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within Article Remove this filter Robert L. Wilensky Remove this filter Biomedicine, general Remove this filter

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  1. No Access

    Article

    Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development

    Although increased levels of lipoprotein-associated phospholipase A2 (Lp-PLA2) have been associated with cardiac disease, whether this enzyme has a causal role in the development of atherosclerosis has not bee...

    Robert L Wilensky, Yi Shi, Emile R Mohler III, Damir Hamamdzic… in Nature Medicine (2008)

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    Article

    Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes

    We performed a genome-wide association scan to search for sequence variants conferring risk of prostate cancer using 1,501 Icelandic men with prostate cancer and 11,290 controls. Follow-up studies involving th...

    Julius Gudmundsson, Patrick Sulem, Valgerdur Steinthorsdottir… in Nature Genetics (2007)

  3. No Access

    Article

    A variant in CDKAL1 influences insulin response and risk of type 2 diabetes

    We conducted a genome-wide association study for type 2 diabetes (T2D) in Icelandic cases and controls, and we found that a previously described variant in the transcription factor 7-like 2 gene (TCF7L2) gene con...

    Valgerdur Steinthorsdottir, Gudmar Thorleifsson, Inga Reynisdottir… in Nature Genetics (2007)

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    Article

    Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

    We recently described an association between risk of type 2diabetes and variants in the transcription factor 7-like 2 gene (TCF7L2; formerly TCF4), with a population attributable risk (PAR) of 17%–28% in three po...

    Agnar Helgason, Snæbjörn Pálsson, Gudmar Thorleifsson, Struan F A Grant… in Nature Genetics (2007)

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    Article

    Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

    We have previously reported suggestive linkage of type 2 diabetes mellitus to chromosome 10q1. We genotyped 228 microsatellite markers in Icelandic individuals with type 2 diabetes and controls throughout a 10.5-...

    Struan F A Grant, Gudmar Thorleifsson, Inga Reynisdottir… in Nature Genetics (2006)

  6. No Access

    Article

    Gene delivery from a DNA controlled-release stent in porcine coronary arteries

    Expandable intra-arterial stents are widely used for treating coronary disease. We hypothesized that local gene delivery could be achieved with the controlled release of DNA from a polymer coating on an expand...

    Bruce D. Klugherz, Peter L. Jones, **umin Cui, Weiliam Chen… in Nature Biotechnology (2000)