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Article
Open AccessA potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases
HsTX1 toxin, from the scorpion Heterometrus spinnifer, is a 34-residue, C-terminally amidated peptide cross-linked by four disulfide bridges. Here we describe new HsTX1 analogues with an Ala, Phe, Val or Abu subs...
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Article
Mechanisms of Periodic Acceleration Induced Endothelial Nitric Oxide Synthase (eNOS) Expression and Upregulation Using an In Vitro Human Aortic Endothelial Cell Model
Following severe injury in cases like ischemia reperfusion, recovery and tissue repair are compromised due to microvascular failure. Nitric oxide (NO) has been shown to have both vasodilatory and anti-inflamma...
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Article
Exploiting osmosis for blood cell sorting
Blood is a valuable tissue containing cellular populations rich in information regarding the immediate immune and inflammatory status of the body. Blood leukocytes or white blood cells (WBCs) provide an ideal ...
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Article
Open AccessLigand-induced nuclear translocation of S1P1 receptors mediates Cyr61 and CTGF transcription in endothelial cells
Sphingosine-1-phosphate (S1P) receptor subtype 1 (S1P1), a G-protein coupled receptor (GPCR), regulates many biological activities of endothelial cells (ECs). In this report, we show that S1P1 receptors are prese...