIE: a joint continual learning neural network for biomedical information extraction
Extracting knowledge from heterogeneous data sources is fundamental for the construction of structured biomedical knowledge graphs (BKGs), where entities and relations are represented as nodes and edges in the...
-
Article
Open AccessNeuronal Death Mechanisms and Therapeutic Strategy in Ischemic Stroke
Ischemic stroke caused by intracranial vascular occlusion has become increasingly prevalent with considerable mortality and disability, which gravely burdens the global economy. Current relatively effective cl...
-
Article
Open AccessIdentification and genetic diversity analysis of Rickettsia in Dermacentor nuttalli within inner Mongolia, China
The genus Rickettsia contains the lineages spotted fever group (SFG), typhus group (TG), and transitional group (TRG). The spotted fever group Rickettsia (SFGR) is transmitted by ticks. The tick species Dermacent...
-
Article
Open AccessIdentification of useful genes from multiple microarrays for ulcerative colitis diagnosis based on machine learning methods
Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease with an increasing incidence and prevalence worldwide. The diagnosis for UC mainly relies on clinical symptoms and laboratory examinati...
-
Article
Open AccessVideo-assisted subtotal parietal pleurectomy: an effective procedure for recurrent refractory pneumothorax
Refractory pneumothorax combined with diffuse emphysematous changes is an intractable problem requiring surgical treatment. Traditional bullectomy may result in long-term air leakage and has a risk of early re...
-
Article
Open AccessvChecker: an application-level demand-based co-scheduler for improving the performance of parallel jobs in Xen
Big data analysis requires the speedup of parallel computing. However, in the virtualized systems, the power of parallel computing is not fully exploited due to the limit of current VMM schedulers. Xen, one of...
-
Article
Open AccessDNAJB8 in small extracellular vesicles promotes Oxaliplatin resistance through TP53/MDR1 pathway in colon cancer
Chemotherapy is one of the most frequently used therapies for the treatment of colon cancer (COAD). However, Oxaliplatin (L-OHP) resistance is a major obstacle to the effective treatment of COAD. Here, we inve...
-
Article
Open AccessCircNPHP4 in monocyte-derived small extracellular vesicles controls heterogeneous adhesion in coronary heart atherosclerotic disease
Small extracellular vesicles (sEVs)-derived circular RNAs (circRNAs) could regulate gene expression in recipient cells, and dysregulation of sEVs-derived circRNAs has been implicated in several diseases. Howev...
-
Article
Open AccessPreoperatively elevated RDW-SD and RDW-CV predict favorable survival in intrahepatic cholangiocarcinoma patients after curative resection
Recent studies suggest red blood cell distribution width (RDW) was a prognostic factor in various types of cancer patients, although the results are controversial. The objective of this study was to investigat...
-
Article
Fire lines as fault lines: increased trade barriers during the COVID-19 pandemic further shatter the global food system
In this opinion piece, we highlight that trade barriers established during COVID-19 as “fire lines” to prevent cross-border transmission of the pandemic could become “fault lines” that demolish the global food...
-
Article
Open AccessWind Erosion Climate Change in Northern China During 1981–2016
Wind erosion is largely controlled by climate conditions. In this study, we examined the influences of changes in wind speed, soil wetness, snow cover, and vegetation cover related to climate change on wind er...
-
Article
Open AccessGenoty** of 30 kinds of cutaneous human papillomaviruses by a multiplex microfluidic loop-mediated isothermal amplification and visual detection method
Human papillomaviruses (HPVs), a group of non-enveloped small viruses with double-stranded circular DNA which lead to multiple skin diseases such as benign warts, are commonly seen in clinics. The current HPV ...
-
Article
Open AccessThe lncRNA RP11-142A22.4 promotes adipogenesis by sponging miR-587 to modulate Wnt5β expression
Emerging evidence suggests that long noncoding RNAs (lncRNAs) play essential roles in the regulation of gene expression. However, the functional contributions of lncRNAs to adipogenesis remain largely unexplor...
